Cited 15 times in
Optimal bolus dose of alfentanil for successful tracheal intubation during sevoflurane induction with and without nitrous oxide in children.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김지영 | - |
dc.date.accessioned | 2015-04-23T16:42:20Z | - |
dc.date.available | 2015-04-23T16:42:20Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0007-0912 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101070 | - |
dc.description.abstract | BACKGROUND: The goals of this study were to determine the effective bolus dose of alfentanil required for successful tracheal intubation during inhalation induction using sevoflurane 5% without neuromuscular block in children, and whether nitrous oxide reduces these doses. METHODS: Fifty paediatric patients, aged 3-10 yr, were randomly assigned to one of the two groups. Subjects received either sevoflurane 5% in oxygen 100% (O(2) group, n=25) or sevoflurane 5% in oxygen 40% and nitrous oxide 60% (N(2)O group, n=25) through a face mask. One minute after inhalation induction, a predetermined dose of alfentanil was injected over 15 s. The alfentanil dose was determined using Dixon's up-and-down method, starting from alfentanil 14 microg kg(-1). The trachea was intubated 3 min after inducing anaesthesia. RESULTS: The ED(50) [95% confidence interval (CI)] of alfentanil for successful tracheal intubation was 11.5 (9.9-13.1) and 8.6 (7.4-9.8) microg kg(-1) in the O(2) and N(2)O groups, respectively. The ED(50) of the N(2)O group was significantly lower than that of the O(2) group (P=0.0146)(.) From isotonic regression, 50% effective dose (ED(50)) (95% CI) of alfentanil in the O(2) and N(2)O groups was 11.4 (9.9-13.0) and 6.5 (5.0-8.1) microg kg(-1), respectively. CONCLUSIONS: The effective bolus dose of alfentanil for successful tracheal intubation was 11.5 microg kg(-1) in 50% of children during inhalation induction using sevoflurane 5% without neuromuscular blocking agent. Addition of nitrous oxide 60% in oxygen reduced the effective alfentanil dose by 25%. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 628~632 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF ANAESTHESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alfentanil/administration & dosage* | - |
dc.subject.MESH | Analgesics, Opioid/administration & dosage* | - |
dc.subject.MESH | Anesthetics, Combined | - |
dc.subject.MESH | Anesthetics, Inhalation | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemodynamics/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intubation, Intratracheal/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methyl Ethers* | - |
dc.subject.MESH | Nitrous Oxide* | - |
dc.title | Optimal bolus dose of alfentanil for successful tracheal intubation during sevoflurane induction with and without nitrous oxide in children. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | H. J. Kwak | - |
dc.contributor.googleauthor | J. Y.Kim | - |
dc.contributor.googleauthor | S. K.Min | - |
dc.contributor.googleauthor | J. S.Kim | - |
dc.contributor.googleauthor | J. Y. Kim | - |
dc.identifier.doi | 10.1093/bja/aeq055 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00977 | - |
dc.relation.journalcode | J00405 | - |
dc.identifier.eissn | 1471-6771 | - |
dc.identifier.pmid | 20335182 | - |
dc.subject.keyword | anaesthesia | - |
dc.subject.keyword | paediatricanaesthetics gases | - |
dc.subject.keyword | nitrous oxideanaesthetics volatile | - |
dc.subject.keyword | sevofluraneanalgesics opioid | - |
dc.subject.keyword | alfentanilequipment | - |
dc.subject.keyword | tubes tracheal | - |
dc.contributor.alternativeName | Kim, Ji Young | - |
dc.contributor.affiliatedAuthor | Kim, Ji Young | - |
dc.citation.volume | 104 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 628 | - |
dc.citation.endPage | 632 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF ANAESTHESIA, Vol.104(5) : 628-632, 2010 | - |
dc.identifier.rimsid | 50812 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.