Cited 24 times in
Detection of t(3;5) and NPM1/MLF1 rearrangement in an elderly patient with acute myeloid leukemia: clinical and laboratory study with review of the literature
DC Field | Value | Language |
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dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-04-23T16:40:15Z | - |
dc.date.available | 2015-04-23T16:40:15Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0165-4608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101006 | - |
dc.description.abstract | We present a novel case of acute myeloid leukemia with an NPM1/MLF1 rearrangement in a 78-year-old Korean woman. The bone marrow chromosome study showed a complex karyotype: 46,XX,t(2;13) (q13;q32),der(3)t(3;5)(q25.1;q34),der(5)del(5)(?q31q34)t(3;5),inv(9)(p11q13)c,del(20)(q11.2)[13]/49,idem,+5,+8,+der(13)t(2;13)[7]. Multiplex gene rearrangement testing, cloning, and sequencing analyses revealed an NPM1/MLF1 fusion rearrangement between exon 6 of NPM1 (ENSG00000181163) and exon 2 of MLF1 (ENSG00000178053). Although t(3;5)(q25.1;q34) or the NPM1/MLF1 rearrangement has been reported mostly as a sole karyotypic abnormality in younger patients, it should also be considered in elderly patients with complex chromosomal abnormalities in acute myeloid leukemia or myelodysplastic syndrome. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 101~109 | - |
dc.relation.isPartOf | CANCER GENETICS AND CYTOGENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Chromosomes, Human, Pair 3/genetics* | - |
dc.subject.MESH | Chromosomes, Human, Pair 5/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Rearrangement* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Karyotyping | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/genetics* | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/pathology | - |
dc.subject.MESH | Nuclear Proteins/genetics* | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Proteins/genetics* | - |
dc.subject.MESH | Translocation, Genetic/genetics* | - |
dc.title | Detection of t(3;5) and NPM1/MLF1 rearrangement in an elderly patient with acute myeloid leukemia: clinical and laboratory study with review of the literature | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Gayoung Lim | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.contributor.googleauthor | Min Jin Kim | - |
dc.contributor.googleauthor | So Young Kim | - |
dc.contributor.googleauthor | Hee Joo Lee | - |
dc.contributor.googleauthor | Jin-Tae Suh | - |
dc.contributor.googleauthor | Hwi-Joong Yoon | - |
dc.contributor.googleauthor | Juhie Lee | - |
dc.contributor.googleauthor | Sanggyu Lee | - |
dc.contributor.googleauthor | Woo-In Lee | - |
dc.contributor.googleauthor | Tae Sung Park | - |
dc.identifier.doi | 10.1016/j.cancergencyto.2010.02.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J00443 | - |
dc.identifier.eissn | 1873-4456 | - |
dc.identifier.pmid | 20471513 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0165460810000634 | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.citation.volume | 199 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 109 | - |
dc.identifier.bibliographicCitation | CANCER GENETICS AND CYTOGENETICS , Vol.199(2) : 101-109, 2010 | - |
dc.identifier.rimsid | 54506 | - |
dc.type.rims | ART | - |
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