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Effects of propofol on beta-adrenoceptor-mediated signal transduction in cardiac muscle; role of Camp

DC Field Value Language
dc.contributor.author박윤곤-
dc.contributor.author장철호-
dc.date.accessioned2015-04-23T16:37:51Z-
dc.date.available2015-04-23T16:37:51Z-
dc.date.issued2010-
dc.identifier.issn2005-6419-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100934-
dc.description.abstractBACKGROUND: Propofol may decrease myocardial contractility via actions on the beta-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via beta-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate). METHODS: The effects of propofol on beta-adrenoceptor mediated cascades were measured with cAMP concentrations, which were stimulated by agonists (l-isoproterenol, GTPgammaS, and forskolin) of each step of beta-adrenoceptor-mediated cascades. RESULTS: While the production of cAMP stimulated by isoproterenol, GTPgammaS, or forskolin are increased (P < 0.05), application of each concentration of propofol (0.1, 1, 10, 100 microM) did not alter the levels of cAMP. CONCLUSIONS: Considering that propofol did not alter the tissue cAMP levels when stimulated by isoproterenol, GTPgammaS, and forskolin, propofol appears to have no effect on the beta-adrenoceptor signaling pathway in guinea pig ventricular myocardi-
dc.description.statementOfResponsibilityopen-
dc.format.extent374~377-
dc.relation.isPartOfKOREAN JOURNAL OF ANESTHESIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of propofol on beta-adrenoceptor-mediated signal transduction in cardiac muscle; role of Camp-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorChul Ho Chang-
dc.contributor.googleauthorGo Un Roh-
dc.contributor.googleauthorWyun Kon Park-
dc.identifier.doi10.4097/kjae.2010.58.4.374-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01593-
dc.contributor.localIdA03485-
dc.relation.journalcodeJ01963-
dc.identifier.eissn2005-7563-
dc.identifier.pmid20508795-
dc.subject.keywordG-protein-
dc.subject.keywordPropofo l-
dc.subject.keywordcAMP-
dc.subject.keywordβ-adrenoceptor-
dc.contributor.alternativeNamePark, Wyun Kon-
dc.contributor.alternativeNameChang, Chul Ho-
dc.contributor.affiliatedAuthorPark, Wyun Kon-
dc.contributor.affiliatedAuthorChang, Chul Ho-
dc.citation.volume58-
dc.citation.number4-
dc.citation.startPage374-
dc.citation.endPage377-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF ANESTHESIOLOGY, Vol.58(4) : 374-377, 2010-
dc.identifier.rimsid54065-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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