Cited 1 times in
Effects of propofol on beta-adrenoceptor-mediated signal transduction in cardiac muscle; role of Camp
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박윤곤 | - |
dc.contributor.author | 장철호 | - |
dc.date.accessioned | 2015-04-23T16:37:51Z | - |
dc.date.available | 2015-04-23T16:37:51Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100934 | - |
dc.description.abstract | BACKGROUND: Propofol may decrease myocardial contractility via actions on the beta-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via beta-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate). METHODS: The effects of propofol on beta-adrenoceptor mediated cascades were measured with cAMP concentrations, which were stimulated by agonists (l-isoproterenol, GTPgammaS, and forskolin) of each step of beta-adrenoceptor-mediated cascades. RESULTS: While the production of cAMP stimulated by isoproterenol, GTPgammaS, or forskolin are increased (P < 0.05), application of each concentration of propofol (0.1, 1, 10, 100 microM) did not alter the levels of cAMP. CONCLUSIONS: Considering that propofol did not alter the tissue cAMP levels when stimulated by isoproterenol, GTPgammaS, and forskolin, propofol appears to have no effect on the beta-adrenoceptor signaling pathway in guinea pig ventricular myocardi | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 374~377 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF ANESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of propofol on beta-adrenoceptor-mediated signal transduction in cardiac muscle; role of Camp | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Chul Ho Chang | - |
dc.contributor.googleauthor | Go Un Roh | - |
dc.contributor.googleauthor | Wyun Kon Park | - |
dc.identifier.doi | 10.4097/kjae.2010.58.4.374 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01593 | - |
dc.contributor.localId | A03485 | - |
dc.relation.journalcode | J01963 | - |
dc.identifier.eissn | 2005-7563 | - |
dc.identifier.pmid | 20508795 | - |
dc.subject.keyword | G-protein | - |
dc.subject.keyword | Propofo l | - |
dc.subject.keyword | cAMP | - |
dc.subject.keyword | β-adrenoceptor | - |
dc.contributor.alternativeName | Park, Wyun Kon | - |
dc.contributor.alternativeName | Chang, Chul Ho | - |
dc.contributor.affiliatedAuthor | Park, Wyun Kon | - |
dc.contributor.affiliatedAuthor | Chang, Chul Ho | - |
dc.citation.volume | 58 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 374 | - |
dc.citation.endPage | 377 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.58(4) : 374-377, 2010 | - |
dc.identifier.rimsid | 54065 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.