2 271

Cited 16 times in

Adsorption of mesenchymal stem cells and cortical neural stem cells on carbon nanotube/polycarbonate urethane

Authors
 Yoonmi Nho  ;  Jong Youl Kim  ;  Dongwoo Khang  ;  Thomas J Webster  ;  Jong Eun Lee 
Citation
 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Vol.5(3) : 409-417, 2010 
Journal Title
 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 
ISSN
 1549-9634 
Issue Date
2010
MeSH
Adsorption ; Animals ; Cell Adhesion* ; Cell Survival ; Cells, Cultured ; Humans ; Mesenchymal Stromal Cells/cytology* ; Mice ; Nanotubes, Carbon/chemistry* ; Neurogenesis ; Neurons/cytology* ; Polycarboxylate Cement/chemistry ; Urethane/chemistry
Keywords
carbon nanotube ; cell adsorption ; differentiation ; neural stem cell ; polycarbonate urethane
Abstract
BACKGROUND & AIM: Carbon nanotubes (CNTs) are a promising material for implantation due to the fact that CNTs are conductive and have nanostructured dimensions that mimic the 3D structure of proteins found in extracellular matrices. We have investigated whether the CNTs interact with various types of stem cells and either selectively enhance survival of stem cells or not. MATERIALS & METHODS: CNTs used in the experiments are aligned with polycarbonate urethane. Experiments were carried out using mesenchymal stem cells (MSCs) and cortical derived neurospheres. Immunocytochemistry and scanning electron microscopic analysis were performed for determining the favorable surface material (either CNT or polycarbonate urethane array) for cell survival. RESULTS: It was demonstrated that the MSCs and the neurosphere of cortex-derived neural stem cells (NSCs) grew on the CNT array and both MSCs and NSCs interacted with the aligned CNTs. The results suggest that CNTs assist in the proliferation of MSCs and aid differentiation of cortex-derived NSCs. CONCLUSION: CNTs may be a novel biocompatible nanophase material with the potential for aiding neuron differentiation.
Full Text
http://www.futuremedicine.com/doi/abs/10.2217/nnm.10.16
DOI
10.2217/nnm.10.16
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youl(김종열) ORCID logo https://orcid.org/0000-0002-8340-2894
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100925
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links