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CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells

DC FieldValueLanguage
dc.contributor.author강숙희-
dc.contributor.author고명청-
dc.contributor.author윤주헌-
dc.contributor.author조남훈-
dc.contributor.author최윤표-
dc.date.accessioned2015-04-23T16:36:47Z-
dc.date.available2015-04-23T16:36:47Z-
dc.date.issued2010-
dc.identifier.issn0950-9232-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100901-
dc.description.abstractCancer stem cells (CSCs) have been identified in solid tumors and cancer cell lines. In this study, we isolated a series of cancer cell clones, which were heterogeneous in growth rate, cell cycle distribution and expression profile of genes and proteins, from ovarian tumor specimens of a patient and identified a sub-population enriched for ovarian CSCs defined by CD24 phenotype. Experiments in vitro demonstrated CD24(+) sub-population possessed stem cell-like characteristics of remaining quiescence and more chemoresistant compared with CD24(-) fraction, as well as a specific capacity for self-renewal and differentiation. In addition, injection of 5 x 10(3) CD24(+) cells was able to form tumor xenografts in nude mice, whereas equal number of CD24(-) cells remained nontumorigenic. We also found that CD24(+) cells expressed higher mRNA levels of some 'stemness' genes, including Nestin, beta-catenin, Bmi-1, Oct4, Oct3/4, Notch1 and Notch4 which were involved in modulating many functions of stem cells, and lower E-cadherin mRNA level than CD24(-) cells. Altogether, these observations suggest human ovarian tumor cells are organized as a hierarchy and CD24 demarcates an ovarian cancer-initiating cell population. These findings will have important clinical applications for developing effective therapeutic strategies to treat ovarian cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2672~2680-
dc.relation.isPartOfOncogene-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAC133 Antigen-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, CD/analysis-
dc.subject.MESHCD24 Antigen/analysis*-
dc.subject.MESHFemale-
dc.subject.MESHGlycoproteins/analysis-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHNeoplastic Stem Cells/pathology*-
dc.subject.MESHOvarian Neoplasms/chemistry-
dc.subject.MESHOvarian Neoplasms/pathology*-
dc.subject.MESHPeptides/analysis-
dc.subject.MESHProto-Oncogene Proteins c-kit/analysis-
dc.titleCD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorM-Q Gao-
dc.contributor.googleauthorY-P Choi-
dc.contributor.googleauthorS Kang-
dc.contributor.googleauthorJ H Youn-
dc.contributor.googleauthorN-H Cho-
dc.identifier.doi10.1038/onc.2010.35-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00044-
dc.contributor.localIdA00116-
dc.contributor.localIdA02604-
dc.contributor.localIdA03812-
dc.contributor.localIdA04143-
dc.relation.journalcodeJ02413-
dc.identifier.pmid20190812-
dc.identifier.urlhttp://www.nature.com/onc/journal/v29/n18/full/onc201035a.html-
dc.subject.keywordovarian cancer-
dc.subject.keywordcancer stem cell-
dc.subject.keywordtumorigenicity-
dc.contributor.alternativeNameKang, Suki-
dc.contributor.alternativeNameGao, Ming Qing-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.alternativeNameChoi, Yoon Pyo-
dc.contributor.affiliatedAuthorKang, Suki-
dc.contributor.affiliatedAuthorGao, Ming Qing-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.contributor.affiliatedAuthorChoi, Yoon Pyo-
dc.citation.volume29-
dc.citation.number18-
dc.citation.startPage2672-
dc.citation.endPage2680-
dc.identifier.bibliographicCitationOncogene, Vol.29(18) : 2672-2680, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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