Cited 22 times in
Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients
DC Field | Value | Language |
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dc.contributor.author | 김경래 | - |
dc.contributor.author | 남지선 | - |
dc.contributor.author | 박종숙 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 조민호 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-04-23T16:35:42Z | - |
dc.date.available | 2015-04-23T16:35:42Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0940-5429 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100868 | - |
dc.description.abstract | The inflammatory marker, C-reactive protein (CRP) is associated with long-term cardiovascular events. The aim of the study was to investigate the factors contributing to serum CRP, assess the relationship between CRP level and the parameters of visceral obesity, and examine the association between leptin and CRP level in type 2 diabetic patients. 150 patients with type 2 diabetes were enrolled. These patients were recently diagnosed (< or =3 years) with type 2 diabetes and were drug naive or taking sulfonylureas only. BMI, WC, and serum concentration of CRP, glycosylated hemoglobin (HbA1c), glucose, lipids, plasminogen activator-1 (PAI-1) and leptin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). We measured the carotid intima-media thickness (IMT). Fat mass assessed by dual-energy X-ray absorptionmetry and abdominal fat distribution was determined by CT scan. Serum concentration of CRP was significantly correlated with BMI (gamma = 0.257, P < 0.01), WC (gamma = 0.293, P < 0.01), fat mass (gamma = 0.213, P < 0.01), total adipose tissue (gamma = 0.263, P < 0.01), visceral adipose tissue (gamma = 0.296, P < 0.01), insulin (gamma = 0.189, P = 0.047), PAI-1 (gamma = 0.206, P < 0.01), leptin (gamma = 0.322, P < 0.01), mean IMT (gamma = 0.132, P = 0.042), and HOMA-IR (gamma = 0.172, P = 0.045). After adjustment for age and gender, multiple regression analysis showed that serum CRP was significantly associated with leptin (beta = 0.326, P = 0.01) and visceral adipose tissue (beta = 0.265, P = 0.035). In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue, and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 113~118 | - |
dc.relation.isPartOf | ACTA DIABETOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorptiometry, Photon | - |
dc.subject.MESH | Adiposity | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Glucose/analysis | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | C-Reactive Protein/metabolism* | - |
dc.subject.MESH | Carotid Arteries/diagnostic imaging | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycated Hemoglobin A/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intra-Abdominal Fat/anatomy & histology | - |
dc.subject.MESH | Intra-Abdominal Fat/metabolism* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Leptin/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Plasminogen Activator Inhibitor 1/blood | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Tunica Intima/diagnostic imaging | - |
dc.subject.MESH | Tunica Media/diagnostic imaging | - |
dc.subject.MESH | Ultrasonography | - |
dc.title | Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jong Suk Park | - |
dc.contributor.googleauthor | Min Ho Cho | - |
dc.contributor.googleauthor | Ji Sun Nam | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Sung Kil Lim | - |
dc.contributor.googleauthor | Kyung Rae Kim | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.identifier.doi | 10.1007/s00592-009-0125-4 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00294 | - |
dc.contributor.localId | A01268 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A03819 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A01660 | - |
dc.relation.journalcode | J00013 | - |
dc.identifier.eissn | 1432-5233 | - |
dc.identifier.pmid | 19415164 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00592-009-0125-4 | - |
dc.subject.keyword | CRP | - |
dc.subject.keyword | Leptin | - |
dc.subject.keyword | Visceral adipose tissue | - |
dc.subject.keyword | Type 2 diabetes | - |
dc.contributor.alternativeName | Kim, Kyung Rae | - |
dc.contributor.alternativeName | Nam, Ji Sun | - |
dc.contributor.alternativeName | Park, Jong Suk | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Cho, Min Ho | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Rae | - |
dc.contributor.affiliatedAuthor | Nam, Ji Sun | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Cho, Min Ho | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Park, Jong Suk | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 113 | - |
dc.citation.endPage | 118 | - |
dc.identifier.bibliographicCitation | ACTA DIABETOLOGICA, Vol.47(2) : 113-118, 2010 | - |
dc.identifier.rimsid | 55273 | - |
dc.type.rims | ART | - |
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