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Association of plasma retinol-binding protein 4, adiponectin, and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients

DC FieldValueLanguage
dc.contributor.author정남식-
dc.contributor.author최동훈-
dc.contributor.author하종원-
dc.contributor.author강석민-
dc.contributor.author고영국-
dc.contributor.author김중선-
dc.contributor.author박성하-
dc.contributor.author심지영-
dc.contributor.author장양수-
dc.date.accessioned2015-04-23T16:34:16Z-
dc.date.available2015-04-23T16:34:16Z-
dc.date.issued2010-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100825-
dc.description.abstractPURPOSE: The aim of this study was to determine whether retinol-binding protein 4 (RBP4), adiponectin and high molecular weight (HMW) adiponectin are associated with insulin resistance (IR) and metabolic parameters in non-diabetic hypertensive patients. Also, we sought to compare the predictive values of these adipocytokines for IR in non-diabetic hypertensive patients. MATERIALS AND METHODS: Analyses of RBP4, adiponectin, and HMW adiponectin were performed on 308 non-diabetic hypertensives (148 males, age 58 +/- 10 years, 189 non-metabolic syndrome and 119 metabolic syndrome). The homeostasis model assessment (HOMA) index for IR, lipid profiles, and anthropometric measurements were assessed. RESULTS: There was no significant difference in RBP4 levels according to the presence of metabolic syndrome, although adiponectin and HMW adiponectin were significantly lower in metabolic syndrome. Correlation analysis of log RBP4 with IR and metabolic indices revealed that there was no significant correlation of RBP4 with waist circumference (r = 0.056, p = 0.324), HDL cholesterol (r = 0.005, p = 0.934), ApoB/ApoAI ratio (r = 0.066, p = 0.270), and the HOMA index (r = 0.017, p = 0.756). However, adiponectin and HMW adiponectin showed significant correlations with the HOMA index (r = - 0.247, p < 0.001; r = - 0.296, p < 0.001) and metabolic parameters. With IR defined as HOMA index >or= 2.5, HMW adiponectin did not demonstrate a superior predictive value for IR compared to adiponectin (AUC = 0.680 vs. 0.648, p = 0.083). The predictive value of RBP4 for IR was minimal (AUC = 0.534). CONCLUSION: RBP4 was not associated with IR or metabolic indices and the predictive value for IR was minimal in hypertensives. HMW adiponectin didn't have a superior predictive value for IR compared to adiponectin. Therefore, we can suggest that RBP4 and HMW adiponectin don't have more additive information than adiponectin in non-diabetic hypertensives.-
dc.description.statementOfResponsibilityopen-
dc.format.extent375~384-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdiponectin/blood*-
dc.subject.MESHAged-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypertension/blood*-
dc.subject.MESHHypertension/physiopathology*-
dc.subject.MESHInsulin Resistance/physiology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRadioimmunoassay-
dc.subject.MESHRetinol-Binding Proteins, Plasma/metabolism*-
dc.subject.MESHRisk Factors-
dc.subject.MESHWaist Circumference/physiology-
dc.titleAssociation of plasma retinol-binding protein 4, adiponectin, and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorChi Young Shim-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorDong Jik Shin-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorJong-Won Ha-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorNamsik Chung-
dc.identifier.doi10.3349/ymj.2010.51.3.375-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03585-
dc.contributor.localIdA04053-
dc.contributor.localIdA04257-
dc.contributor.localIdA00037-
dc.contributor.localIdA00127-
dc.contributor.localIdA00961-
dc.contributor.localIdA01512-
dc.contributor.localIdA02213-
dc.contributor.localIdA03448-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid20376890-
dc.subject.keywordRetinol-binding proteins-
dc.subject.keywordadiponectin-
dc.subject.keywordhypertension-
dc.subject.keywordinsulin resistance-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHa, Jong Won-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHa, Jong Won-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.citation.volume51-
dc.citation.number3-
dc.citation.startPage375-
dc.citation.endPage384-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.51(3) : 375-384, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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