Cited 11 times in
Aldose reductase inhibitor ameliorates renal vascular endothelial growth factor expression in streptozotocin-induced diabetic rats.
DC Field | Value | Language |
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dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2015-04-23T16:33:10Z | - |
dc.date.available | 2015-04-23T16:33:10Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100792 | - |
dc.description.abstract | PURPOSE: The vascular endothelial growth factor (VEGF) expression of podocyte is one of the well-known major factors in development of diabetic nephropathy. In this study, we investigated the effects of aldose reductase inhibitor, fidarestat on diabetic nephropathy, and renal VEGF expression in a type 1 diabetic rat model. MATERIALS AND METHODS: Twenty four Sprague-Dawley male rats which were performed intraperitoneal injection of streptozotocin and normal six rats were divided into four groups including a normal control group, untreated diabetic control group, aldose reductase (AR) inhibitor (fidarestat, 16 mg kg(-1) day(-1)) treated diabetic group, and angiotensin receptor blocker (losartan, 20 mg kg(-1) day(-1)) treated diabetic group. We checked body weights and blood glucose levels monthly and measured urine albumin-creatinine ratio (ACR) at 8 and 32 weeks. We extracted the kidney to examine the renal morphology and VEGF expressions. RESULTS: The ACR decreased in fidarestat and losartan treated diabetic rat groups than in untreated diabetic group (24.79 +/- 11.12, 16.11 +/- 9.95, and 84.85 +/- 91.19, p < 0.05). The renal VEGF messenger RNA (mRNA) and protein expression were significantly decreased in the fidarestat and losartan treated diabetic rat groups than in the diabetic control group. CONCLUSION: We suggested that aldose reductase inhibitor may have preventive effect on diabetic nephropathy by reducing renal VEGF overexpression. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 385~391 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aldehyde Reductase/antagonists & inhibitors* | - |
dc.subject.MESH | Angiotensin Receptor Antagonists* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antihypertensive Agents/therapeutic use | - |
dc.subject.MESH | Diabetes Mellitus, Experimental/drug therapy* | - |
dc.subject.MESH | Diabetes Mellitus, Experimental/metabolism* | - |
dc.subject.MESH | Diabetic Nephropathies/prevention & control | - |
dc.subject.MESH | Imidazolidines/therapeutic use* | - |
dc.subject.MESH | Kidney/drug effects* | - |
dc.subject.MESH | Kidney/metabolism* | - |
dc.subject.MESH | Kidney/pathology | - |
dc.subject.MESH | Losartan/therapeutic use | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A | - |
dc.title | Aldose reductase inhibitor ameliorates renal vascular endothelial growth factor expression in streptozotocin-induced diabetic rats. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Joong Kyung Sung | - |
dc.contributor.googleauthor | Jang Hyun Koh | - |
dc.contributor.googleauthor | Mi Young Lee | - |
dc.contributor.googleauthor | Bo Hwan Kim | - |
dc.contributor.googleauthor | Soo Min Nam | - |
dc.contributor.googleauthor | Jae Hyun Kim | - |
dc.contributor.googleauthor | Jin Hee Yoo | - |
dc.contributor.googleauthor | So Hee Kim | - |
dc.contributor.googleauthor | Sun Won Hong | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | Ran Choi | - |
dc.contributor.googleauthor | Choon Hee Chung | - |
dc.identifier.doi | 10.3349/ymj.2010.51.3.385 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 20376891 | - |
dc.subject.keyword | Aldose reductase inhibitor | - |
dc.subject.keyword | vascular endothelial growth factor | - |
dc.subject.keyword | albumin creatinine ratio | - |
dc.subject.keyword | diabetic nephropathy | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.citation.volume | 51 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 385 | - |
dc.citation.endPage | 391 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.51(3) : 385-391, 2010 | - |
dc.identifier.rimsid | 37825 | - |
dc.type.rims | ART | - |
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