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Effects of Hyosine N-butyl bromide on the detection of polyps during colonoscopy

Authors
 JUNG MIN LEE  ;  JAE HEE CHEON  ;  JAE JUN PARK  ;  CHANG MO MOON  ;  EUN SOO KIM  ;  TAE IL KIM  ;  WON HO KIM 
Citation
 HEPATO-GASTROENTEROLOGY, Vol.57(97) : 90-94, 2010 
Journal Title
 HEPATO-GASTROENTEROLOGY 
ISSN
 0172-6390 
Issue Date
2010
MeSH
Aged ; Butylscopolammonium Bromide*/administration & dosage ; Colonic Polyps/pathology* ; Colonic Polyps/surgery* ; Colonoscopy/adverse effects ; Colonoscopy/methods* ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Male ; Middle Aged ; Parasympatholytics*/administration & dosage ; Prospective Studies ; Spasm/etiology ; Spasm/prevention & control*
Abstract
BACKGROUND/AIMS: Colonoscopy has a significant miss rate for colorectal polyp screening. The present study hypothesized that reduced colonic spasm with antispasmodic agents might yield a better visual field to result in enhanced polyp detection rate. METHODOLOGY: In a prospective, randomized, double-blind study design, muscle spasm was recorded during insertion and withdrawal during routine colonoscopy, and the number of polyps detected were compared between two groups of 58 patients characterized with either hyosine N-butyl bromide (Hyosine group) or placebo (Placebo group) injected at reaching the cecum. RESULTS: The number of patients with decrease in spasm score of 0, 1, and 2 between insertion and withdrawal were 5 (8.6%), 31 (53.4%), and 22 (37.9%) in the Hyosine group, and 10 (17.2%), 46 (79.3%), and 2 (3.4%) in the Placebo group, respectively (p < 0.001). In patients with spasm score > or = 3 during insertion, more polyps per patient were likely to be detected in the Hyoscine group than the Placebo group (1.21 +/- 2.23 vs. 0.41 +/- 0.91; p = 0.060). CONCLUSIONS: Our study suggests that hyosine might increase the detection rate of polyps in patients with moderate to marked degree of colonic spasm during colonoscope insertion. Further large scale studies are needed to validate our observations
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Eun Soo(김은수)
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Moon, Chang Mo(문창모)
Park, Jae Jun(박재준)
Lee, Jung Min(이중민)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100785
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