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Topographical distribution of cerebral cortical thinning in patients with mild Parkinson's disease without dementia.

Authors
 Chul Hyoung Lyoo  ;  Young Hoon Ryu  ;  Myung Sik Lee 
Citation
 MOVEMENT DISORDERS, Vol.25(4) : 496-499, 2010 
Journal Title
 MOVEMENT DISORDERS 
ISSN
 0885-3185 
Issue Date
2010
MeSH
Adult ; Age of Onset ; Aged ; Atrophy/epidemiology ; Atrophy/pathology ; Brain Mapping/methods* ; Cerebral Cortex/anatomy & histology* ; Cerebral Cortex/pathology* ; Dementia/diagnosis ; Dementia/epidemiology* ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease/epidemiology* ; Parkinson Disease/pathology*
Keywords
essential tremor ; cognition ; dementia ; minimental status ; functional disability ; epidemiology ; Alzhei-mer’s disease
Abstract
The pathology of Parkinson's disease (PD) is not confined to the brainstem regions, but spreads to involve the neocortical areas. Using surface-based cortical thickness analysis, we studied the topographical distribution of cortical thinning in nondemented patients with mild PD. The high-resolution magnetic resonance imaging (MRI) studies were performed in 48 patients with PD without dementia and 56 age-matched healthy controls. Using the Freesurfer software, surface-based analysis was done to find changes in cerebral cortical thickness in patients with PD. Compared to the controls, patients with PD showed significant cortical thinning in the temporal, inferior parietal, rostral frontal, and orbitofrontal cortical areas. Thinning of the cerebral cortex occurs even in nondemented patients with mild PD, and its topographical distribution was similar to that of the neocortical Lewy bodies. Further studies are needed to find pathological and clinical correlates of thinned cerebral cortex found in nondemented patients with mild PD
DOI
10.1002/mds.22975
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100774
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