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Fentanyl sparing effects of combined ketorolac and acetaminophen for outpatient inguinal hernia repair in children.

DC FieldValueLanguage
dc.contributor.author길혜금-
dc.contributor.author김원옥-
dc.contributor.author한상원-
dc.contributor.author홍정연-
dc.date.accessioned2015-04-23T16:32:23Z-
dc.date.available2015-04-23T16:32:23Z-
dc.date.issued2010-
dc.identifier.issn0022-5347-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100768-
dc.description.abstractPURPOSE: In this prospective, randomized, double-blinded study we sought to evaluate the efficacy and safety of combined use of intravenous ketorolac and acetaminophen in small children undergoing outpatient inguinal hernia repair. MATERIALS AND METHODS: We studied 55 children 1 to 5 years old who were undergoing elective repair of unilateral inguinal hernia. After induction of general anesthesia children in the experimental group (28 patients) received 1 mg/kg ketorolac and 20 mg/kg acetaminophen intravenously. In the control group (27 patients) the same volume of saline was administered. All patients received 1 microg/kg fentanyl intravenously before incision. We also evaluated the number of patients requiring postoperative rescue fentanyl, total fentanyl consumption, pain scores and side effects. RESULTS: Significantly fewer patients receiving ketorolac-acetaminophen received postoperative rescue fentanyl compared to controls (28.6% vs 81.5%). A significantly lower total dose of fentanyl was administered to patients receiving ketorolac-acetaminophen compared to controls (0.54 vs 1.37 microg/kg). Pain scores were significantly higher in the control group immediately postoperatively but eventually decreased. The incidences of sedation use (55.6% vs 25.0%) and vomiting (33.3% vs 10.7%) were significantly higher in controls. CONCLUSIONS: Preoperative intravenous coadministration of ketorolac and acetaminophen is a simple, safe and effective method for relieving postoperative pain, and demonstrates highly significant fentanyl sparing effects in small children after outpatient inguinal hernia repair-
dc.description.statementOfResponsibilityopen-
dc.format.extent1551~1555-
dc.relation.isPartOfJOURNAL OF UROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcetaminophen/administration & dosage*-
dc.subject.MESHAmbulatory Surgical Procedures-
dc.subject.MESHAnalgesics, Non-Narcotic/administration & dosage*-
dc.subject.MESHAnalgesics, Opioid/administration & dosage*-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/administration & dosage*-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHFentanyl/administration & dosage*-
dc.subject.MESHHernia, Inguinal/surgery*-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHInfusions, Intravenous-
dc.subject.MESHKetorolac/administration & dosage*-
dc.subject.MESHPain, Postoperative/prevention & control*-
dc.subject.MESHProspective Studies-
dc.titleFentanyl sparing effects of combined ketorolac and acetaminophen for outpatient inguinal hernia repair in children.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorJeong-Yeon Hong-
dc.contributor.googleauthorSang Won Han-
dc.contributor.googleauthorWon Oak Kim-
dc.contributor.googleauthorHae Keum Kil-
dc.identifier.doi10.1016/j.juro.2009.12.043-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00283-
dc.contributor.localIdA00766-
dc.contributor.localIdA04430-
dc.contributor.localIdA04285-
dc.relation.journalcodeJ01921-
dc.identifier.eissn1527-3792-
dc.identifier.pmid20172547-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0022534709032078-
dc.subject.keywordacetaminophen-
dc.subject.keywordanalgesia-
dc.subject.keywordketorolac-
dc.subject.keywordpain-
dc.subject.keywordpostoperative-
dc.subject.keywordpediatrics-
dc.contributor.alternativeNameKil, Hae Keum-
dc.contributor.alternativeNameKim, Won Oak-
dc.contributor.alternativeNameHan, Sang Won-
dc.contributor.alternativeNameHong, Jeong Yeon-
dc.contributor.affiliatedAuthorKil, Hae Keum-
dc.contributor.affiliatedAuthorKim, Won Oak-
dc.contributor.affiliatedAuthorHong, Jeong Yeon-
dc.contributor.affiliatedAuthorHan, Sang Won-
dc.citation.volume183-
dc.citation.number4-
dc.citation.startPage1551-
dc.citation.endPage1555-
dc.identifier.bibliographicCitationJOURNAL OF UROLOGY, Vol.183(4) : 1551-1555, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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