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Clinical Features and Outcomes of Idiopathic Pulmonary Alveolar Proteinosis in Korean Population

DC FieldValueLanguage
dc.contributor.author박무석-
dc.contributor.author변민광-
dc.date.accessioned2015-04-23T16:30:59Z-
dc.date.available2015-04-23T16:30:59Z-
dc.date.issued2010-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100725-
dc.description.abstractIdiopathic pulmonary alveolar proteinosis (PAP) is a rare disorder in which lipoproteinaceous material accumulates within alveoli. There were few reports on Asian populations with idiopathic PAP. We retrospectively reviewed 38 patients with idiopathic PAP in Korea. We assessed clinical features, therapeutic efficacy and outcomes of whole lung lavage in patients with idiopathic PAP. The mean age at diagnosis was 52 yr. Eighty six percent of patients were symptomatic at diagnosis. Dyspnea and cough were the most common symptoms. Crackles were the most common physical examination finding. On pulmonary function test, a mild restrictive ventilatory defect was common, with a predicted mean forced vital capacity (FVC) of 77% and forced expiratory volume in one second (FEV1) of 84.6%. Diffusing capacity was disproportionately reduced at 67.7%. Arterial blood gas analysis revealed hypoxemia with a decreased PaO2 of 69.0 mmHg and an increased D(A-a)O2 of 34.2 mmHg. After whole lung lavage, PaO2, D(A-a)O2 and DLCO were significantly improved, but FVC and total lung capacity (TLC) were not different. This is the first multicenter study to analyze 38 Korean patients with idiopathic PAP. The clinical features and pulmonary parameters of Korean patients with idiopathic PAP are consistent with reports in other published studies. Whole lung lavage appears to be the most effective form of treatment-
dc.description.statementOfResponsibilityopen-
dc.format.extent393~398-
dc.relation.isPartOfJournal of Korean Medical Science-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiopsy-
dc.subject.MESHBronchoalveolar Lavage-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPulmonary Alveolar Proteinosis/diagnosis-
dc.subject.MESHPulmonary Alveolar Proteinosis/pathology-
dc.subject.MESHPulmonary Alveolar Proteinosis/physiopathology*-
dc.subject.MESHPulmonary Alveolar Proteinosis/therapy*-
dc.subject.MESHRespiratory Function Tests-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.titleClinical Features and Outcomes of Idiopathic Pulmonary Alveolar Proteinosis in Korean Population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMin Kwang Byun-
dc.contributor.googleauthorDong Soon Kim-
dc.contributor.googleauthorYoung Whan Kim-
dc.contributor.googleauthorMan Pyo Chung-
dc.contributor.googleauthorJae Jeong Shim-
dc.contributor.googleauthorSeung Ick Cha-
dc.contributor.googleauthorSoo-Taek Uh-
dc.contributor.googleauthorChoon Sik Park-
dc.contributor.googleauthorSung Hwan Jeong-
dc.contributor.googleauthorYong Bum Park-
dc.contributor.googleauthorHong Lyeol Lee-
dc.contributor.googleauthorMoo Suk Park-
dc.identifier.doi10.3346/jkms.2010.25.3.393-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01457-
dc.contributor.localIdA01848-
dc.relation.journalcodeJ01517-
dc.identifier.pmid20191038-
dc.subject.keywordIrrigation-
dc.subject.keywordKoreans-
dc.subject.keywordPulmonary Alveolar Proteinosis-
dc.subject.keywordTreatment Outcome-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNameByun, Min Kwang-
dc.contributor.affiliatedAuthorPark, Moo Suk-
dc.contributor.affiliatedAuthorByun, Min Kwang-
dc.citation.volume25-
dc.citation.number3-
dc.citation.startPage393-
dc.citation.endPage398-
dc.identifier.bibliographicCitationJournal of Korean Medical Science, Vol.25(3) : 393-398, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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