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Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation

DC Field Value Language
dc.contributor.author최영득-
dc.date.accessioned2015-04-23T16:29:58Z-
dc.date.available2015-04-23T16:29:58Z-
dc.date.issued2010-
dc.identifier.issn1107-3756-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100694-
dc.description.abstractDecursin, a pyranocoumarin isolated from the Korean Angelica gigas root, has demonstrated anti-cancer properties. In the present study, we found that decursin inhibited cell viability in cultured human urinary bladder cancer 235J cells and colon cancer HCT116 cells. The inhibited proliferation was due to apoptotic induction, because both cells treated with decursin dose-dependently showed a sub-G1 phase accumulation and an increased cytoplasmic DNA-histone complex. Cell death caused by decursin was also associated with the down-regulation of anti-apoptotic factor Bcl-2 and the up-regulation of pro-apoptotic molecules cytochrome c, caspase 3 and Bax. Treatment of both types of cancer cells with decursin resulted in G1-phase cell cycle arrest, as revealed by FACS analyses. In addition, decursin increased protein levels of p21WAF1 with a decrease in cyclins and cyclin dependent kinases (CDKs). Furthermore, decursin induced the activation of extracellular signal-regulated kinases (ERK) in both cancer cell lines, with the notable exceptions of c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein (MAP) kinase. Finally, pretreatment with ERK-specific inhibitor PD98059 reversed decursin-induced p21WAF1 expression and decursin-inhibited cell growth. Thus, these findings suggest that decursin has potential therapeutic efficacy for the treatment of bladder and colon cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent635~641-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHApoptosis/drug effects*-
dc.subject.MESHBenzopyrans/pharmacology*-
dc.subject.MESHButyrates/pharmacology*-
dc.subject.MESHCaspase 3/metabolism-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHColonic Neoplasms/enzymology*-
dc.subject.MESHColonic Neoplasms/pathology-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p21/metabolism-
dc.subject.MESHCytochromes c/metabolism-
dc.subject.MESHDown-Regulation/drug effects-
dc.subject.MESHDrug Screening Assays, Antitumor-
dc.subject.MESHEnzyme Activation/drug effects-
dc.subject.MESHExtracellular Signal-Regulated MAP Kinases/metabolism*-
dc.subject.MESHG1 Phase/drug effects*-
dc.subject.MESHHumans-
dc.subject.MESHMAP Kinase Kinase 1/antagonists & inhibitors-
dc.subject.MESHMAP Kinase Kinase 1/metabolism-
dc.subject.MESHMAP Kinase Kinase 2/antagonists & inhibitors-
dc.subject.MESHMAP Kinase Kinase 2/metabolism-
dc.subject.MESHProtein Kinase Inhibitors/pharmacology-
dc.subject.MESHUp-Regulation/drug effects-
dc.subject.MESHUrinary Bladder Neoplasms/enzymology*-
dc.subject.MESHUrinary Bladder Neoplasms/pathology*-
dc.subject.MESHbcl-2-Associated X Protein/metabolism-
dc.titleDecursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorWun-Jae Kim-
dc.contributor.googleauthorSe-Jung Lee-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorSung-Kwon Moon-
dc.identifier.doi10.3892/ijmm_00000386-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ01132-
dc.identifier.eissn1791-244X-
dc.identifier.pmid20198313-
dc.identifier.urlhttp://www.spandidos-publications.com/ijmm/25/4/635?text=abstract-
dc.subject.keyworddecursin-
dc.subject.keywordbladder cancer cells-
dc.subject.keywordcolon cancer cells-
dc.subject.keywordG1-phase cell cycle arrest-
dc.subject.keywordapoptosis-
dc.subject.keywordp21WAF1-
dc.subject.keywordextracellular signalregulated kinases-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.citation.volume25-
dc.citation.number4-
dc.citation.startPage635-
dc.citation.endPage641-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol.25(4) : 635-641, 2010-
dc.identifier.rimsid37753-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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