Cited 33 times in
Human ES and iPS cells as cell sources for the treatment of Parkinson's disease: current state and problems
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김대성 | - |
dc.contributor.author | 김동욱 | - |
dc.date.accessioned | 2015-04-23T16:28:51Z | - |
dc.date.available | 2015-04-23T16:28:51Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0730-2312 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100660 | - |
dc.description.abstract | Cell therapy using human embryonic stem cells (hESCs) is a promising therapeutic option for Parkinson's disease (PD), an incurable neurodegenerative disease. A prerequisite for clinical application of hESCs for PD is an efficient and strict differentiation of hESCs into midbrain dopamine (mDA) neuron-like cells, which would be directly translated into high effectiveness of the therapy with minimum risk of undesirable side effects. Due to fruitful efforts from many laboratories, a variety of strategies for improving efficiency of dopaminergic differentiation from hESCs have been developed, mostly by optimizing culture conditions, genetic modification, and modulating intracellular signaling pathways. The rapid advances in the fields of dopaminergic differentiation of hESCs, prevention of tumor formation, and establishment of safe human induced pluripotent stem cells (hiPSCs) would open the door to highly effective, tumor-free, and immune rejection-free cell therapy for PD in the near future. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 292~301 | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Culture Techniques | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Transformation, Neoplastic | - |
dc.subject.MESH | Dopamine/metabolism | - |
dc.subject.MESH | Embryonic Stem Cells/metabolism | - |
dc.subject.MESH | Embryonic Stem Cells/pathology* | - |
dc.subject.MESH | Embryonic Stem Cells/transplantation | - |
dc.subject.MESH | Genetic Engineering | - |
dc.subject.MESH | Graft Rejection | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Induced Pluripotent Stem Cells/metabolism | - |
dc.subject.MESH | Induced Pluripotent Stem Cells/pathology* | - |
dc.subject.MESH | Induced Pluripotent Stem Cells/transplantation | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Neurons/metabolism | - |
dc.subject.MESH | Parkinson Disease/therapy* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Signal Transduction/physiology | - |
dc.subject.MESH | Stem Cell Transplantation* | - |
dc.title | Human ES and iPS cells as cell sources for the treatment of Parkinson's disease: current state and problems | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Min Ki Jee | - |
dc.contributor.googleauthor | Ji Hoon Kim | - |
dc.contributor.googleauthor | Yong Man Han | - |
dc.contributor.googleauthor | Sung Jun Jung | - |
dc.contributor.googleauthor | Kyung Sun Kang | - |
dc.contributor.googleauthor | Dong Wook Kim | - |
dc.contributor.googleauthor | Soo Kyung Kang | - |
dc.identifier.doi | 10.1002/jcb.22411 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00367 | - |
dc.contributor.localId | A00406 | - |
dc.relation.journalcode | J01303 | - |
dc.identifier.eissn | 1097-4644 | - |
dc.identifier.pmid | 20014069 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jcb.22411/abstract | - |
dc.subject.keyword | HUMAN ES/IPS CELLS | - |
dc.subject.keyword | DOPAMINE NEURON DIFFERENTIATION | - |
dc.subject.keyword | PAKINSON’S DISEASE | - |
dc.contributor.alternativeName | Kim, Dae Sung | - |
dc.contributor.alternativeName | Kim, Dong Wook | - |
dc.contributor.affiliatedAuthor | Kim, Dae Sung | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wook | - |
dc.citation.volume | 109 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 292 | - |
dc.citation.endPage | 301 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR BIOCHEMISTRY, Vol.109(2) : 292-301, 2010 | - |
dc.identifier.rimsid | 37728 | - |
dc.type.rims | ART | - |
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