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MicroRNA expression profile of gastrointestinal stromal tumors is distinguished by 14q loss and anatomic site

DC FieldValueLanguage
dc.contributor.author김호근-
dc.contributor.author노성훈-
dc.contributor.author형우진-
dc.date.accessioned2015-04-23T16:27:44Z-
dc.date.available2015-04-23T16:27:44Z-
dc.date.issued2010-
dc.identifier.issn0020-7136-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100626-
dc.description.abstractMicroRNAs are known to regulate gene expression. Although unique microRNA expression profiles have been reported in several tumors, little is known about microRNA expression profiles in GISTs. To evaluate the relationship between microRNA expression and clinicopathologic findings of GISTs, we analyzed the microRNA expression profiles of GISTs. We used fresh frozen tissues from 20 GISTs and analyzed KIT and PDGFRA mutations and chromosomal loss status. MicroRNA expression was analyzed using a microRNA chip containing 470 microRNAs. Using unsupervised hierarchical clustering analysis, we found four distinct microRNA expression patterns in our 20 GISTs. Six GISTs that did not have 14q loss formed a separate cluster. In the 14 GISTs with 14q loss, 5 small bowel GISTs formed a separate cluster and the remaining 9 GISTs could be divided into two groups according to frequent chromosomal losses and tumor risk. We found 73 microRNAs that were significantly down-regulated in the GISTs with 14q loss; 38 of these microRNAs are encoded on 14q. We also found many microRNAs that were down-regulated in small bowel and high-risk group GISTs. Most of the microRNAs down-regulated in the high-risk group and small bowel GISTs are known to be involved in tumor progression, specifically by stimulating mitogen-activated protein kinase (MAPK) and the cell cycle. The microRNA expression patterns of GISTs are closely related to the status of 14q loss, anatomic site, and tumor risk. These findings suggest that microRNA expression patterns can differentiate several subsets of GISTs.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1640~1650-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/genetics*-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHBlotting, Northern-
dc.subject.MESHBlotting, Western-
dc.subject.MESHChromosomes, Human, Pair 14/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGastrointestinal Stromal Tumors/genetics*-
dc.subject.MESHGastrointestinal Stromal Tumors/metabolism-
dc.subject.MESHGastrointestinal Stromal Tumors/pathology-
dc.subject.MESHGene Expression Profiling*-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHLoss of Heterozygosity*-
dc.subject.MESHMale-
dc.subject.MESHMicroRNAs/physiology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation/genetics-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.subject.MESHProto-Oncogene Proteins c-kit/genetics-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHReceptor, Platelet-Derived Growth Factor alpha/genetics-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.titleMicroRNA expression profile of gastrointestinal stromal tumors is distinguished by 14q loss and anatomic site-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorHee-Jung Choi-
dc.contributor.googleauthorHanna Lee-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorJi Eun Kwon-
dc.contributor.googleauthorHyun Ju Kang-
dc.contributor.googleauthorKwon Tae You-
dc.contributor.googleauthorHwanseok Rhee-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorYoung-Ki Paik-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorHoguen Kim-
dc.identifier.doi10.1002/ijc.24897-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01183-
dc.contributor.localIdA01281-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ01092-
dc.identifier.eissn1097-0215-
dc.identifier.pmid19795448-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/ijc.24897/abstract-
dc.subject.keywordmicroRNA-
dc.subject.keywordgastrointestinal stromal tumors-
dc.subject.keywordKIT-
dc.subject.keywordloss of14q-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.citation.volume126-
dc.citation.number7-
dc.citation.startPage1640-
dc.citation.endPage1650-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CANCER, Vol.126(7) : 1640-1650, 2010-
dc.identifier.rimsid37707-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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