Cited 16 times in
Effects of V279F in the Lp-PLA(2) gene on markers of oxidative stress and inflammation in Koreans
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-04-23T16:26:42Z | - |
dc.date.available | 2015-04-23T16:26:42Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100594 | - |
dc.description.abstract | BACKGROUND: A single nucleotide polymorphism (SNP), V279F, in the lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) gene is known to influence enzyme activity. It is unclear whether Lp-PLA(2) exerts pro- or antiatherogenic effects in humans. We investigated the interplay between V279F, Lp-PLA(2) activity, oxidative stress and inflammation. METHODS: We genotyped 2914 healthy Koreans (43-79years) for the Lp-PLA(2) V279F and measured anthropometric parameters, lipid profile, fatty acid composition, lipid peroxides, inflammatory markers and Lp-PLA(2) levels. RESULTS: Lp-PLA(2) activity was 24% lower in V/F subjects (n=641) than in those with the V/V genotype (n=2227). Enzyme activity was undetectable in F/F subjects. Lp-PLA(2) activity was positively correlated with LDL-cholesterol (r=0.134, P<0.001), ox-LDL (r=0.064, P<0.01), 8-epi-PGF(2alpha) (r=0.198, P<0.001), free fatty acid (r=0.082, P<0.001), and fibrinogen (r=0.112, P<0.01) levels. Additionally, ox-LDL, 8-epi-PGF(2alpha), free fatty acid, and fibrinogen levels were positively correlated with hs-CRP. V279F was associated with LDL-cholesterol and arachidonic acid (AA) in serum phospholipid. F/F subjects had lower LDL-cholesterol than V/V subjects (V/V: 120.9+/-0.69, V/F: 119.4+/-1.26, F/F: 109.2+/-4.84mg/dl, P=0.025). A significant association between the F/F genotype and increasing AA in serum phospholipids was found in subjects with high LDL-cholesterol (> or =130mg/dl) (P=0.003) but not in those with low LDL-cholesterol (<130mg/dl). F/F subjects in the high LDL-cholesterol group had CRP concentrations about three times higher than those with V/V or V/F genotypes (V/V: 1.25+/-0.09, V/F: 0.97+/-0.12, F/F: 3.20+/-0.88mg/dl, P<0.001). CONCLUSIONS: The recessive effects of Lp-PLA(2) V279F on LDL-cholesterol and significant correlations between Lp-PLA(2) activity and LDL-cholesterol, 8-epi-PGF(2alpha) and fibrinogen support a pro-oxidative or pro-atherogenic role for this enzyme. Paradoxically, the combination of the complete deficiency of Lp-PLA(2) activity and high LDL-cholesterol enhanced lipid peroxidation and inflammation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 486~493 | - |
dc.relation.isPartOf | CLINICA CHIMICA ACTA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 1-Alkyl-2-acetylglycerophosphocholine Esterase/genetics* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation/genetics* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxidative Stress/genetics* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.title | Effects of V279F in the Lp-PLA(2) gene on markers of oxidative stress and inflammation in Koreans | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jean Kyung Paik | - |
dc.contributor.googleauthor | Jey Sook Chae | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Tae-Sook Jeong | - |
dc.contributor.googleauthor | Sang-Hyun Lee | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1016/j.cca.2009.12.021 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00543 | - |
dc.identifier.eissn | 1873-3492 | - |
dc.identifier.pmid | 20080080 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009898110000069 | - |
dc.subject.keyword | Lp-PLA2V279F | - |
dc.subject.keyword | LDL-cholesterol | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Inflammation | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 411 | - |
dc.citation.number | 7-8 | - |
dc.citation.startPage | 486 | - |
dc.citation.endPage | 493 | - |
dc.identifier.bibliographicCitation | CLINICA CHIMICA ACTA, Vol.411(7-8) : 486-493, 2010 | - |
dc.identifier.rimsid | 36588 | - |
dc.type.rims | ART | - |
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