Cited 61 times in
Independent inverse relationship between serum lycopene concentration and arterial stiffness.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상학 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-04-23T16:26:40Z | - |
dc.date.available | 2015-04-23T16:26:40Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100593 | - |
dc.description.abstract | OBJECTIVE: Emerging evidence suggests a role of lycopene in the primary prevention of cardiovascular disease. This study aimed to investigate the association of serum lycopene concentration with brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness and markers of oxidative stress and inflammation. METHODS: healthy women (n=264, 31-75 yrs) were classified into tertiles according to serum lycopene concentration. Multivariate linear regression analyses were used to assess the relationship between serum lycopene and baPWV. RESULTS: Subjects in middle tertile (T2) and upper tertile (T3) had lower baPWV (1263+/-23 and 1265+/-14 cm/s vs. 1338+/-21 cm/s; p=0.009) and lower oxidized LDL (oxLDL) (53+/-3 and 55+/-3 U/L vs. 66+/-3 U/L; p<0.001) than those in lower tertile (T1). Subjects in T3 showed higher LDL particle size (24.3+/-0.08 nm vs. 24.0+/-0.07 nm, p=0.005) and lower C-reactive protein (hs-CRP) (0.80+/-0.25mg/dL vs. 1.27+/-0.24 mg/dL, p=0.015), compared with those in T1. Logistic regression analysis showed that baPWV decreased with the increment of lycopene concentration; log baPWV decreased by 0.21 cm/s (95% CI -0.168;-0.045, p=0.001) per unit change in lycopene. After adjustment for age, BMI, smoking, drinking, menopause and blood pressure, the estimated effect was attenuated by 35%, but remained statistically significant [-0.13 cm/s (95% CI -0.112;-0.018, p=0.006)]. Further adjustment for beta-carotene, alpha-tocopherol, oxLDL, LDL particle size, and hs-CRP increased the strength of the association [beta=-0.221 (95% CI -0.215;-0.012, p=0.029)]. CONCLUSION: This study supports the presence of an independent inverse relationship between circulating lycopene and baPWV. Additionally, reduced oxidative modification of LDL may be one of mediators on the mechanisms how lycopene reduces arterial stiffness | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 581~586 | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Arteries/metabolism* | - |
dc.subject.MESH | Arteries/pathology* | - |
dc.subject.MESH | Cardiovascular Diseases/blood | - |
dc.subject.MESH | Cardiovascular Diseases/metabolism | - |
dc.subject.MESH | Carotenoids/blood* | - |
dc.subject.MESH | Carotenoids/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation | - |
dc.subject.MESH | Lipoproteins, LDL/metabolism | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxidative Stress | - |
dc.subject.MESH | Oxygen/chemistry | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | alpha-Tocopherol/metabolism | - |
dc.subject.MESH | beta Carotene/metabolism | - |
dc.title | Independent inverse relationship between serum lycopene concentration and arterial stiffness. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Hyun Yang Yoe | - |
dc.contributor.googleauthor | Hyae Jin Kim | - |
dc.contributor.googleauthor | Ju Yeon Park | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Jin Hee Lee | - |
dc.contributor.googleauthor | Kang Pyo Lee | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2009.08.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A02833 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 19767001 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0021915009006340 | - |
dc.subject.keyword | Lycopene | - |
dc.subject.keyword | Arterial stiffness | - |
dc.subject.keyword | Branchial-ankle pulse wave velocity | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Inflammation | - |
dc.contributor.alternativeName | Lee, Sang Hak | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.citation.volume | 208 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 581 | - |
dc.citation.endPage | 586 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.208(2) : 581-586, 2010 | - |
dc.identifier.rimsid | 36587 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.