2 236

Cited 13 times in

Programmed death-1 (PD-1) gene polymorphisms lodged in the genetic predispositions of Kawasaki Disease

Authors
 Jin-Kyong Chun  ;  Dong Won Kang  ;  Byung Won Yoo  ;  Jeon-Soo Shin  ;  Dong Soo Kim 
Citation
 EUROPEAN JOURNAL OF PEDIATRICS, Vol.169(2) : 181-185, 2010 
Journal Title
 EUROPEAN JOURNAL OF PEDIATRICS 
ISSN
 0340-6199 
Issue Date
2010
MeSH
Adolescent ; Adult ; Antigens, CD/blood ; Antigens, CD/genetics* ; Apoptosis Regulatory Proteins/blood ; Apoptosis Regulatory Proteins/genetics* ; Child ; Child, Preschool ; DNA/genetics* ; Female ; Genetic Predisposition to Disease/genetics* ; Humans ; Incidence ; Lymphocyte Activation ; Male ; Mucocutaneous Lymph Node Syndrome/blood ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Mucocutaneous Lymph Node Syndrome/genetics* ; Odds Ratio ; Polymerase Chain Reaction ; Polymorphism, Genetic* ; Programmed Cell Death 1 Receptor ; Republic of Korea/epidemiology ; Retrospective Studies ; Young Adult
Keywords
Programmed death-1 gene ; Kawasaki disease ; Vasculitis ; Single nucleotide polymorphism
Abstract
The purpose of this study is to investigate the association of programmed death-1 gene (PD-1) polymorphisms with genetic predispositions to Kawasaki disease (KD). A total of 73 patients with KD and 100 healthy controls were enrolled from 2007 to 2008. Two single nucleotide polymorphisms of the PD-1 gene, rs41386349 and rs2227981, were analyzed. Higher T allele frequency of rs41386349 was found in the patient group than the control group (p = 0.007, odds ratio (OR) = 1.9, 95% CI = 1.2-2.9). PD-1 rs2227981 polymorphism was not significant in patients with KD comparing with the control group (p = 0.4, OR = 1.2 (0.8-1.9)). Furthermore, no difference of PD-1 polymorphisms between patients with coronary artery dilatation (CAD) and those without CAD was found. Our data support the possibility that PD-1 gene polymorphism may be related with the genetic susceptibility of KD in Korean population.
Full Text
http://link.springer.com/article/10.1007%2Fs00431-009-1002-4
DOI
10.1007/s00431-009-1002-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Yoo, Byung Won(류병원) ORCID logo https://orcid.org/0000-0001-6895-1484
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100564
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse