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Comparison of neointimal coverage of sirolimus-eluting stents and paclitaxel-eluting stents using optical coherence tomography at 9 months after implantation.

 Jin-Sun Kim  ;  Jung-Sun Kim  ;  Tae Hoon Kim  ;  Chunyu Fan  ;  Jung Myung Lee  ;  Woong Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Myeong-Ki Hong  ;  Yangsoo Jang 
 CIRCULATION JOURNAL, Vol.74(2) : 320-326, 2010 
Journal Title
Issue Date
Aged ; Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon, Coronary/instrumentation* ; Cardiovascular Agents/administration & dosage* ; Coronary Angiography ; Coronary Artery Disease/pathology ; Coronary Artery Disease/therapy* ; Coronary Vessels/pathology* ; Drug-Eluting Stents* ; Female ; Humans ; Male ; Middle Aged ; Paclitaxel/administration & dosage* ; Prosthesis Design ; Registries ; Sirolimus/administration & dosage* ; Thrombosis/etiology ; Thrombosis/pathology ; Time Factors ; Tomography, Optical Coherence* ; Treatment Outcome ; Tunica Intima/pathology*
Drug-eluting stent ; Optical coherence ; Paclitaxel ; Sirolimus ; Tomography
BACKGROUND: The differences between using sirolimus-eluting stents (SESs) and paclitaxel-eluting stents (PESs) in the vascular response at 9 months after implantation were examined with optical coherence tomography (OCT).

METHODS AND RESULTS: OCT was carried out in 33 SESs [33 patients, 19 with acute coronary syndrome (ACS) and 14 with stable angina pectoris (SAP)] and 27 PESs (27 patients, 15 with ACS and 12 with SAP) at 9 months after stent implantation. Stent strut coverage and apposition at each strut were evaluated. The frequency of uncovered struts was significantly higher in SES (12.5+/-15.2 vs 4.9+/-7.9 %, P=0.01). The incidence of complete covered stents with neointima was 9.1% (3/33) in SES and 29.6% (8/27) in PES (P=0.05). The pattern of neointima in PES was more heterogeneous than that in SES (1.3+/-0.5 for SES vs 2.0+/-0.6 for PES, P<0.001). The intracoronary thrombus was frequently detected in SES [10 (30.3%) in SES vs 5 (18.5%) in PES, P=0.29].

CONCLUSIONS: Uncovered struts were frequently observed in SES, but the pattern of neointima was more heterogeneous in PES at 9 months. In addition, stent coverage was incomplete in both stent groups at 9 months after stent implantation.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Kim, Jin Sun(김진선)
Kim, Tae-Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-4200-3456
Lee, Jung Myung(이정명)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
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