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Population genetic study of four closely-linked X-STR trios in Koreans

Authors
 Jeong Eun Sim  ;  Hwan Young Lee  ;  Woo Ick Yang  ;  Kyoung-Jin Shin 
Citation
 MOLECULAR BIOLOGY REPORTS, Vol.37(1) : 333-337, 2010 
Journal Title
MOLECULAR BIOLOGY REPORTS
ISSN
 0301-4851 
Issue Date
2010
MeSH
Alleles ; Asian Continental Ancestry Group/genetics* ; Base Sequence ; Chromosomes, Human, X/genetics* ; Female ; Forensic Genetics ; Gene Frequency/genetics ; Genetic Loci/genetics* ; Genetics, Population* ; Haplotypes/genetics ; Humans ; Male ; Microsatellite Repeats/genetics* ; Molecular Sequence Data ; Republic of Korea
Keywords
X-STR ; DXS10079 ; DXS10103 ; DXS10146 ; DXS10148 ; Koreans
Abstract
We investigated four X chromosomal short tandem repeat (X-STR) markers (DXS10079, DXS10103, DXS10146, and DXS10148) in 450 unrelated Koreans (300 males and 150 females), and evaluated their forensic usage in relation to the four X-STR linkage groups. Forensic statistical parameters for these X-STR markers indicated that they are highly informative for forensic application in Koreans. No significant deviations from Hardy-Weinberg equilibrium were observed in any of the four X-STR markers. In addition, we present haplotypes and their frequency data for four linkage groups each comprised of three X-STRs (DXS10148-DXS10135-DXS8378, DXS7132-DXS10079-DXS10074, DXS10103-HPRTB-DXS10101, and DXS10146-DXS10134-DXS7423) in 300 males. Haplotype diversity values in the four linkage trios were all higher than 0.98, and 77.1% of all haplotypes showed a frequency less than 0.01. Therefore, the four closely-linked X-STR trios will contribute to complex kinship testing in Koreans.
Full Text
http://link.springer.com/article/10.1007%2Fs11033-009-9733-x
DOI
10.1007/s11033-009-9733-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
Sim, Jeong Eun(심정은)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Hwan Young(이환영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100480
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