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Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance
DC Field | Value | Language |
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dc.contributor.author | 임범진 | - |
dc.date.accessioned | 2015-04-23T16:22:52Z | - |
dc.date.available | 2015-04-23T16:22:52Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100478 | - |
dc.description.abstract | Molecules associated with tumor invasion and metastasis have been actively investigated, but their prognostic significance has been variously reported by investigators. We evaluated the expression of matrix metalloproteinase (MMP)-1, MMP-2, MMP-3, MMP-9, MMP-10, tissue inhibitor of MMPs (TIMP)-1, TIMP-2, β-catenin, E-cadherin and cyclooxygenase-2 (COX-2) in 43 cases of non-small cell lung cancer (NSCLC). Immunohistochemistry of each marker was performed on tissue microarray paraffin blocks, and the results were determined by a semi-quantitative method using an intensity score (0-3) and percentage score (0-3). The expression scores of each marker were correlated with TNM stage and patient survival data. The expression of MMP-3 and COX-2 was significantly increased in higher stage tumors (P<0.001 and P=0.046, respectively), while a correlation with patient survival length was observed for MMP-1 and COX-2 (P=0.034 and 0.019, respectively). All stage I or II cases with increased MMP-1 expression succumbed to NSCLC within 34.1 months. Cases with low expression of both MMP-1 and COX-2 had a significantly longer survival time than cases with high expression of either of the two markers (P=0.002). These results suggest that MMP-1 and COX-2 are plausible candidate survival markers for NSCLC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 43~49 | - |
dc.relation.isPartOf | MOLECULAR MEDICINE REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Beom J. Lim | - |
dc.contributor.googleauthor | Sung S. Jung | - |
dc.contributor.googleauthor | Song Y. Choi | - |
dc.contributor.googleauthor | Choong S. Lee | - |
dc.identifier.doi | 10.3892/mmr_00000216 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03363 | - |
dc.relation.journalcode | J02261 | - |
dc.identifier.eissn | 1791-3004 | - |
dc.identifier.pmid | 21472198 | - |
dc.identifier.url | http://www.spandidos-publications.com/mmr/3/1/43?text=abstract | - |
dc.subject.keyword | carcinoma | - |
dc.subject.keyword | non-small cell lung | - |
dc.subject.keyword | matrix metallopro-teinases | - |
dc.subject.keyword | cyclooxygenase-2 | - |
dc.subject.keyword | survival analysis | - |
dc.contributor.alternativeName | Lim, Beom Jin | - |
dc.contributor.affiliatedAuthor | Lim, Beom Jin | - |
dc.citation.volume | 3 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 43 | - |
dc.citation.endPage | 49 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE REPORTS, Vol.3(1) : 43-49, 2010 | - |
dc.identifier.rimsid | 36512 | - |
dc.type.rims | ART | - |
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