Cited 76 times in
Increased immunoendocrine cells in intestinal mucosa of postinfectious irritable bowel syndrome patients 3 years after acute Shigella infection--an observation in a small case control study
DC Field | Value | Language |
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dc.contributor.author | 박효진 | - |
dc.contributor.author | 이상인 | - |
dc.date.accessioned | 2015-04-23T16:21:50Z | - |
dc.date.available | 2015-04-23T16:21:50Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100447 | - |
dc.description.abstract | PURPOSE: Postinfectiously irritable bowel syndrome (PI-IBS) develops in 3-30% of individuals with bacterial gastroenteritis. Recent studies demonstrated increases in inflammatory components in gut mucosa of PI-IBS patients even after complete resolution of infection. We aimed to investigate histological changes in colon and rectum of PI-IBS subjects after long term period of infection. MATERIALS AND METHODS: We recruited PI-IBS subjects who had been diagnosed IBS after complete resolution of enteritis caused by shigellosis outbreak 3 years earlier. We compared unmatched four groups, PI-IBS (n = 4), non PI-IBS (n = 7), D-IBS (n = 7, diarrhea predominant type) and healthy controls (n = 10). All of them underwent colonoscopic biopsy at three areas, including descending colon (DC), sigmoid colon (SC) and rectum, which were assessed for 5-hydroxytryptamine (5-HT)/peptide YY (PYY)-containing enterochromaffin (EC) cell, intraepithelial (IEL) and lamina propria T lymphocyte (CD3), CD8 lymphocytes, mast cells and CD68/calprotectin+ macrophages. RESULTS: All subjects had no structural or gross abnormalities at colonoscopy. In PI-IBS, 5-HT containing EC cells, PYY containing EC cells, IELs, CD3 lymphocytes, CD8 lymphocytes, mast cells, and CD68 + macrophages were increased compared to control (p < 0.05). In D-IBS, PYY containing EC cells, IELs, and CD3 lymphocytes were increased compared to control (p < 0.05). In PI-IBS, 5-HT containing EC cells tended to increase and PYY containing EC cells, CD8 lymphocytes, mast cells, and CD68+ macrophages were increased compared to non PI-IBS (p < 0.05). Calprotectin + marcrophages were decreased in PI-IBS, non PI-IBS and IBS compared to control. CONCLUSION: The immunoendocrine cells were sporadically increased in PI-IBS, non PI-IBS and D-IBS compared with control. Our findings in a very small number of patients suggest that mucosal inflammation may play a role in long-term PI-IBS, and that other sub-groups of IBS and larger scale studies are needed to confirm this observation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 45~51 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antigens, CD/metabolism | - |
dc.subject.MESH | Antigens, Differentiation, Myelomonocytic/metabolism | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/cytology | - |
dc.subject.MESH | Case-ControlStudies | - |
dc.subject.MESH | Colon, Descending/pathology | - |
dc.subject.MESH | Colon, Sigmoid/pathology | - |
dc.subject.MESH | Colonoscopy | - |
dc.subject.MESH | Dysentery, Bacillary/complications* | - |
dc.subject.MESH | EnterochromaffinCells/cytology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | IntestinalMucosa/pathology* | - |
dc.subject.MESH | IrritableBowelSyndrome/metabolism | - |
dc.subject.MESH | IrritableBowelSyndrome/pathology* | - |
dc.subject.MESH | Macrophages/cytology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | MastCells/cytology | - |
dc.subject.MESH | Peptide YY/metabolism | - |
dc.subject.MESH | Rectum/pathology | - |
dc.subject.MESH | Serotonin/metabolism | - |
dc.title | Increased immunoendocrine cells in intestinal mucosa of postinfectious irritable bowel syndrome patients 3 years after acute Shigella infection--an observation in a small case control study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hee Sun Kim | - |
dc.contributor.googleauthor | Jung Hyun Lim | - |
dc.contributor.googleauthor | Hyojin Park | - |
dc.contributor.googleauthor | Sang In Lee | - |
dc.identifier.doi | 10.3349/ymj.2010.51.1.45 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01774 | - |
dc.contributor.localId | A02828 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 20046513 | - |
dc.subject.keyword | Post infectiousirritablebowelsyndrome | - |
dc.subject.keyword | T lymphocyte | - |
dc.subject.keyword | enterochromaffin cell | - |
dc.subject.keyword | macrophage | - |
dc.subject.keyword | mast cell | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.alternativeName | Lee, Sang In | - |
dc.contributor.affiliatedAuthor | Park, Hyo Jin | - |
dc.contributor.affiliatedAuthor | Lee, Sang In | - |
dc.citation.volume | 51 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 51 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.51(1) : 45-51, 2010 | - |
dc.identifier.rimsid | 36495 | - |
dc.type.rims | ART | - |
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