363 257

Cited 44 times in

Resective pediatric epilepsy surgery in Lennox-Gastaut syndrome

DC FieldValueLanguage
dc.contributor.author강훈철-
dc.contributor.author김동석-
dc.contributor.author김태승-
dc.contributor.author김흥동-
dc.contributor.author심규원-
dc.contributor.author이윤진-
dc.contributor.author이윤호-
dc.contributor.author이준수-
dc.date.accessioned2015-04-23T16:21:14Z-
dc.date.available2015-04-23T16:21:14Z-
dc.date.issued2010-
dc.identifier.issn0031-4005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100429-
dc.description.abstractOBJECTIVE: The objective of this study was to evaluate the role of resective pediatric epilepsy surgery for Lennox-Gastaut syndrome (LGS). METHODS: We analyzed clinical data of 27 children and adolescents who had LGS and underwent resective epilepsy surgery despite abundant (>30% of preoperative interictal and/or ictal epileptiform discharges) generalized or generalized contralateral maximal and multiregional electroencephalogram abnormalities. RESULTS: On high-resolution MRI, cerebral lesions were noted in 23 (85.2%) patients but not in 4 (14.8%) patients. The age of patients at the time of surgery was between 1.7 and 17.3 years (mean: 7.8 years). Surgeries were lobar or multilobar resection in 21 (77.8%) patients and hemispherotomy in 6 (22.2%). At a mean of 33.1 months' postoperative follow-up, 16 (59.3%) patients had no seizures and 4 (14.8%) had infrequent seizures. Of 4 patients without brain abnormalities found on MRI, 2 patients became seizure-free after resective surgery was performed on the basis of electrophysiologic studies and concordant results in other multimodal neuroimages. Malformation of cortical development was the most common pathology and was seen in 20 (74.1%) patients, but 2 (7.4% patients) did not show any abnormal pathology. Sixteen (72.7%) patients, including 14 who had no seizures and 2 who had infrequent seizures after surgery, showed an increase in developmental quotient. No clinical profile was significantly associated with postoperative seizure-free rate. CONCLUSIONS: Resective epilepsy surgery should be considered for children with LGS, despite abundant generalized and multiregional electroencephalogram abnormalities.-
dc.description.statementOfResponsibilityopen-
dc.format.extentE58~E66-
dc.relation.isPartOfPEDIATRICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHCerebral Cortex/abnormalities*-
dc.subject.MESHCerebral Cortex/surgery-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCognition Disorders/diagnosis-
dc.subject.MESHCognition Disorders/surgery-
dc.subject.MESHCohort Studies-
dc.subject.MESHElectroencephalography/methods-
dc.subject.MESHEpilepsy, Generalized/diagnosis*-
dc.subject.MESHEpilepsy, Generalized/mortality-
dc.subject.MESHEpilepsy, Generalized/surgery*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMagnetic Resonance Imaging/methods-
dc.subject.MESHMale-
dc.subject.MESHNeurosurgical Procedures/methods*-
dc.subject.MESHPatient Selection-
dc.subject.MESHPreoperative Care/methods-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSurvival Rate-
dc.subject.MESHSyndrome-
dc.subject.MESHTreatment Outcome-
dc.titleResective pediatric epilepsy surgery in Lennox-Gastaut syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorYun Jin Lee-
dc.contributor.googleauthorHoon-Chul Kang-
dc.contributor.googleauthorJoon Soo Lee-
dc.contributor.googleauthorShin Hye Kim-
dc.contributor.googleauthorDong-Seok Kim-
dc.contributor.googleauthorKyu-Won Shim-
dc.contributor.googleauthorYun-Ho Lee-
dc.contributor.googleauthorTae Seung Kim-
dc.contributor.googleauthorHeung Dong Kim-
dc.identifier.doi10.1542/peds.2009-0566-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00102-
dc.contributor.localIdA00402-
dc.contributor.localIdA01071-
dc.contributor.localIdA01208-
dc.contributor.localIdA02187-
dc.contributor.localIdA03026-
dc.contributor.localIdA03030-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ02496-
dc.identifier.eissn1098-4275-
dc.identifier.pmid20008422-
dc.subject.keywordLennox-Gastaut syndrome-
dc.subject.keywordepilepsy surgery-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.alternativeNameKim, Tai Seung-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.alternativeNameShim, Kyu Won-
dc.contributor.alternativeNameLee, Yun Jin-
dc.contributor.alternativeNameLee, Yun Ho-
dc.contributor.alternativeNameLee, Joon Soo-
dc.contributor.affiliatedAuthorKang, Hoon Chul-
dc.contributor.affiliatedAuthorKim, Dong Seok-
dc.contributor.affiliatedAuthorKim, Tai Seung-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.contributor.affiliatedAuthorShim, Kyu Won-
dc.contributor.affiliatedAuthorLee, Yun Jin-
dc.contributor.affiliatedAuthorLee, Yun Ho-
dc.contributor.affiliatedAuthorLee, Joon Soo-
dc.citation.volume125-
dc.citation.number1-
dc.citation.startPage58-
dc.citation.endPage66-
dc.identifier.bibliographicCitationPEDIATRICS, Vol.125(1) : 58-66, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.