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Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesis

Authors
 Jennifer K. Liang  ;  Jinwoong Bok  ;  Doris K. Wu 
Citation
 DEVELOPMENTAL BIOLOGY, Vol.337(2) : 324-334, 2010 
Journal Title
 DEVELOPMENTAL BIOLOGY 
ISSN
 0012-1606 
Issue Date
2010
MeSH
Animals ; Body Patterning ; Chick Embryo ; Chickens ; Cochlear Duct/embryology ; Ear, Inner/embryology* ; Mesoderm/embryology* ; Mesoderm/transplantation ; Morphogenesis* ; Notochord/embryology ; Organ Size ; Rhombencephalon/embryology*
Keywords
Inner ear morphogenesis ; Axial specification ; Hindbrain ; Rhombomere ; Mesenchyme ; Basilar papilla ; Semicircular canals ; Chicken
Abstract
A mature inner ear is a complex structure consisting of vestibular and auditory components. Microsurgical ablations, rotations, and translocations were performed in ovo to identify the tissues that control inner ear morphogenesis. We show that mesenchyme/ectoderm adjacent to the developing ear specifically governs the shape of vestibular components - the semicircular canals and ampullae - by conferring anteroposterior axial information to these structures. In contrast, removal of individual hindbrain rhombomeres adjacent to the developing ear preferentially affects the growth and morphogenesis of the auditory subdivision, the cochlear duct, or basilar papilla. Removal of rhombomere 5 affects cochlear duct growth, while rhombomere 6 removal affects cochlear growth and morphogenesis. Rotating rhombomeres 5 and 6 along the anteroposterior axis also impacts cochlear duct morphogenesis but has little effect on the vestibular components. Our studies indicate that discrete tissues, acting at a distance, control the morphogenesis of distinct elements of the inner ear. These results provide a basis for identifying factors that are essential to vestibular and auditory development in vertebrates.
Full Text
http://www.sciencedirect.com/science/article/pii/S0012160609013372
DOI
10.1016/j.ydbio.2009.11.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Bok, Jin Woong(복진웅) ORCID logo https://orcid.org/0000-0003-1958-1872
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100422
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