Cited 99 times in
Frequent central nervous system failure after clinical benefit with epidermal growth factor receptor tyrosine kinase inhibitors in Korean patients with nonsmall-cell lung cancer.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세규 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 문진욱 | - |
dc.contributor.author | 박인규 | - |
dc.contributor.author | 이영주 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 조병철 | - |
dc.contributor.author | 최혜진 | - |
dc.date.accessioned | 2015-04-23T16:20:37Z | - |
dc.date.available | 2015-04-23T16:20:37Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0008-543X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100410 | - |
dc.description.abstract | BACKGROUND: We investigated the risk of central nervous system (CNS) failure after clinical benefit with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in Korean patients with nonsmall-cell lung cancer (NSCLC) METHODS: We retrospectively evaluated the pattern of disease progression of 287 advanced NSCLC patients who were treated with gefitinib or erlotinib. Patients whose best tumor response was complete response, partial response, or stable disease (> or =90 days) were classified into the group receiving clinical benefit with these drugs. RESULTS: The clinical benefit group had a higher incidence of CNS failure as an initial progression, compared with the non-clinical benefit group (26% vs 4%; P < .001). Isolated CNS failure was also more frequent in the clinical benefit group than in the non-clinical benefit group (13% vs 1%; P < .001). In a multivariate analysis, clinical benefit with EGFR-TKIs significantly increased the risk of isolated CNS failure, with an adjusted hazard ratio of 10.9 (95% confidence interval [CI], 1.4-29.1, P = .01). In patients with isolated CNS failure, the median time from initial intracranial failure to extracranial failure was 9.9 months (95% CI, 1.9-21.9 months) and to death was 12.9 months (95% CI, 3.3-22.5 months). CONCLUSIONS: The CNS was frequently the initial failure site after clinical benefit with EGFR-TKIs in Korean NSCLC patients. Patients with isolated CNS failure showed durable extracranial control after cranial progression. A role for close surveillance of the CNS during EGFR-TKI treatment or prophylactic measures appears worthy of further study in these patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1336~1343 | - |
dc.relation.isPartOf | CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use* | - |
dc.subject.MESH | Asian Continental Ancestry Group* | - |
dc.subject.MESH | Carcinoma, Non-Small-CellLung/drug therapy* | - |
dc.subject.MESH | CentralNervousSystemNeoplasms/secondary* | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Erlotinib Hydrochloride | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | ProteinKinaseInhibitors/therapeutic use* | - |
dc.subject.MESH | Quinazolines/therapeutic use | - |
dc.subject.MESH | Receptor,EpidermalGrowthFactor/antagonists &inhibitors* | - |
dc.title | Frequent central nervous system failure after clinical benefit with epidermal growth factor receptor tyrosine kinase inhibitors in Korean patients with nonsmall-cell lung cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Young Joo Lee | - |
dc.contributor.googleauthor | Hye Jin Choi | - |
dc.contributor.googleauthor | Se Kyu Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Jin Wook Moon | - |
dc.contributor.googleauthor | In Kyu Park | - |
dc.contributor.googleauthor | Joo-Hang Kim | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.identifier.doi | 10.1002/cncr.24877 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01387 | - |
dc.contributor.localId | A01625 | - |
dc.contributor.localId | A02960 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A04219 | - |
dc.relation.journalcode | J00434 | - |
dc.identifier.eissn | 1097-0142 | - |
dc.identifier.pmid | 20066717 | - |
dc.subject.keyword | nonsmall cell lung cancer | - |
dc.subject.keyword | epidermal growth factor receptor | - |
dc.subject.keyword | central nervous system | - |
dc.subject.keyword | recurrence | - |
dc.subject.keyword | brain‐blood‐barrier | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Moon, Jin Wook | - |
dc.contributor.alternativeName | Park, In Kyu | - |
dc.contributor.alternativeName | Lee, Young Joo | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.alternativeName | Choi, Hye Jin | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Moon, Jin Wook | - |
dc.contributor.affiliatedAuthor | Park, In Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Young Joo | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Choi, Hye Jin | - |
dc.citation.volume | 116 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1336 | - |
dc.citation.endPage | 1343 | - |
dc.identifier.bibliographicCitation | CANCER, Vol.116(5) : 1336-1343, 2010 | - |
dc.identifier.rimsid | 36468 | - |
dc.type.rims | ART | - |
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