Cited 8 times in
Weekly 5-fluorouracil plus cisplatin for concurrent chemoradiotherapy in patients with locally advanced head and neck cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영주 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 조병철 | - |
dc.contributor.author | 최은창 | - |
dc.contributor.author | 최혜진 | - |
dc.contributor.author | 김귀언 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 손주혁 | - |
dc.date.accessioned | 2015-04-23T16:20:28Z | - |
dc.date.available | 2015-04-23T16:20:28Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100406 | - |
dc.description.abstract | BACKGROUND: In locally advanced head and neck cancer, concurrent chemoradiotherapy (CRT) with combined 5-fluorouracil (5-FU) and cisplatin has increased acute toxicities as well as survival. Once-weekly chemotherapeutic administration schedule may reduce severe toxicities. Thus, we investigated CRT using weekly administration of 5-FU-cisplatin in locally advanced head and neck cancer. METHODS: In a single-arm, phase II study, CRT included radiation (70.0 Gy/35 fr) and weekly 5-FU (750 mg/m2) and cisplatin (20 mg/m2). RESULTS: Thirty-two patients completed planned radiation. Thirteen (41%) achieved complete response, and 16 (50%) partial response. Twelve patients (38%) experienced acute grade 3 toxicities. Grade 3 mucositis, which was the most common toxicity, developed in 5 (16%) patients. The survival rates at 1 and 2 years were 81% and 76%, respectively. The progression-free survival rates at 1 and 2 years were 69% and 66%, respectively. CONCLUSIONS: We demonstrated weekly 5-FU-cisplatin with conventional radiotherapy was efficacious and feasible with high compliance rate in locally advanced head and neck cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 235~243 | - |
dc.relation.isPartOf | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/mortality | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/therapy* | - |
dc.subject.MESH | Cisplatin/administration & dosage | - |
dc.subject.MESH | Cisplatin/adverse effects* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorouracil/administration & dosage* | - |
dc.subject.MESH | Fluorouracil/adverse effects | - |
dc.subject.MESH | Head and Neck Neoplasms/mortality | - |
dc.subject.MESH | Head and Neck Neoplasms/pathology | - |
dc.subject.MESH | Head and Neck Neoplasms/therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mucositis/etiology | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Radiotherapy, Adjuvant | - |
dc.subject.MESH | Radiotherapy, Conformal/adverse effects | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Weekly 5-fluorouracil plus cisplatin for concurrent chemoradiotherapy in patients with locally advanced head and neck cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Young Joo Lee | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.contributor.googleauthor | Gwi Eon Kim | - |
dc.contributor.googleauthor | Hye Jin Choi | - |
dc.contributor.googleauthor | Eun Chang Choi | - |
dc.contributor.googleauthor | Joo Hyuk Sohn | - |
dc.contributor.googleauthor | Joo-Hang Kim | - |
dc.identifier.doi | 10.1002/hed.21177 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02960 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A03822 | - |
dc.contributor.localId | A04161 | - |
dc.contributor.localId | A04219 | - |
dc.contributor.localId | A00321 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01995 | - |
dc.relation.journalcode | J00963 | - |
dc.identifier.eissn | 1097-0347 | - |
dc.identifier.pmid | 19572288 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/hed.21177/abstract | - |
dc.subject.keyword | head-and-neck cancer | - |
dc.subject.keyword | chemotherapy | - |
dc.subject.keyword | radiotherapy | - |
dc.subject.keyword | 5-fluorouracil | - |
dc.subject.keyword | cisplatin | - |
dc.contributor.alternativeName | Lee, Young Joo | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.alternativeName | Choi, Eun Chang | - |
dc.contributor.alternativeName | Choi, Hye Jin | - |
dc.contributor.alternativeName | Kim, Gwi Eon | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Sohn, Joo Hyuk | - |
dc.contributor.affiliatedAuthor | Lee, Young Joo | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Choi, Eun Chang | - |
dc.contributor.affiliatedAuthor | Choi, Hye Jin | - |
dc.contributor.affiliatedAuthor | Kim, Gwi Eon | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Sohn, Joo Hyuk | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 235 | - |
dc.citation.endPage | 243 | - |
dc.identifier.bibliographicCitation | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.32(2) : 235-243, 2010 | - |
dc.identifier.rimsid | 36467 | - |
dc.type.rims | ART | - |
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