Cited 39 times in
Expression of Receptor Activator of Nuclear Factor Kappa-B as a Poor Prognostic Marker in Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | 박형석 | - |
dc.date.accessioned | 2015-01-06T17:38:35Z | - |
dc.date.available | 2015-01-06T17:38:35Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100360 | - |
dc.description.abstract | PURPOSE: Receptor activator of nuclear factor kappa-B and its ligand (RANK/RANKL) and Osteoprotegerin (OPG) are key molecules for regulating osteoclastic activity in bone. However, little is known about the role of RANK-related molecules in breast cancer prognosis. We aimed to evaluate RANK, RANKL, and OPG expression and the associated clinical impact in breast cancer. METHODS: Tissue microarray (TMA) from 185 patients with primary breast cancer was established. Immunohistochemistry for RANK, RANKL, and OPG was performed. Clinicopathologic features and survival outcomes associated with expression of RANK, RANKL, and OPG were analyzed. RESULTS: RANK, RANKL, and OPG were expressed in 74.1%, 78.4%, and 45.9% of patients, respectively. RANKL expression was associated with lower Ki-67 level. OPG expression was related to small tumor size, node negativity, and low Ki-67. There was no significant difference in clinicopathologic features between tumors with RANK and those without RANK. RANK expression was significantly associated with poor disease-free survival in univariate analysis (P = 0.04) and multivariate analysis (P = 0.02). RANKL expression was associated with improved skeletal disease-free survival in multivariate analysis (P = 0.03). CONCLUSIONS: The RANK/RANKL pathway regulated by OPG may have a role in predicting progression and prognosis of breast cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 807~812 | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/mortality | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoenzyme Techniques | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Neoplasm Recurrence, Local/metabolism* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/mortality | - |
dc.subject.MESH | Neoplasm Recurrence, Local/pathology | - |
dc.subject.MESH | Osteoprotegerin/metabolism* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | RANK Ligand/metabolism* | - |
dc.subject.MESH | Receptor Activator of Nuclear Factor-kappa B/metabolism* | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Expression of Receptor Activator of Nuclear Factor Kappa-B as a Poor Prognostic Marker in Breast Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Hyung Seok Park | - |
dc.contributor.googleauthor | Ahwon Lee | - |
dc.contributor.googleauthor | Byung Joo Chae | - |
dc.contributor.googleauthor | Ja-Seong Bae | - |
dc.contributor.googleauthor | Byung Joo Song | - |
dc.contributor.googleauthor | Sang Seol Jung | - |
dc.identifier.doi | 10.1002/jso.23737 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01753 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 25111682 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jso.23737/abstract | - |
dc.subject.keyword | RANK ligand | - |
dc.subject.keyword | breast neoplasms | - |
dc.subject.keyword | osteoprotegerin | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | receptor activator of nuclear factor-kappa B | - |
dc.subject.keyword | survival | - |
dc.contributor.alternativeName | Park, Hyung Seok | - |
dc.contributor.affiliatedAuthor | Park, Hyung Seok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 110 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 807 | - |
dc.citation.endPage | 812 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.110(7) : 807-812, 2014 | - |
dc.identifier.rimsid | 49578 | - |
dc.type.rims | ART | - |
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