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Hyponatremia as a predictor of mortality in peritoneal dialysis patients

DC Field Value Language
dc.contributor.author강신욱-
dc.contributor.author류근우-
dc.contributor.author박정탁-
dc.contributor.author강이화-
dc.contributor.author김영리-
dc.contributor.author김형우-
dc.contributor.author유태현-
dc.contributor.author장태익-
dc.contributor.author최규헌-
dc.contributor.author한대석-
dc.contributor.author한승혁-
dc.date.accessioned2015-01-06T17:36:15Z-
dc.date.available2015-01-06T17:36:15Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100289-
dc.description.abstractBACKGROUND AND AIM: Hyponatremia is common in patients with chronic kidney disease and is associated with increased mortality in hemodialysis patients. However, few studies have addressed this issue in peritoneal dialysis (PD) patients. METHODS: This prospective observational study included a total of 441 incident patients who started PD between January 2000 and December 2005. Using time-averaged serum sodium (TA-Na) levels, we aimed to investigate whether hyponatremia can predict mortality in these patients. RESULTS: Among the baseline parameters, serum sodium level was positively associated with serum albumin (β = 0.145; p = 0.003) and residual renal function (RRF) (β = 0.130; p = 0.018) and inversely associated with PD ultrafiltration (β = -0.114; p = 0.024) in a multivariable linear regression analysis. During a median follow-up of 34.8 months, 149 deaths were recorded. All-cause death occurred in 81 (55.9%) patients in the lowest tertile compared to 37 (25.0%) and 31 (20.9%) patients in the middle and highest tertiles, respectively. After adjusting for multiple potentially confounding covariates, increased TA-Na level was associated with a significantly decreased risk of all-cause (HR per 1 mEq/L increase, 0.79; 95% CI, 0.73-0.86; p<0.001) and infection-related (HR per 1 mEq/L increase, 0.77; 95% CI, 0.70-0.85; p<0.001) deaths. CONCLUSIONS: This study showed that hyponatremia is an independent predictor of mortality in PD patients. Nevertheless, whether correcting hyponatremia improves patient survival is unknown. Future interventional studies should address this question more appropriately.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyponatremia/diagnosis*-
dc.subject.MESHHyponatremia/etiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPeritoneal Dialysis/adverse effects*-
dc.subject.MESHPeritoneal Dialysis/mortality-
dc.subject.MESHRenal Insufficiency, Chronic/complications-
dc.subject.MESHRenal Insufficiency, Chronic/diagnosis-
dc.subject.MESHRenal Insufficiency, Chronic/therapy-
dc.titleHyponatremia as a predictor of mortality in peritoneal dialysis patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorTae Ik Chang-
dc.contributor.googleauthorYung Ly Kim-
dc.contributor.googleauthorHyungwoo Kim-
dc.contributor.googleauthorGeun Woo Ryu-
dc.contributor.googleauthorEa Wha Kang-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorSug Kyun Shin-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorDae Suk Han-
dc.contributor.googleauthorSeung Hyeok Han-
dc.identifier.doi10.1371/journal.pone.0111373-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00053-
dc.contributor.localIdA01320-
dc.contributor.localIdA01654-
dc.contributor.localIdA00074-
dc.contributor.localIdA00703-
dc.contributor.localIdA01151-
dc.contributor.localIdA02110-
dc.contributor.localIdA02526-
dc.contributor.localIdA03486-
dc.contributor.localIdA04043-
dc.contributor.localIdA04272-
dc.contributor.localIdA04304-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid25354265-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameRyu, Geun Woo-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameKang, Ea Wha-
dc.contributor.alternativeNameKim, Yung Ly-
dc.contributor.alternativeNameKim, Hyung Woo-
dc.contributor.alternativeNameShin, Sug Kyun-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameChang, Tae Ik-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorRyu, Geun Woo-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorKang, Ea Wha-
dc.contributor.affiliatedAuthorKim, Yung Ly-
dc.contributor.affiliatedAuthorKim, Hyung Woo-
dc.contributor.affiliatedAuthorShin, Sug Kyun-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorChang, Tae Ik-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorHan, Dae Suk-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.citation.volume9-
dc.citation.number10-
dc.citation.startPagee111373-
dc.identifier.bibliographicCitationPLOS ONE, Vol.9(10) : e111373, 2014-
dc.identifier.rimsid57568-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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