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Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells

Authors
 Takeshi Chiyomaru  ;  Shinichiro Fukuhara  ;  Sharanjot Saini  ;  Shahana Majid  ;  Guoren Deng  ;  Varahram Shahryari  ;  Inik Chang  ;  Yuichiro Tanaka  ;  Hideki Enokida  ;  Masayuki Nakagawa  ;  Rajvir Dahiya  ;  Soichiro Yamamura 
Citation
 Journal of Biological Chemistry, Vol.289(18) : 12550-12565, 2014 
Journal Title
 Journal of Biological Chemistry 
ISSN
 0021-9258 
Issue Date
2014
Abstract
HOTAIR is a long non-coding RNA that interacts with the polycomb repressive complex and suppresses its target genes. HOTAIR has also been demonstrated to promote malignancy. MicroRNA-141 (miR-141) has been reported to play a role in the epithelial to mesenchymal transition process, and the expression of miR-141 is inversely correlated with tumorigenicity and invasiveness in several human cancers. We found that HOTAIR expression is inversely correlated to miR-141 expression in renal carcinoma cells. HOTAIR promotes malignancy, including proliferation and invasion, whereas miR-141 suppresses malignancy in human cancer cells. miR-141 binds to HOTAIR in a sequence-specific manner and suppresses HOTAIR expression and functions, including proliferation and invasion. Both HOTAIR and miR-141 were associated with the immunoprecipitated Ago2 (Argonaute2) complex, and the Ago2 complex cleaved HOTAIR in the presence of miR-141. These results demonstrate that HOTAIR is suppressed by miR-141 in an Ago2-dependent manner.
Full Text
http://www.jbc.org/content/289/18/12550.long
DOI
10.1074/jbc.M113.488593
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
장인익(Chang, In Ik)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100288
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