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Expression of Yes-associated protein (YAP) in breast phyllodes tumor

DC Field Value Language
dc.contributor.author구자승-
dc.contributor.author김상겸-
dc.contributor.author정우희-
dc.date.accessioned2015-01-06T17:35:08Z-
dc.date.available2015-01-06T17:35:08Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100254-
dc.description.abstractThis study aimed to identify expression profiles of Yes-associated protein (YAP) and its phosphorylated form (pYAP) in phyllodes tumor (PT) of human breast and verify the clinical implications. We selected PTs from the pathologic archive and reviewed the histologic features (141 benign, 27 borderline, and 15 malignant). We made tissue microarray (TMA) block from the formalin-fixed paraffin-embedded (FFPE) tissue corresponding to the representative section. Using TMA block, we performed immunohistochemical staining of YAP and pYAP. In the stromal component, expressions of YAP and pYAP were increased in borderline/malignant PT with comparison of benign PT (P = 0.002, and P < 0.001, respectively). In the epithelial component, cytoplasmic expression of YAP was highest in borderline PT (P = 0.001). Stromal YAP expression (P < 0.001) and stromal pYAP expression (P = 0.042) were associated with shorter disease-free survival (DFS) and stromal pYAP expression (P = 0.001) was associated with shorter overall survival (OS) in univariate Cox analysis. In multivariate Cox analysis, stromal YAP expression was an independent prognostic factor associated with shorter DFS (Hazard ration: 3.206, 95% CI: 1.000-10.27, P = 0.050). In conclusion, expression level of YAP in stromal component was increased along with histologic grade of PT and YAP expression in PT was related to tumor progression and poor prognosis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent5997~6005-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdaptor Proteins, Signal Transducing/analysis*-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers, Tumor/analysis-
dc.subject.MESHBreast Neoplasms/chemistry*-
dc.subject.MESHBreast Neoplasms/mortality-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHBreast Neoplasms/therapy-
dc.subject.MESHDisease Progression-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHEpithelial Cells/chemistry-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHPhosphoproteins/analysis*-
dc.subject.MESHPhosphorylation-
dc.subject.MESHPhyllodes Tumor/chemistry*-
dc.subject.MESHPhyllodes Tumor/mortality-
dc.subject.MESHPhyllodes Tumor/pathology-
dc.subject.MESHPhyllodes Tumor/therapy-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHStromal Cells/chemistry-
dc.subject.MESHTime Factors-
dc.subject.MESHTissue Array Analysis-
dc.titleExpression of Yes-associated protein (YAP) in breast phyllodes tumor-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorSang Kyum Kim-
dc.contributor.googleauthorWoo Hee Jung-
dc.contributor.googleauthorJa Seung Koo-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA00520-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ01096-
dc.identifier.eissn1936-2625-
dc.identifier.pmid25337244-
dc.subject.keywordBreast-
dc.subject.keywordYAP-
dc.subject.keywordphyllodes tumor-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Sang Kyum-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Sang Kyum-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume7-
dc.citation.number9-
dc.citation.startPage5997-
dc.citation.endPage6005-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.7(9) : 5997-6005, 2014-
dc.identifier.rimsid51776-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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