Cited 20 times in
Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: another poor prognostic phenotype independent of c-Myc/Bcl2 coexpression
DC Field | Value | Language |
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dc.contributor.author | 양우익 | - |
dc.contributor.author | 윤선옥 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 최성은 | - |
dc.date.accessioned | 2015-01-06T17:33:50Z | - |
dc.date.available | 2015-01-06T17:33:50Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100213 | - |
dc.description.abstract | Deregulation of histone H3 trimethylation at lysine 27 (H3K27me3) via aberration of the histone methyltransferase, enhancer of zeste homologue 2 (EZH2), is suggested to play a critical role in cancers including hematologic malignancies. In the present study, implications of H3K27me3 were investigated in diffuse large B-cell lymphoma (DLBCL) with respect to clinicopathological factors, especially in association with c-Myc/Bcl2 coexpression and germinal center B-like (GCB) or non-GCB subtype. By immunohistochemistry, a high level of H3K27me3 was observed in approximately one-third (35.3%, 79/224) of DLBCL cases, and this subset of cases was related to poor performance status (Eastern Cooperative Oncology Group scores ≥ 2) (P = .013), elevated lactate dehydrogenase level (P = .001), and a higher international prognostic index risk group (scores ≥3) (P = .005). H3K27me3 level was significantly correlated with EZH2 expression (P = .004) and c-Myc protein expression (P = .003) but not correlated with c-Myc/Bcl2 coexpression or with GCB or non-GCB subtype. A high level of H3K27me3 was related to an inferior overall survival (P = .006) and was shown to be an independent prognostic factor for overall survival along with the higher international prognostic index risk group and c-Myc/Bcl2 coexpression. In conclusion, H3K27me3 was related to EZH2 and c-Myc expression, suggesting formation of a MYC-EZH2-H3K27me3 loop in a subgroup of DLBCL cases. H3K27me3 was associated with poor patient outcome and revealed as an independent predictor for overall survival of DLBCL patients. H3K27me3 in DLBCL may be another high-risk phenotype independent of the phenotype of c-Myc/Bcl2 coexpression or other known poor prognostic subgroups. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | HUMAN PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | DNA Methylation/physiology* | - |
dc.subject.MESH | Enhancer of Zeste Homolog 2 Protein | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Histones/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse/genetics | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse/metabolism* | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse/pathology* | - |
dc.subject.MESH | Lysine/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Polycomb Repressive Complex 2/biosynthesis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Proto-Oncogene Proteins c-bcl-2/biosynthesis | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/biosynthesis | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.title | Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: another poor prognostic phenotype independent of c-Myc/Bcl2 coexpression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Eun Ji Oh | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Sung-eun Choi | - |
dc.contributor.googleauthor | Sun Och Yoon | - |
dc.identifier.doi | 10.1016/j.humpath.2014.07.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A02566 | - |
dc.contributor.localId | A03729 | - |
dc.relation.journalcode | J01011 | - |
dc.identifier.eissn | 1532-8392 | - |
dc.identifier.pmid | 25149548 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0046817714002846 | - |
dc.subject.keyword | Bcl2 | - |
dc.subject.keyword | Histone H3 trimethylation at lysine 27 | - |
dc.subject.keyword | Lymphoma, large B-cell, diffuse | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | c-Myc | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Yoon, Sun Och | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Yoon, Sun Och | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 45 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2043 | - |
dc.citation.endPage | 2050 | - |
dc.identifier.bibliographicCitation | HUMAN PATHOLOGY, Vol.45(10) : 2043-2050, 2014 | - |
dc.identifier.rimsid | 51752 | - |
dc.type.rims | ART | - |
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