Cited 22 times in
Effects of chemical castration on sex offenders in relation to the kinetics of serum testosterone recovery: Implications for dosing schedule
DC Field | Value | Language |
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dc.contributor.author | 구교철 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2015-01-06T17:32:04Z | - |
dc.date.available | 2015-01-06T17:32:04Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1743-6095 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100158 | - |
dc.description.abstract | INTRODUCTION: A growing number of countries are adopting chemical castration as treatment and penalty for sex offenders. AIM: The aim of this study is to evaluate the outcome of chemical castration of sexual offenders with a focus on the kinetics of serum testosterone (T) recovery. METHODS: This prospective analysis included 56 sex offenders imprisoned for sexual offenses at the National Forensic Hospital. Thirty-eight and 18 patients who received 3 and 6 months of leuprolide acetate injections were assigned to group A and group B, respectively. MAIN OUTCOME MEASURES: To evaluate treatment efficacy according treatment duration, psychobehavioral assessments and serum T levels were serially measured during the on-cycle and the following observational 12-month off-cycle. RESULTS: Chemical castration and the associated decrease in serum T levels reduced the frequency and intensity of sexual thoughts in 76% and 71% of group A patients and in 78% and 72% of group B patients, respectively. Reductions in masturbation frequency were observed in 74% of group A and 83% of group B patients. The median Wilson's Sex Fantasy Questionnaire (SFQ) scores were also significantly reduced in both groups. In group A, an upsurge of serum T to the flare level was observed during the first 2 months of the off-cycle, accompanied by an intense sexual drive and fantasy. In group B, serum T gradually recovered to the baseline level and continued to upsurge beyond baseline levels during the observational period. SFQ scores of group A returned to pretreatment levels following the observational period; however, SFQ scores of group B remained suppressed. Lack of objective assessments for psychobehavioral outcomes was a limitation. CONCLUSIONS: The efficacy of chemical castration varied according to the treatment duration. Regarding the kinetics of serum T recovery, maintaining at least 6 months of treatment warranted stable control of an excessive sexual drive following treatment cessation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1316~1324 | - |
dc.relation.isPartOf | JOURNAL OF SEXUAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Androgen Antagonists/administration & dosage* | - |
dc.subject.MESH | Androgen Antagonists/pharmacology | - |
dc.subject.MESH | Castration/methods* | - |
dc.subject.MESH | Fantasy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leuprolide/administration & dosage* | - |
dc.subject.MESH | Leuprolide/pharmacology | - |
dc.subject.MESH | Libido/drug effects | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Masturbation/physiopathology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prisoners | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Sex Offenses* | - |
dc.subject.MESH | Sexual Behavior/drug effects | - |
dc.subject.MESH | Surveys and Questionnaires | - |
dc.subject.MESH | Testosterone/metabolism* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Effects of chemical castration on sex offenders in relation to the kinetics of serum testosterone recovery: Implications for dosing schedule | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Jin Hyoung Ahn | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Jae Woo Lee | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.identifier.doi | 10.1111/jsm.12492 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J01747 | - |
dc.identifier.eissn | 1743-6109 | - |
dc.identifier.pmid | 24571582 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/jsm.12492/abstract | - |
dc.subject.keyword | Behavior | - |
dc.subject.keyword | Castration | - |
dc.subject.keyword | Paraphilia | - |
dc.subject.keyword | Sex Offender | - |
dc.subject.keyword | Testosterone | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1316 | - |
dc.citation.endPage | 1324 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SEXUAL MEDICINE, Vol.11(5) : 1316-1324, 2014 | - |
dc.identifier.rimsid | 51715 | - |
dc.type.rims | ART | - |
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