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Low body mass index is associated with adverse oncological outcomes following radical prostatectomy in Korean prostate cancer patients

DC FieldValueLanguage
dc.contributor.author구교철-
dc.contributor.author나군호-
dc.contributor.author양승철-
dc.contributor.author윤영은-
dc.contributor.author정병하-
dc.contributor.author홍성준-
dc.date.accessioned2015-01-06T17:32:02Z-
dc.date.available2015-01-06T17:32:02Z-
dc.date.issued2014-
dc.identifier.issn0301-1623-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100157-
dc.description.abstractPURPOSE: The purpose of this study was to determine the impact of obesity on clinicopathological features and biochemical recurrence (BCR) following radical prostatectomy (RP) in Korean prostate cancer (PCa) patients. METHODS: A single-institutional retrospective analysis was performed on 880 PCa patients treated by RP without neoadjuvant therapy between July 2005 and December 2011. Patients were stratified according to body mass index (BMI) standards for Asian populations: obese (BMI ≥25 kg/m(2)), overweight (BMI 23-24.9 kg/m(2)), or normal weight (BMI <23 kg/m(2)). For analysis, overweight and obese patients were combined (n = 592, BMI ≥23 kg/m(2)) and compared with normal weight patients (n = 288, BMI <23 kg/m(2)). BCR was defined as prostate-specific antigen (PSA) ≥0.2 ng/ml following RP. RESULTS: Normal weight patients tended to be classified into the higher D'Amico risk category with smaller prostate volumes compared with obese and overweight patients. Normal weight patients had higher pathological Gleason scores and were at higher risk of BCR during the mean follow-up of 58.2 months. This translated to a higher 5-year BCR-free survival rate for obese and overweight patients compared with normal weight patients (77.8 vs. 70.3 %; p = 0.017). On multiple Cox-proportional hazards regression analysis incorporating variables of BMI category, PSA, positive surgical margins, pathological T stage, and Gleason score, higher BMI category remained a significant predictor of a lower risk of BCR (HR = 0.634, p = 0.028). CONCLUSIONS: Obese and overweight Korean PCa patients have lower Gleason scores and a reduced risk of BCR compared with normal weight patients. These findings suggest that body fat influences pathological features and oncologic outcomes of PCa.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1935~1940-
dc.relation.isPartOfINTERNATIONAL UROLOGY AND NEPHROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBody Mass Index*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHObesity/complications-
dc.subject.MESHOverweight/complications-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHProstatectomy*-
dc.subject.MESHProstatic Neoplasms/pathology*-
dc.subject.MESHProstatic Neoplasms/surgery*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.titleLow body mass index is associated with adverse oncological outcomes following radical prostatectomy in Korean prostate cancer patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorKyo Chul Koo-
dc.contributor.googleauthorYoung Eun Yoon-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorByung Ha Chung-
dc.contributor.googleauthorSeung Choul Yang-
dc.contributor.googleauthorSung Joon Hong-
dc.identifier.doi10.1007/s11255-014-0729-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00188-
dc.contributor.localIdA01227-
dc.contributor.localIdA02294-
dc.contributor.localIdA02581-
dc.contributor.localIdA03607-
dc.contributor.localIdA04402-
dc.relation.journalcodeJ01177-
dc.identifier.eissn1573-2584-
dc.identifier.pmid24817520-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs11255-014-0729-7-
dc.subject.keywordBody mass index-
dc.subject.keywordObesity-
dc.subject.keywordProstate cancer-
dc.subject.keywordProstatectomy-
dc.subject.keywordTreatment outcome-
dc.contributor.alternativeNameKoo, Kyo Chul-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.alternativeNameYang, Seung Choul-
dc.contributor.alternativeNameYoon, Young Eun-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.alternativeNameHong, Sung Joon-
dc.contributor.affiliatedAuthorKoo, Kyo Chul-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.contributor.affiliatedAuthorYang, Seung Choul-
dc.contributor.affiliatedAuthorYoon, Young Eun-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.contributor.affiliatedAuthorHong, Sung Joon-
dc.rights.accessRightsfree-
dc.citation.volume46-
dc.citation.number10-
dc.citation.startPage1935-
dc.citation.endPage1940-
dc.identifier.bibliographicCitationINTERNATIONAL UROLOGY AND NEPHROLOGY, Vol.46(10) : 1935-1940, 2014-
dc.identifier.rimsid51714-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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