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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes

DC Field Value Language
dc.contributor.author김민경-
dc.contributor.author전부남-
dc.contributor.author최원일-
dc.contributor.author허만욱-
dc.date.accessioned2015-01-06T17:31:08Z-
dc.date.available2015-01-06T17:31:08Z-
dc.date.issued2014-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100129-
dc.description.abstractAn unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. In this study, we show that KAISO is induced by DNA damage in p53-expressing cells and then interacts with the p53–p300 complex to increase acetylation of p53 K320 and K382 residues, although decreasing K381 acetylation. Moreover, the p53 with this particular acetylation pattern shows increased DNA binding and potently induces cell cycle arrest and apoptosis by activating transcription of CDKN1A (cyclin-dependent kinase inhibitor 1) and various apoptotic genes. Analogously, in Kaiso KO mouse embryonic fibroblast cells, p53-to-promoter binding and up-regulation of p21 and apoptosis gene expression is significantly compromised. KAISO may therefore be a critical regulator of p53-mediated cell cycle arrest and apoptosis in response to various genotoxic stresses in mammalian cells.-
dc.description.statementOfResponsibilityopen-
dc.format.extent15078~15083-
dc.relation.isPartOfPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcetylation-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis*-
dc.subject.MESHCell Cycle-
dc.subject.MESHCell Line-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p21/metabolism*-
dc.subject.MESHDNA/chemistry-
dc.subject.MESHDNA Damage-
dc.subject.MESHDNA Methylation-
dc.subject.MESHE1A-Associated p300 Protein/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHFibroblasts/cytology-
dc.subject.MESHHCT116 Cells-
dc.subject.MESHHEK293 Cells-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHProtein Binding-
dc.subject.MESHResponse Elements-
dc.subject.MESHTranscription Factors/metabolism*-
dc.subject.MESHTumor Suppressor Protein p53/metabolism*-
dc.titleKAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorDong-In Koh-
dc.contributor.googleauthorDohyun Han-
dc.contributor.googleauthorHoon Ryu-
dc.contributor.googleauthorWon-Il Choi-
dc.contributor.googleauthorBu-Nam Jeon-
dc.contributor.googleauthorMin-Kyeong Kim-
dc.contributor.googleauthorYoungsoo Kim-
dc.contributor.googleauthorJin Young Kim-
dc.contributor.googleauthorLee Parry-
dc.contributor.googleauthorAlan R. Clarke-
dc.contributor.googleauthorAlbert B. Reynolds-
dc.contributor.googleauthorMan-Wook Hur-
dc.identifier.doi10.1073/pnas.1318780111-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00456-
dc.contributor.localIdA03517-
dc.contributor.localIdA04126-
dc.contributor.localIdA04350-
dc.relation.journalcodeJ02550-
dc.identifier.eissn1091-6490-
dc.identifier.pmid25288747-
dc.identifier.urlhttp://www.pnas.org/content/111/42/15078.long-
dc.subject.keywordKAISO-
dc.subject.keywordapoptosis-
dc.subject.keywordcell cycle arrest-
dc.subject.keywordp300-
dc.subject.keywordp53-
dc.contributor.alternativeNameKim, Min Kyeong-
dc.contributor.alternativeNameJeon, Bu Nam-
dc.contributor.alternativeNameChoi, Won Il-
dc.contributor.alternativeNameHur, Man Wook-
dc.contributor.affiliatedAuthorKim, Min Kyeong-
dc.contributor.affiliatedAuthorJeon, Bu Nam-
dc.contributor.affiliatedAuthorChoi, Won Il-
dc.contributor.affiliatedAuthorHur, Man Wook-
dc.rights.accessRightsfree-
dc.citation.volume111-
dc.citation.number42-
dc.citation.startPage15078-
dc.citation.endPage15083-
dc.identifier.bibliographicCitationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.111(42) : 15078-15083, 2014-
dc.identifier.rimsid50529-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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