Cited 45 times in
KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김민경 | - |
dc.contributor.author | 전부남 | - |
dc.contributor.author | 최원일 | - |
dc.contributor.author | 허만욱 | - |
dc.date.accessioned | 2015-01-06T17:31:08Z | - |
dc.date.available | 2015-01-06T17:31:08Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100129 | - |
dc.description.abstract | An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. In this study, we show that KAISO is induced by DNA damage in p53-expressing cells and then interacts with the p53–p300 complex to increase acetylation of p53 K320 and K382 residues, although decreasing K381 acetylation. Moreover, the p53 with this particular acetylation pattern shows increased DNA binding and potently induces cell cycle arrest and apoptosis by activating transcription of CDKN1A (cyclin-dependent kinase inhibitor 1) and various apoptotic genes. Analogously, in Kaiso KO mouse embryonic fibroblast cells, p53-to-promoter binding and up-regulation of p21 and apoptosis gene expression is significantly compromised. KAISO may therefore be a critical regulator of p53-mediated cell cycle arrest and apoptosis in response to various genotoxic stresses in mammalian cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 15078~15083 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetylation | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis* | - |
dc.subject.MESH | Cell Cycle | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p21/metabolism* | - |
dc.subject.MESH | DNA/chemistry | - |
dc.subject.MESH | DNA Damage | - |
dc.subject.MESH | DNA Methylation | - |
dc.subject.MESH | E1A-Associated p300 Protein/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblasts/cytology | - |
dc.subject.MESH | HCT116 Cells | - |
dc.subject.MESH | HEK293 Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Response Elements | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.subject.MESH | Tumor Suppressor Protein p53/metabolism* | - |
dc.title | KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Dong-In Koh | - |
dc.contributor.googleauthor | Dohyun Han | - |
dc.contributor.googleauthor | Hoon Ryu | - |
dc.contributor.googleauthor | Won-Il Choi | - |
dc.contributor.googleauthor | Bu-Nam Jeon | - |
dc.contributor.googleauthor | Min-Kyeong Kim | - |
dc.contributor.googleauthor | Youngsoo Kim | - |
dc.contributor.googleauthor | Jin Young Kim | - |
dc.contributor.googleauthor | Lee Parry | - |
dc.contributor.googleauthor | Alan R. Clarke | - |
dc.contributor.googleauthor | Albert B. Reynolds | - |
dc.contributor.googleauthor | Man-Wook Hur | - |
dc.identifier.doi | 10.1073/pnas.1318780111 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00456 | - |
dc.contributor.localId | A03517 | - |
dc.contributor.localId | A04126 | - |
dc.contributor.localId | A04350 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 25288747 | - |
dc.identifier.url | http://www.pnas.org/content/111/42/15078.long | - |
dc.subject.keyword | KAISO | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | cell cycle arrest | - |
dc.subject.keyword | p300 | - |
dc.subject.keyword | p53 | - |
dc.contributor.alternativeName | Kim, Min Kyeong | - |
dc.contributor.alternativeName | Jeon, Bu Nam | - |
dc.contributor.alternativeName | Choi, Won Il | - |
dc.contributor.alternativeName | Hur, Man Wook | - |
dc.contributor.affiliatedAuthor | Kim, Min Kyeong | - |
dc.contributor.affiliatedAuthor | Jeon, Bu Nam | - |
dc.contributor.affiliatedAuthor | Choi, Won Il | - |
dc.contributor.affiliatedAuthor | Hur, Man Wook | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 111 | - |
dc.citation.number | 42 | - |
dc.citation.startPage | 15078 | - |
dc.citation.endPage | 15083 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.111(42) : 15078-15083, 2014 | - |
dc.identifier.rimsid | 50529 | - |
dc.type.rims | ART | - |
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