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Late Gadolinium Enhancement in Cardiac MRI in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Systolic Function Is Related to Attenuated Improvement of Left Ventricular Geometry and Filling Pressure after Aortic Valve Replacement

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dc.contributor.author박준범-
dc.contributor.author신상훈-
dc.contributor.author심지영-
dc.contributor.author양필성-
dc.contributor.author이상은-
dc.contributor.author장혁재-
dc.contributor.author정남식-
dc.contributor.author조인정-
dc.contributor.author최정호-
dc.contributor.author허란-
dc.contributor.author홍그루-
dc.contributor.author김영진-
dc.date.accessioned2015-01-06T17:30:16Z-
dc.date.available2015-01-06T17:30:16Z-
dc.date.issued2014-
dc.identifier.issn1738-5520-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100102-
dc.description.abstractBACKGROUND AND OBJECTIVES: WE INVESTIGATED ECHOCARDIOGRAPHIC PREDICTORS: left ventricular (LV) geometric changes following aortic valve replacement (AVR) according to the late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) in patients with severe aortic stenosis (AS) and preserved LV systolic function. SUBJECTS AND METHODS: We analyzed 41 patients (24 males, 63.1±8.7 years) with preserved LV systolic function who were scheduled to undergo AVR for severe AS. All patients were examined with transthoracic echocardiography (TTE), CMR before and after AVR (in the hospital) and serial TTEs (at 6 and 12 months) were repeated. RESULTS: The group with LGE (LGE+) showed greater wall thickness (septum, 14.3±2.6 mm vs. 11.5±2.0 mm, p=0.001, posterior; 14.3±2.5 mm vs. 11.4±1.6 mm, p<0.001), lower tissue Doppler image (TDIS', 4.4±1.4 cm/s vs. 5.5±1.2 cm/s, p=0.021; TDI E', 3.2±0.9 cm/s vs. 4.8±1.4 cm/s, p=0.002), and greater E/e' (21.8±10.3 vs. 15.4±6.3, p=0.066) than those without LGE (LGE-). Multivariate analysis show that TDI e' (odds ratio=0.078, 95% confidence interval=0.007-0.888, p=0.040) was an independent determinant of LGE+. In an analysis of the 6- and 12-month follow-up compared with pre-AVR, LGE- showed decreased LV end-diastolic diameter (48.3±5.0 mm vs. 45.8±3.6 mm, p=0.027; 48.3±5.0 mm vs. 46.5±3.4 mm, p=0.019). Moreover, E/e' (at 12 months) showed further improved LV filling pressure (16.0±6.6 vs. 12.3±4.3, p=0.001) compared with pre-AVR. However, LGE+ showed no significant improvement. CONCLUSION: The absence of LGE is associated with favorable improvements in LV geometry and filling pressure. TDI E' is an independent determinant of LGE in patients with severe AS and preserved LV systolic function.-
dc.description.statementOfResponsibilityopen-
dc.format.extent312~319-
dc.relation.isPartOfKorean Circulation Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLate Gadolinium Enhancement in Cardiac MRI in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Systolic Function Is Related to Attenuated Improvement of Left Ventricular Geometry and Filling Pressure after Aortic Valve Replacement-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJunbeom Park-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorJung-Ho Choi-
dc.contributor.googleauthorPil-Sung Yang-
dc.contributor.googleauthorSang-Eun Lee-
dc.contributor.googleauthorRan Heo-
dc.contributor.googleauthorSanghoon Shin-
dc.contributor.googleauthorIn-Jeong Cho-
dc.contributor.googleauthorYoung-Jin Kim-
dc.contributor.googleauthorChi Young Shim-
dc.contributor.googleauthorGeu-Ru Hong-
dc.contributor.googleauthorNamsik Chung-
dc.identifier.doi10.4070/kcj.2014.44.5.312-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01670-
dc.contributor.localIdA02107-
dc.contributor.localIdA02213-
dc.contributor.localIdA02323-
dc.contributor.localIdA03490-
dc.contributor.localIdA03585-
dc.contributor.localIdA03892-
dc.contributor.localIdA04180-
dc.contributor.localIdA04348-
dc.contributor.localIdA04386-
dc.contributor.localIdA02827-
dc.contributor.localIdA00727-
dc.relation.journalcodeJ01952-
dc.contributor.alternativeNamePark, Jun Beom-
dc.contributor.alternativeNameShin, Sang Hoon-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameYang, Pil Sung-
dc.contributor.alternativeNameLee, Sang Eun-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameCho, In Jeong-
dc.contributor.alternativeNameChoi, Jung Ho-
dc.contributor.alternativeNameHeo, Ran-
dc.contributor.alternativeNameHong, Geu Ru-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.affiliatedAuthorPark, Jun Beom-
dc.contributor.affiliatedAuthorShin, Sang Hoon-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorYang, Pil Sung-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorCho, In Jeong-
dc.contributor.affiliatedAuthorChoi, Jung Ho-
dc.contributor.affiliatedAuthorHeo, Ran-
dc.contributor.affiliatedAuthorHong, Geu Ru-
dc.contributor.affiliatedAuthorLee, Sang Eun-
dc.contributor.affiliatedAuthorKim, Young Jin-
dc.citation.volume44-
dc.citation.number05-
dc.citation.startPage312-
dc.citation.endPage319-
dc.identifier.bibliographicCitationKorean Circulation Journal, Vol.44(05) : 312-319, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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