Cited 39 times in
Clinical significance of Ki-67 and p53 expression in curatively resected non-small cell lung cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정민규 | - |
dc.date.accessioned | 2015-01-06T17:30:05Z | - |
dc.date.available | 2015-01-06T17:30:05Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100097 | - |
dc.description.abstract | The aim of this study is to explore the association of Ki-67 and p53 expression with prognosis in non-small cell lung cancer (NSCLC) patients who underwent curative resection. We retrospectively identified 116 consecutive patients with stages I–III NSCLC who underwent curative resection at a single center from January 2007 to December 2012. Ki-67 and p53 expression was assessed by immunohistochemistry. Data on clinicopathologic features and survival were collected retrospectively. Ki-67 expression in 109 samples and p53 expression in 115 patients were analyzed. According to the results, 108 patients (99 %) showed at least some expression of Ki-67. The median Ki-67 expression level was 30 %. Positive p53 expression was observed in 91 (79 %) patients. Higher Ki-67 expression (>40 %) was significantly more frequent in male (26 vs. 4 % in female, p = 0.002), ever-smoker (31 vs. 10 % in never-smoker, p = 0.024), and non-adenocarcinoma (30 vs. 11 % of adenocarcinoma, p = 0.012) patients. In univariable analysis, median disease-free survival (DFS) was shorter with higher Ki-67 expression (16.1 vs. 61.9 months in those with lower Ki-67 expression, p = 0.005), and p53 expression did not show an association with DFS. Among 42 patients with stage I NSCLC who did not receive adjuvant chemotherapy, DFS was significantly worse in patients with higher Ki-67 expression (2-year DFS rate 57 vs. 88 %, p = 0.018). In a Cox regression model, higher Ki-67 expression (>40 %) was a significant independent prognostic factor associated with poorer DFS (HR 2.9, 95 % CI 1.3–6.2) along with TNM stage and age. Higher Ki-67 expression (>40 %) showed an independent association with shorter DFS in NSCLC patients who underwent curative resection. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 5735~5740 | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/chemistry | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/mortality | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/pathology* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ki-67 Antigen/analysis* | - |
dc.subject.MESH | Lung Neoplasms/chemistry | - |
dc.subject.MESH | Lung Neoplasms/mortality | - |
dc.subject.MESH | Lung Neoplasms/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tumor Suppressor Protein p53/analysis* | - |
dc.title | Clinical significance of Ki-67 and p53 expression in curatively resected non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hee Kyung Ahn | - |
dc.contributor.googleauthor | Minkyu Jung | - |
dc.contributor.googleauthor | Seung-Yeon Ha | - |
dc.contributor.googleauthor | Jae-Ik Lee | - |
dc.contributor.googleauthor | Inkeun Park | - |
dc.contributor.googleauthor | Young Saing Kim | - |
dc.contributor.googleauthor | Junshik Hong | - |
dc.contributor.googleauthor | Sun Jin Sym | - |
dc.contributor.googleauthor | Jinny Park | - |
dc.contributor.googleauthor | Dong Bok Shin | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Eun Kyung Cho | - |
dc.identifier.doi | 10.1007/s13277-014-1760-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03606 | - |
dc.relation.journalcode | J02763 | - |
dc.identifier.eissn | 1423-0380 | - |
dc.identifier.pmid | 24737581 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs13277-014-1760-0 | - |
dc.subject.keyword | Non-small cell lung carcinoma | - |
dc.subject.keyword | Ki-67 | - |
dc.subject.keyword | p53 | - |
dc.subject.keyword | Immunostaining | - |
dc.subject.keyword | Resection | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Jung, Min Kyu | - |
dc.contributor.affiliatedAuthor | Jung, Min Kyu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 5735 | - |
dc.citation.endPage | 5740 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, Vol.35(6) : 5735-5740, 2014 | - |
dc.identifier.rimsid | 50137 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.