Cited 6 times in
Increased Dialysate MCP-1 is Associated with Cardiovascular Mortality in Peritoneal Dialysis Patients: A Prospective Observational Study
DC Field | Value | Language |
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dc.contributor.author | 유태현 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 고광일 | - |
dc.contributor.author | 구향모 | - |
dc.contributor.author | 김찬호 | - |
dc.contributor.author | 도화미 | - |
dc.contributor.author | 박경숙 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 오형중 | - |
dc.date.accessioned | 2015-01-06T17:29:58Z | - |
dc.date.available | 2015-01-06T17:29:58Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0250-8095 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100093 | - |
dc.description.abstract | Background: The aim of this study was to investigate the association between the dialysate MCP-1 (dMCP-1) and systemic inflammatory and nutritional markers in peritoneal dialysis (PD) patients. In addition, we examined the prognostic value of dMCP-1 on all-cause or cardiovascular mortality in these patients. Methods: We prospectively followed 169 prevalent PD patients from April 1st 2008 to December 31st 2012. At baseline, dMCP-1 and serum biochemical parameters including high sensitivity CRP (hs-CRP) and albumin were checked. All-cause mortality and cause of death were evaluated during the follow-up period. Based on the median level of dMCP-1, patients were classified as either low or high dMCP-1 groups. Results: Mean age, hs-CRP, and D/Pcr ratio at 4 h were significantly higher, while serum albumin levels and %lean body mass (LBM) were significantly lower in the high dMCP-1 group. During the mean follow-up period of 47.7 months, all-cause mortality and cardiovascular mortality rate were significantly higher in the high dMCP-1 group (9.6 and 6.3 per 100 person-years, respectively) compared to the low dMCP-1 group (5.1 and 3.1 per 100 person-years, respectively; p = 0.021, 0.038). In multivariate Cox analysis, high dMCP-1 was a significant independent predictor of all-cause mortality (hazard ratio: 1.83, 95% confidence interval: 1.03-3.24, p = 0.039). Conclusions: dMCP-1 levels are closely correlated with nutritional and systemic inflammatory markers in PD patients. In addition, increased dMCP-1 is significantly associated with higher all-cause and cardiovascular mortality. These findings suggest that local peritoneal inflammation could contribute to poor clinical outcomes in PD patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 291~299 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cardiovascular Diseases/complications | - |
dc.subject.MESH | Cardiovascular Diseases/metabolism* | - |
dc.subject.MESH | Cardiovascular Diseases/mortality | - |
dc.subject.MESH | Chemokine CCL2/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Failure, Chronic/complications | - |
dc.subject.MESH | Kidney Failure, Chronic/metabolism* | - |
dc.subject.MESH | Kidney Failure, Chronic/mortality | - |
dc.subject.MESH | Kidney Failure, Chronic/therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Peritoneal Dialysis, Continuous Ambulatory | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.title | Increased Dialysate MCP-1 is Associated with Cardiovascular Mortality in Peritoneal Dialysis Patients: A Prospective Observational Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ko K.I. | - |
dc.contributor.googleauthor | Park K.S. | - |
dc.contributor.googleauthor | Lee M.J. | - |
dc.contributor.googleauthor | Doh F.M. | - |
dc.contributor.googleauthor | Kim C.H. | - |
dc.contributor.googleauthor | Koo H.M. | - |
dc.contributor.googleauthor | Oh H.J. | - |
dc.contributor.googleauthor | Park J.T. | - |
dc.contributor.googleauthor | Han S.H. | - |
dc.contributor.googleauthor | Kang S.-W. | - |
dc.contributor.googleauthor | Yoo T.-H. | - |
dc.identifier.doi | 10.1159/000368201 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00110 | - |
dc.contributor.localId | A00203 | - |
dc.contributor.localId | A01037 | - |
dc.contributor.localId | A01315 | - |
dc.contributor.localId | A01423 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02417 | - |
dc.contributor.localId | A02773 | - |
dc.relation.journalcode | J00094 | - |
dc.identifier.eissn | 1421-9670 | - |
dc.identifier.pmid | 25323428 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/368201 | - |
dc.subject.keyword | Dialysate MCP-1 | - |
dc.subject.keyword | hs-CRP | - |
dc.subject.keyword | Peritoneal dialysis | - |
dc.subject.keyword | Cardiovascular mortality | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Ko, Kwang Il | - |
dc.contributor.alternativeName | Koo, Hyang Mo | - |
dc.contributor.alternativeName | Kim, Chan Ho | - |
dc.contributor.alternativeName | Doh, Fa Mee | - |
dc.contributor.alternativeName | Park, Kyoung Sook | - |
dc.contributor.alternativeName | Park, Jung Tak | - |
dc.contributor.alternativeName | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Ko, Kwang Il | - |
dc.contributor.affiliatedAuthor | Koo, Hyang Mo | - |
dc.contributor.affiliatedAuthor | Kim, Chan Ho | - |
dc.contributor.affiliatedAuthor | Doh, Fa Mee | - |
dc.contributor.affiliatedAuthor | Park, Kyoung Sook | - |
dc.contributor.affiliatedAuthor | Park, Jung Tak | - |
dc.contributor.affiliatedAuthor | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 291 | - |
dc.citation.endPage | 299 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF NEPHROLOGY, Vol.40(4) : 291-299, 2014 | - |
dc.identifier.rimsid | 50135 | - |
dc.type.rims | ART | - |
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