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Morphological parameters related to ruptured aneurysm in the patient with multiple cerebral aneurysms (clinical investigation)

 Hong Jun Jeon  ;  Jae Whan Lee  ;  So Yeon Kim  ;  Keun Young Park  ;  Seung Kon Huh 
 Neurological Research, Vol.36(12) : 1056-1052, 2014 
Journal Title
 Neurological Research 
Issue Date
OBJECTIVES: We evaluated the rupture risk of multiple cerebral aneurysms in aspects of various morphological parameters, and determined which parameter can be a reliable predictor as one aneurysm ruptured, and the others did not. METHODS: Between 2007 and 2012, three-dimensional (3D) angiographic images of 85 patients harboring multiple aneurysms (85 ruptured and 104 unruptured aneurysms) were used to assess the following morphological parameters: geometry of the aneurysm itself, e.g., maximal size, aspect ratio, bottleneck ratio, height/width ratio, undulation, and daughter sac; architecture of the aneurysm and surrounding vessels, e.g. aneurysmal angle, vessel angle, inflow angle, parent-daughter angle, and size ratio type I & II. Univariate analysis was applied to all parameters, and significant parameters were identified in multivariate analysis, yielding the cut-off point from receiver-operating characteristic (ROC) curve analysis. RESULTS: On multivariate logistic regression, the aspect ratio [odds ratio (OR), 1.21; 95% confidence interval (CI), 1.05-1.41] and daughter sac (OR, 3.12; 95% CI, 1.05-9.27) were significant parameters in geometries of the aneurysm itself. The size ratio type I (OR, 1.14; 95% CI, 1.05-1.22) and parent-daughter angle (OR, 1.02; 95% CI, 1.00-1.04) were independent parameters in architecture of the aneurysm and surrounding vessels. From the ROC curve, the aspect ratio and size ratio type I had cut-off values of 1.3 and 1.8, respectively. CONCLUSION: Several morphological parameters were investigated to predict a rupture in multiple cerebral aneurysms using 3D angiogram. The aspect ratio, size ratio type I, daughter sac, and parent-daughter angle were revealed as competent parameters.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김소연(Kim, So Yeon)
박근영(Park, Keun Young)
이재환(Lee, Jae Whan)
전홍준(Jeon, Hong Jun)
허승곤(Huh, Seung Kon)
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