Cited 23 times in
Atypical teratoid/rhabdoid tumor arising in pleomorphic xanthoastrocytoma
DC Field | Value | Language |
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dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2015-01-06T17:27:51Z | - |
dc.date.available | 2015-01-06T17:27:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0919-6544 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100027 | - |
dc.description.abstract | Atypical teratoid/rhabdoid tumor (AT/RT) is a rare, highly malignant, true rhabdoid tumor in the central nervous system predominantly presenting in young children. AT/RT typically shows rhabdoid cells which can also be seen in other tumors, but it is differentiated from other tumors by the specific genetic alteration involving the SMARCB1 gene. Only a few cases of AT/RT arising in low-grade glioma have been reported. A 13-year-old girl presented with headache, dizziness, nausea and vomiting. A 4.7 cm cerebellar mass was found on MRI. The mass was totally removed. Histologically, the tumor revealed two distinct morphologic appearances: central areas of AT/RT containing rhabdoid cells and sarcomatous component in the background of pleomorphic xanthoastrocytoma (PXA). Immunohistochemically, PXA areas retained nuclear expression of INI-1 and low Ki-67 proliferation index, whereas AT/RT component showed loss of INI-1 nuclear expression and markedly elevated Ki-67 proliferation index. Epithelial membrane antigen (EMA), smooth muscle actin (SMA), and p53 protein were positive only in AT/RT. BRAF V600E mutation was identified in PXA by real-time polymerase chain reaction. We report a rare case of AT/RT arising in PXA which is supposed to progress by inactivation of INI-1 in a pre-existing PXA. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 398~405 | - |
dc.relation.isPartOf | NEUROPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Astrocytoma/ultrastructure* | - |
dc.subject.MESH | Cerebellar Neoplasms/ultrastructure* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Rhabdoid Tumor/ultrastructure* | - |
dc.subject.MESH | Teratoma/ultrastructure* | - |
dc.title | Atypical teratoid/rhabdoid tumor arising in pleomorphic xanthoastrocytoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Ji Yun Jeong | - |
dc.contributor.googleauthor | Yeon-Lim Suh | - |
dc.contributor.googleauthor | SoonWon Hong | - |
dc.identifier.doi | 10.1111/neup.12106 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J02348 | - |
dc.identifier.eissn | 1440-1789 | - |
dc.identifier.pmid | 25268025 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/neup.12106/abstract | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 398 | - |
dc.citation.endPage | 405 | - |
dc.identifier.bibliographicCitation | NEUROPATHOLOGY, Vol.34(4) : 398-405, 2014 | - |
dc.identifier.rimsid | 55093 | - |
dc.type.rims | ART | - |
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