Cited 8 times in
Effect of High-Dose Statin Loading on Biomarkers Related to Inflammation and Renal Injury in Patients Hospitalized With Acute Heart Failure
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강석민 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 오재원 | - |
dc.contributor.author | 윤종찬 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍남기 | - |
dc.date.accessioned | 2015-01-06T17:27:39Z | - |
dc.date.available | 2015-01-06T17:27:39Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100021 | - |
dc.description.abstract | Background:High-dose statin loading is known to reduce periprocedural myocardial infarction and contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention. However, the clinical role of high-dose statin loading in patients with acute heart failure (AHF) remains unknown.Methods and Results:In a prospective, single-center, randomized, controlled, open-label pilot study, patients hospitalized with AHF were randomly assigned to receive oral high-dose atorvastatin loading (80 mg for 3 days, followed by 10 mg/day until discharge) or no statin therapy, on top of optimal HF treatment. The primary outcome measures were changes to the level of biomarkers related to inflammation and renal injury from admission to hospital day 4. No significant changes in the levels of NT-proBNP (−2,627±4,956 vs. −2,981±6,951 pg/ml, P=0.845), hsCRP (−6.1±16.4 vs. −2.1±16.2 mg/L, P=0.105), cystatin C (0.002±0.185 vs. 0.009±0.216 mg/L, P=0.904), ACR (−886.3±1,984.9 vs. −165.6±825.2 mg/day, P=0.124) were observed in either group. In-hospital mortality (4.3% vs. 3.8%, P>0.999) and all-cause mortality at 90 days (4.3% vs. 3.8%, P>0.999) were not significantly different between groups.Conclusions:This pilot study showed that oral high-dose atorvastatin loading may be used safely in patients with AHF, but is not effective in reducing the levels of circulating biomarkers related to inflammation and renal injury during hospitalization. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2447~2454 | - |
dc.relation.isPartOf | CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Kidney Injury*/blood | - |
dc.subject.MESH | Acute Kidney Injury*/mortality | - |
dc.subject.MESH | Administration, Oral | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Atorvastatin Calcium | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Failure*/blood | - |
dc.subject.MESH | Heart Failure*/complications | - |
dc.subject.MESH | Heart Failure*/drug therapy | - |
dc.subject.MESH | Heart Failure*/mortality | - |
dc.subject.MESH | Heptanoic Acids/administration & dosage* | - |
dc.subject.MESH | Heptanoic Acids/adverse effects | - |
dc.subject.MESH | Hospital Mortality | - |
dc.subject.MESH | Hospitalization* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage* | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Natriuretic Peptide, Brain/blood* | - |
dc.subject.MESH | Peptide Fragments/blood* | - |
dc.subject.MESH | Pilot Projects | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Pyrroles/administration & dosage* | - |
dc.subject.MESH | Pyrroles/adverse effects | - |
dc.title | Effect of High-Dose Statin Loading on Biomarkers Related to Inflammation and Renal Injury in Patients Hospitalized With Acute Heart Failure | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Jong-Chan Youn | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.identifier.doi | 10.1253/circj.CJ-14-0670 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02600 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04388 | - |
dc.contributor.localId | A02395 | - |
dc.contributor.localId | A02833 | - |
dc.relation.journalcode | J00534 | - |
dc.identifier.eissn | 1347-4820 | - |
dc.identifier.pmid | 25168278 | - |
dc.subject.keyword | Acute decompensated heart failure | - |
dc.subject.keyword | Biomarkers | - |
dc.subject.keyword | Statins | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Oh, Jae Won | - |
dc.contributor.alternativeName | Youn, Jong Chan | - |
dc.contributor.alternativeName | Lee, Sang Hak | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Nam Ki | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Youn, Jong Chan | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Namki | - |
dc.contributor.affiliatedAuthor | Oh, Jae Won | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.citation.volume | 78 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2447 | - |
dc.citation.endPage | 2454 | - |
dc.identifier.bibliographicCitation | CIRCULATION JOURNAL, Vol.78(10) : 2447-2454, 2014 | - |
dc.identifier.rimsid | 55089 | - |
dc.type.rims | ART | - |
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