https://ir.ymlib.yonsei.ac.kr/handle/22282913/205270 Mon, 04 May 2026 08:40:29 GMT 2026-05-04T08:40:29Z https://ir.ymlib.yonsei.ac.kr/handle/22282913/211902 Title: Global burden of disease due to young-onset dementia and the forecast for 2050: update from global burden of disease study 2021 Authors: Park, Yoonseo; Jeong, Heejae; Kim, Eun-Ji; Park, Sewon; Lee, Munjae; Jakovljevic, Mihajlo; 이문재 Abstract: ObjectiveThe prevalence of young-onset dementia (YOD) is increasing worldwide, leading to greater economic and social burden, necessitating strategic management and prevention.Materials and methodsUsing GBD 2021 data, disability-adjusted life years (DALYs) rates were analyzed by age, sex, and risk factors across five age groups. ARIMA and Bayesian models were applied to predict disease burden through 2050.ResultsFrom 1990 to 2021, disease burden increased in both sexes aged >= 55 years, with the greatest rise in the 55-59 group. DALYs rates were consistently higher in females, peaking in the 60-64 group. High fasting plasma glucose was the leading risk factor. Model performance varied by sex and age; applying the best-fitting models indicated a continued increase in burden, particularly among females.ConclusionsYOD burden has risen over time and is associated with modifiable factors such as high blood glucose and body mass index. The increasing trend is expected to persist, highlighting the need for effective management strategies to reduce future socioeconomic impact. Tue, 01 Dec 2026 00:00:00 GMT https://ir.ymlib.yonsei.ac.kr/handle/22282913/211902 2026-12-01T00:00:00Z https://ir.ymlib.yonsei.ac.kr/handle/22282913/211946 Title: Intergenerational coresidence and parental depression: A discrete-time survival analysis of the 'boomerang kids' phenomenon Authors: Choi, Seoyeong; Choi, Eunjeong; Jang, Suk-Yong; 장석용 Abstract: Objective: The return of adult children to the parental home-a phenomenon often referred to as "boomerang kids"-has become more prevalent amid economic instability. While widely observed, limited evidence exists on its impact on parental mental health, particularly in the East Asian context. Methods: We used longitudinal data from the Korean Welfare Panel Study (KoWePS), identifying 2479 adult children and their 4659 co-residing parents. The primary exposure was the return of adult children, defined by changes in co-residence. Discrete-time survival analysis with a complementary log-log link modeled time-varying exposures and covariates. Subgroup analyses were stratified by the employment status of returning adult children. Results: Parents whose adult children returned had a significantly higher depression incidence (40.2 vs. 13.6 per 1000 person-years, HR 2.00), especially when the returning child was unemployed (HR 1.35). Co-residence was not significantly associated with depression among adult children (HR 0.54). The highest risk for adult children was among those unemployed and living apart (HR 1.23). Conclusions: Co-residence following adult children's return was linked to increased depression risk in parents especially when the returning child was unemployed. These findings highlight the need for intergenerational policies that reduce emotional and financial burdens on older adults. Fri, 01 May 2026 00:00:00 GMT https://ir.ymlib.yonsei.ac.kr/handle/22282913/211946 2026-05-01T00:00:00Z https://ir.ymlib.yonsei.ac.kr/handle/22282913/211239 Title: Sex-specific associations of creatinine and antioxidant biomarkers with lung cancer risk by drinking and smoking behavior: A prospective cohort study Authors: Shin, Jong Won; Sull, Jae Woong; Minh, Nguyen Thien; Jee, Sun Ha. Abstract: Background: This study aimed to evaluate the associations between serum creatinine, a potential antioxidant marker, and major endogenous antioxidant biomarkers with lung cancer risk, stratified by sex, alcohol consumption, and smoking status. Methods: We analyzed 133,596 cancer-free adults from the Korean Cancer Prevention Study II (KCPS-II) cohort. During a mean follow-up of 13.5 years, 721 incident lung cancer cases were identified. Serum levels of creatinine, total bilirubin, albumin, and uric acid were measured. Alcohol consumption and smoking status were classified as never, former, current, and ever users, with ever users including both current and former users. Individuals with both alcohol and smoking exposure were additionally analyzed as a high-risk group. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for lung cancer, stratified by alcohol and smoking status. Biomarkers were analyzed by quartiles and linear trends. Results: A 1-SD increase in serum creatinine was inversely associated with lung cancer risk in the overall population, including current drinkers (HR: 0.85, 95 % CI: 0.73-0.98), ever drinkers (HR: 0.85, 95 % CI: 0.75-0.97), former smokers (HR: 0.77, 95 % CI: 0.62-0.96), and ever smokers (HR: 0.81, 95 % CI: 0.70-0.93). In men, similar associations were observed in current drinkers (HR: 0.83, 95 % CI: 0.72-0.97), ever drinkers (HR: 0.86, 95 % CI: 0.75-0.99), former smokers (HR: 0.77, 95 % CI: 0.62-0.96), and ever smokers (HR: 0.80, 95 % CI: 0.70-0.92). High-risk groups exposed to both smoking and alcohol showed consistent inverse associations, with current smokers who were also current drinkers (HR: 0.81, 95 % CI: 0.66-1.00), and ever smokers who were also ever drinkers (HR: 0.78, 95 % CI: 0.67-0.91). No significant association was observed in women. Conclusions: In men, serum creatinine showed a strong inverse association with lung cancer risk under oxidative stress conditions related to smoking and alcohol consumption. Wed, 01 Apr 2026 00:00:00 GMT https://ir.ymlib.yonsei.ac.kr/handle/22282913/211239 2026-04-01T00:00:00Z https://ir.ymlib.yonsei.ac.kr/handle/22282913/211456 Title: Estimation of healthy worker survivor bias among middle-aged populations in Korea Authors: Yun, Byungyoon; Kim, Beom Kyung; Jang, Sung-In; Rozek, Laura S.; Kimm, Heejin; Oh, Juyeon; Yoon, Jin-Ha Abstract: Background Healthy worker survivor bias (HWSB) skews health outcome studies by favouring healthier employed individuals. While advanced statistical methods exist, their application in Korea has been limited due to insufficient occupational and mortality data. This study quantifies HWSB due to employment status changes (HWSB-ES) using Korea's National Health Insurance Service (NHIS) database.Methods This retrospective cohort study analysed NHIS data to assess HWSB-ES in individuals aged 30-59 years who maintained consistent insurance types from 2008 to 2010. The primary outcome, all-cause mortality, was tracked until December 2022. Insurance type determined employment status, with industry details collected for employees. Landmark analysis (origin: 2011; current: 2012-21) estimated HWSB-ES by assessing mortality risk attenuation in fixed and dynamic cohorts, stratified by age, sex, and landmark periods (1-10 years for short-term; 1-7 years for long-term).Results After exclusions, 18 192 989 participants were included (median age: 44 years; 49.05% male). HWSB-ES was more pronounced in female, dynamic cohorts, and longer landmark periods. Importantly, the effect of HWSB-ES intensified with age but showed a smaller long-term attenuation compared to the short-term effect. Short-term HWSB-ES attenuated mortality risk by 25%-30% in male and 36%-39% in female. Long-term attenuation was lower, at 7%-15% in male and 12%-18% in female.Conclusions The quantified HWSB-ES results provide critical national-level estimates for adjustment, especially in female and older cohorts, to prevent the underestimation of adverse health effects in occupational research. Wed, 01 Apr 2026 00:00:00 GMT https://ir.ymlib.yonsei.ac.kr/handle/22282913/211456 2026-04-01T00:00:00Z