https://ir.ymlib.yonsei.ac.kr/handle/22282913/168928 Tue, 16 Jun 2026 07:10:33 GMT 2026-06-16T07:10:33Z https://ir.ymlib.yonsei.ac.kr/handle/22282913/211871 Title: Impact of social media use in static and dynamic functional network connectivity of social anxiety disorder Authors: Kim, Hesun Erin; Kim, Byung-Hoon; Cho, Yesol; Ko, Yujin; Kim, Jae-Jin Abstract: Although social media use patterns are related to social anxiety disorder (SAD), their modulatory relationship with functional network connectivity (FNC) change remains unexplored. This study aims to address this question by utilizing static and dynamic FNC analyses. Using resting-state fMRI data from 45 SAD patients and 43 healthy controls (HC) across two acquisition timepoints (baseline, 2-month follow-up), we examined static and dynamic FNC. Standard region-of-interest (ROI)-to-ROI analysis was performed for static FNC. Dynamic FNC was analyzed using sliding-window and kmeans clustering approach. Social media usage was differentiated between messaging (MSG) and social platform (SP) across four time-of-day segments. Influences of digital social behavior were assessed through correlation analysis. Patients showed decreased static connectivity within cognitive control networks, particularly involving the default mode network. Dynamic FNC analysis identified four brain states, with SAD showing altered temporal dynamics. Specifically, patients exhibited abnormalities in the temporal properties of State 1, characterized as an internally focused state linked to self-referential processing. Lowered State 1 occurrence at follow-up was associated with higher social media use-MSG use in HC and SP use in SAD. Greater SP use was related to increased engagements of an externally vigilant state (State 3) in SAD. Aberrant temporal properties in SAD illustrate difficulties disengaging from maladaptive self-referential processing and a propensity toward heightened sensory vigilance. Furthermore, social media use, particularly content-based SP, may modulate brain dynamics related to introspection and external processing among patients. The findings underscore comprehensive neurobiological underpinnings of SAD and impacts of digital social behavior. Sat, 01 Aug 2026 00:00:00 GMT https://ir.ymlib.yonsei.ac.kr/handle/22282913/211871 2026-08-01T00:00:00Z https://ir.ymlib.yonsei.ac.kr/handle/22282913/212113 Title: Network analysis of item-level neuroticism in recurrent major depression among Korean women Authors: Yu, Hyeona; Park, Jungkyu; Rhee, Sang Jin; Min, Sooyeon; Song, Yoojin; Lee, Heon-Jeong; Won, Seunghee; Lee, Kyu Young; Ko, YoungHoon; Choi, KwangYeon; Jo, Young Tak; Cho, Sung Joon; Lee, Hwayoung; Kang, Won Sub; Moon, Seok Woo; Lee, Yunna; Seo, Junho; Kim, Ga Eun; Kim, Se Joo; Ko, MinSoo; Yun, Ji-ae; Cheon, Eun-Jin; Moon, Eunsoo; Choi, Mal Rye; Ha, Tae Hyon; Lee, Jakyung; Kim, Jee Wook; Flint, Jonathan; Ahn, Yong Min; Myung, Woojae; Kendler, Kenneth S. Abstract: Background: Neuroticism is a core personality trait strongly associated with Major Depressive Disorder (MDD), influencing both its onset and recurrence, and suggesting a persistent vulnerability to depression. Methods: The study included 2997 women with recurrent MDD and 3046 female controls. Neuroticism was assessed using the Neuroticism scale of the Eysenck Personality Questionnaire. Networks were estimated using the Ising model, community structures derived through Exploratory Graph Analysis, and stability tested via bootstrapping. Network Comparison Tests evaluated structural and connectivity differences between groups, with sensitivity analyses excluding zero-scoring participants. Results: Both groups exhibited a four-community configuration, including tension/agitation, hyperarousal and sleep disturbance, interpersonal sensitivity, and cognitive distress. "Being sensitive" emerged as the most central node, strongly linked to insomnia. Although the network structure was similar, the MDD group showed signif-icantly lower global strength. Bootstrapped analyses confirmed the stability of centrality indices. No significant network differences were found within the MDD group based on episode frequency, melancholia, or suicide risk. Sensitivity analyses showed that excluding zero-scoring controls led to lower global strength in the control group. Limitations: The study focused exclusively on women, which limits the generalizability of the findings to all genders, and relied on self-report questionnaires, which may introduce biases. Conclusion: Neuroticism exhibited a stable structure in both groups, but global connectivity was lower in the MDD group. "Being sensitive" emerged as the central node, suggesting its potential as a target for intervention. Sat, 01 Aug 2026 00:00:00 GMT https://ir.ymlib.yonsei.ac.kr/handle/22282913/212113 2026-08-01T00:00:00Z https://ir.ymlib.yonsei.ac.kr/handle/22282913/212428 Title: Characteristics of subjective well-being and communication in individuals with social anxiety disorder assessed through virtual reality tasks Authors: Cho, Yesol; Kim, Soomin; Kim, Eunji; Kim, Hesun Erin; Kim, Byung-Hoon; Kim, Junhyung; Kim, Jae-Jin Abstract: Individuals with social anxiety disorder (SAD) have difficulty coping with social situations, resulting in a diminished quality of life. This study aimed to investigate subjective well-being and communication-related characteristics using virtual reality (VR) tasks. Twenty-eight individuals with SAD and 25 healthy controls performed VR subjective well-being tasks (recognizing experience-based problems, expressing a future self-based success story, and expressing strengths) and VR communication tasks (exploring the communication style, practicing functional communication, and expressing empathy). The SAD group reported lower anti-difficulty, resolvability, and strength utilization scores and showed lower communication score in response to all dysfunctional communication styles (placating, blaming, computing, distracting) than the control group. These results suggest that diminished quality of life in individuals with SAD can be measured in terms of subjective well-being and communication using VR tasks. Multiple training regimes, including repeated execution of these tasks, may be necessary to improve their quality of life. Sat, 01 Aug 2026 00:00:00 GMT https://ir.ymlib.yonsei.ac.kr/handle/22282913/212428 2026-08-01T00:00:00Z https://ir.ymlib.yonsei.ac.kr/handle/22282913/211533 Title: Extraversion as a mediator of genetic effects on positive affect in Korean adolescent girls Authors: Lee, Sung-Ha; Lim, Hojun; Kim, Kipoong; Youm, Yoosik; Kim, Eunjoo Abstract: Recent genomic findings provide evidence for genetic variation underlying individual differences in well-being, yet the mechanisms through which genetic factors translate into emotional experiences remain poorly understood. Accordingly, this study aims to examine whether a polygenic score (PGS) correlates with positive emotions, thereby addressing the genetic basis of emotional well-being. Moreover, based on prior evidence linking extraversion to both genetic predispositions and positive emotions, we further examined whether extraversion mediates this relationship. Using the PGS for happiness derived from a recent genome-wide association study conducted with Korean populations, we assessed the genetic basis of happiness in relation to positive affect among Korean adolescent girls (N = 211, Mean age = 15.8 yrs (SD = 0.3 yrs)). Mediation analysis revealed a significant indirect effect of happiness PGS on positive affect through extraversion, but no significant direct effect. These findings suggest that genetic influences on well-being exert their effects through personality traits rather than directly modulating emotional states, underscoring the importance of considering mediating psychological constructs in genetic models of well-being. Wed, 01 Jul 2026 00:00:00 GMT https://ir.ymlib.yonsei.ac.kr/handle/22282913/211533 2026-07-01T00:00:00Z