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Impact of social media use in static and dynamic functional network connectivity of social anxiety disorder

Sat, 01 Aug 2026 00:00:00 GMT

Title: Impact of social media use in static and dynamic functional network connectivity of social anxiety disorder Authors: Kim, Hesun Erin; Kim, Byung-Hoon; Cho, Yesol; Ko, Yujin; Kim, Jae-Jin Abstract: Although social media use patterns are related to social anxiety disorder (SAD), their modulatory relationship with functional network connectivity (FNC) change remains unexplored. This study aims to address this question by utilizing static and dynamic FNC analyses. Using resting-state fMRI data from 45 SAD patients and 43 healthy controls (HC) across two acquisition timepoints (baseline, 2-month follow-up), we examined static and dynamic FNC. Standard region-of-interest (ROI)-to-ROI analysis was performed for static FNC. Dynamic FNC was analyzed using sliding-window and kmeans clustering approach. Social media usage was differentiated between messaging (MSG) and social platform (SP) across four time-of-day segments. Influences of digital social behavior were assessed through correlation analysis. Patients showed decreased static connectivity within cognitive control networks, particularly involving the default mode network. Dynamic FNC analysis identified four brain states, with SAD showing altered temporal dynamics. Specifically, patients exhibited abnormalities in the temporal properties of State 1, characterized as an internally focused state linked to self-referential processing. Lowered State 1 occurrence at follow-up was associated with higher social media use-MSG use in HC and SP use in SAD. Greater SP use was related to increased engagements of an externally vigilant state (State 3) in SAD. Aberrant temporal properties in SAD illustrate difficulties disengaging from maladaptive self-referential processing and a propensity toward heightened sensory vigilance. Furthermore, social media use, particularly content-based SP, may modulate brain dynamics related to introspection and external processing among patients. The findings underscore comprehensive neurobiological underpinnings of SAD and impacts of digital social behavior.

Characteristics of subjective well-being and communication in individuals with social anxiety disorder assessed through virtual reality tasks

Sat, 01 Aug 2026 00:00:00 GMT

Title: Characteristics of subjective well-being and communication in individuals with social anxiety disorder assessed through virtual reality tasks Authors: Cho, Yesol; Kim, Soomin; Kim, Eunji; Kim, Hesun Erin; Kim, Byung-Hoon; Kim, Junhyung; Kim, Jae-Jin Abstract: Individuals with social anxiety disorder (SAD) have difficulty coping with social situations, resulting in a diminished quality of life. This study aimed to investigate subjective well-being and communication-related characteristics using virtual reality (VR) tasks. Twenty-eight individuals with SAD and 25 healthy controls performed VR subjective well-being tasks (recognizing experience-based problems, expressing a future self-based success story, and expressing strengths) and VR communication tasks (exploring the communication style, practicing functional communication, and expressing empathy). The SAD group reported lower anti-difficulty, resolvability, and strength utilization scores and showed lower communication score in response to all dysfunctional communication styles (placating, blaming, computing, distracting) than the control group. These results suggest that diminished quality of life in individuals with SAD can be measured in terms of subjective well-being and communication using VR tasks. Multiple training regimes, including repeated execution of these tasks, may be necessary to improve their quality of life.

Clinical impact of local consolidative therapy in EGFR-mutant metastatic NSCLC: A propensity-matched multicenter analysis

Wed, 01 Jul 2026 00:00:00 GMT

Title: Clinical impact of local consolidative therapy in EGFR-mutant metastatic NSCLC: A propensity-matched multicenter analysis Authors: Lee, Eun Hye; Kim, Mi-Hyun; Kang, Da Hyun; Moon, Jisu; Kwak, Se Hyun; Eom, Jung Seop; Lee, Jeong Eun; Kim, Chi Young; Chang, Yoon Soo; Lee, Sang Hoon; Kim, Eun Young; Lee, Chang Young; Cho, Jaeho; 문지수 Abstract: Objectives To evaluate the impact of consolidative surgery and radiotherapy (RT) on survival outcomes in patients with advanced or metastatic epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) treated with EGFR tyrosine kinase inhibitors (TKIs). Methods This retrospective, multicenter cohort study included 864 patients with EGFR-mutant advanced or metastatic NSCLC receiving first-line EGFR-TKIs. Patients were categorized into EGFR-TKI monotherapy (n = 616), TKI plus surgery (n = 100), and TKI plus RT (n = 148). Propensity score matching (PSM) and overlap weighting were applied to balance baseline characteristics. Overall survival (OS) and progression-free survival (PFS) were analyzed using Cox proportional hazards models and restricted mean survival time (RMST). Results After PSM, 97 matched pairs were generated for TKI versus TKI plus surgery and 148 pairs for TKI versus TKI plus RT. Compared with TKI alone, consolidative surgery significantly improved OS (hazard ratio [HR], 0.36; 95% CI, 0.20-0.65; p < 0.001) and PFS (HR, 0.48; 95% CI, 0.34-0.67; p < 0.001), with RMST gains of 10.7 and 10.6 months.Consolidative RT showed a trend toward longer OS (HR, 0.61; 95% CI, 0.39-0.93; p = 0.023)without significant PFS or consistent RMST benefit. Subgroup analyses showed surgery benefit in younger patients with good performance, lower metastatic burden, and no brain metastasis, whereas RT effects were heterogeneous. Conclusion In this real-world cohort, consolidative surgery combined with EGFR-TKI was associated with a clear survival benefit in advanced EGFR-mutant NSCLC while the effect of consolidative RT was less consistent, highlighting the importance of careful patient selection and multidisciplinary management.

Cardiovascular outcomes with thiazolidinediones and sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus undergoing peripheral artery revascularization

Mon, 01 Jun 2026 00:00:00 GMT

Title: Cardiovascular outcomes with thiazolidinediones and sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus undergoing peripheral artery revascularization Authors: Roh, Ji Woong; Jeon, Jimin; Yoo, Joonsang; Baik, Minyoul; Heo, Seok-Jae; Cho, Deok-Kyu; Kim, Jinkwon Abstract: Aims: The comparative effectiveness of anti-diabetic agents in patients with type 2 diabetes mellitus (T2DM) undergoing peripheral artery revascularization remains unclear. Methods: Using the Korean National Health Insurance Claims database (2015-2023), we identified patients with T2DM who underwent peripheral artery revascularization (endovascular or surgical). To control for baseline differences, we utilized 1:3 propensity score matching to compare thiazolidinediones (TZD) vs. dipeptidyl peptidase-4 inhibitors (DPP-4i), and sodium-glucose co-transporter-2 inhibitors (SGLT-2i) vs. DPP-4i. Stratified Cox regression model assessed the risk for the primary outcome, defined as a composite of major adverse limb events (repeated revascularization or amputation), stroke, myocardial infarction, admission for heart failure, and all-cause death. Results: The primary outcome occurred in 49.3% of TZD users versus 55.5% of DPP-4i users (HR 0.74; 95% CI 0.63-0.86; p <0.001) and in 39.7% of SGLT-2i users versus 52.2% of DPP-4i users (HR 0.88; 95% CI 0.79-0.98; p = 0.015). Regarding secondary outcomes, TZD users were associated with lower risks of major adverse limb events, and all-cause death compared with DPP-4i users. SGLT-2i treatment was associated with reduced allcause death. Conclusions: Among patients with T2DM undergoing peripheral artery revascularization, TZD and SGLT-2i were associated with favourable clinical outcomes compared to DPP-4i.