https://ir.ymlib.yonsei.ac.kr/handle/22282913/205275 2026-04-13T15:19:52Z 2026-04-13T15:19:52Z Shin, Jong Won Sull, Jae Woong Minh, Nguyen Thien Jee, Sun Ha. https://ir.ymlib.yonsei.ac.kr/handle/22282913/211239 2026-03-16T04:50:05Z 2026-04-01T00:00:00Z

Title: Sex-specific associations of creatinine and antioxidant biomarkers with lung cancer risk by drinking and smoking behavior: A prospective cohort study Authors: Shin, Jong Won; Sull, Jae Woong; Minh, Nguyen Thien; Jee, Sun Ha. Abstract: Background: This study aimed to evaluate the associations between serum creatinine, a potential antioxidant marker, and major endogenous antioxidant biomarkers with lung cancer risk, stratified by sex, alcohol consumption, and smoking status. Methods: We analyzed 133,596 cancer-free adults from the Korean Cancer Prevention Study II (KCPS-II) cohort. During a mean follow-up of 13.5 years, 721 incident lung cancer cases were identified. Serum levels of creatinine, total bilirubin, albumin, and uric acid were measured. Alcohol consumption and smoking status were classified as never, former, current, and ever users, with ever users including both current and former users. Individuals with both alcohol and smoking exposure were additionally analyzed as a high-risk group. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for lung cancer, stratified by alcohol and smoking status. Biomarkers were analyzed by quartiles and linear trends. Results: A 1-SD increase in serum creatinine was inversely associated with lung cancer risk in the overall population, including current drinkers (HR: 0.85, 95 % CI: 0.73-0.98), ever drinkers (HR: 0.85, 95 % CI: 0.75-0.97), former smokers (HR: 0.77, 95 % CI: 0.62-0.96), and ever smokers (HR: 0.81, 95 % CI: 0.70-0.93). In men, similar associations were observed in current drinkers (HR: 0.83, 95 % CI: 0.72-0.97), ever drinkers (HR: 0.86, 95 % CI: 0.75-0.99), former smokers (HR: 0.77, 95 % CI: 0.62-0.96), and ever smokers (HR: 0.80, 95 % CI: 0.70-0.92). High-risk groups exposed to both smoking and alcohol showed consistent inverse associations, with current smokers who were also current drinkers (HR: 0.81, 95 % CI: 0.66-1.00), and ever smokers who were also ever drinkers (HR: 0.78, 95 % CI: 0.67-0.91). No significant association was observed in women. Conclusions: In men, serum creatinine showed a strong inverse association with lung cancer risk under oxidative stress conditions related to smoking and alcohol consumption.

2026-04-01T00:00:00Z Yun, Byungyoon Kim, Beom Kyung Jang, Sung-In Rozek, Laura S. Kimm, Heejin Oh, Juyeon Yoon, Jin-Ha https://ir.ymlib.yonsei.ac.kr/handle/22282913/211456 2026-03-25T06:50:22Z 2026-04-01T00:00:00Z

Title: Estimation of healthy worker survivor bias among middle-aged populations in Korea Authors: Yun, Byungyoon; Kim, Beom Kyung; Jang, Sung-In; Rozek, Laura S.; Kimm, Heejin; Oh, Juyeon; Yoon, Jin-Ha Abstract: Background Healthy worker survivor bias (HWSB) skews health outcome studies by favouring healthier employed individuals. While advanced statistical methods exist, their application in Korea has been limited due to insufficient occupational and mortality data. This study quantifies HWSB due to employment status changes (HWSB-ES) using Korea's National Health Insurance Service (NHIS) database.Methods This retrospective cohort study analysed NHIS data to assess HWSB-ES in individuals aged 30-59 years who maintained consistent insurance types from 2008 to 2010. The primary outcome, all-cause mortality, was tracked until December 2022. Insurance type determined employment status, with industry details collected for employees. Landmark analysis (origin: 2011; current: 2012-21) estimated HWSB-ES by assessing mortality risk attenuation in fixed and dynamic cohorts, stratified by age, sex, and landmark periods (1-10 years for short-term; 1-7 years for long-term).Results After exclusions, 18 192 989 participants were included (median age: 44 years; 49.05% male). HWSB-ES was more pronounced in female, dynamic cohorts, and longer landmark periods. Importantly, the effect of HWSB-ES intensified with age but showed a smaller long-term attenuation compared to the short-term effect. Short-term HWSB-ES attenuated mortality risk by 25%-30% in male and 36%-39% in female. Long-term attenuation was lower, at 7%-15% in male and 12%-18% in female.Conclusions The quantified HWSB-ES results provide critical national-level estimates for adjustment, especially in female and older cohorts, to prevent the underestimation of adverse health effects in occupational research.

2026-04-01T00:00:00Z Yang, Yeun Soo Zhang, Hyun Soo Kimm, Heejin Jung, Keum Ji Kim, Soyoung Baek, Ji Woo Lee, Sunmi Ha Jee, Sun https://ir.ymlib.yonsei.ac.kr/handle/22282913/211525 2026-03-26T02:47:48Z 2026-03-01T00:00:00Z

Title: Adiponectin as a Predictor of Metabolic Dysfunction-Associated Steatotic Liver Disease and Non-Alcoholic Fatty Liver Disease: A 17-Year Korean Cohort Study (Diabetes Metab J 2026;50:331-42) Authors: Yang, Yeun Soo; Zhang, Hyun Soo; Kimm, Heejin; Jung, Keum Ji; Kim, Soyoung; Baek, Ji Woo; Lee, Sunmi; Ha Jee, Sun

2026-03-01T00:00:00Z Yang, Yeun Soo Zhang, Hyun Soo Kimm, Heejin Jung, Keum Ji Kim, Soyoung Baek, Ji Woo Lee, Sunmi Jee, Sun Ha https://ir.ymlib.yonsei.ac.kr/handle/22282913/211524 2026-03-26T02:47:47Z 2026-03-01T00:00:00Z

Title: Adiponectin as a Predictor of Metabolic Dysfunction-Associated Steatotic Liver Disease and Non-Alcoholic Fatty Liver Disease: A 17-Year Korean Cohort Study Authors: Yang, Yeun Soo; Zhang, Hyun Soo; Kimm, Heejin; Jung, Keum Ji; Kim, Soyoung; Baek, Ji Woo; Lee, Sunmi; Jee, Sun Ha Abstract: Background: This study aimed to investigate the association between adiponectin levels and the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) and nonalcoholic fatty liver disease (NAFLD), and to explore the predictive value of adiponectin in the onset of these conditions. Methods: A 17-year follow-up of 35,026 individuals from the Korean Cancer Prevention Study-II biobank cohort (2004-2021) was conducted. Adiponectin levels were categorized into quintiles. Outcomes were defined as: NAFLD (10th revision of the International Classification of Diseases [ICD-10] K76.0); MASLD (K76.0 with cardiometabolic factors); NAFLD-cardiometabolic (K76.0 without cardiometabolic factors); and non-steatotic liver disease. The cause-specific Cox model accounted for death as a competing risk, with interaction terms for non-proportional hazards. Results: Our findings indicated a heightened risk of MASLD in individuals in low adiponectin groups. Hazard ratios (HRs) for different adiponectin levels, using Gadipo 5 (>= 17.21 mu g/mL) as the reference, were: Gadipo 1, HR 3.20 (95% confidence interval [CI], 2.08 to 4.92); Gadipo 2, HR 2.45 (95% CI, 1.59 to 3.76); Gadipo 3, HR 2.02 (95% CI, 1.32 to 3.11); and Gadipo 4, HR 1.59 (95% CI, 1.02 to 2.46). These associations remained consistent across outcomes and models. Sex stratification revealed a stronger association among females. Furthermore, lower adiponectin levels were associated with increased MASLD and NAFLD risk. Similar associations were also observed in individuals with NAFLD-cardiometabolic, indicating consistency across subtypes. Conclusion: Different adiponectin levels revealed distinct risks. This study emphasizes adiponectin's potential as a predictive indicator of MASLD and NAFLD, stressing the need for further investigation across diverse demographic groups.

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