https://ir.ymlib.yonsei.ac.kr/handle/22282913/169037 2026-07-06T07:54:50Z 2026-07-06T07:54:50Z Lee, Min-Yong Mangal, Utkarsh Yoon, Hi-Won Im, Hyungsoon Choi, Sung-Hwan Kwon, Jae Sung Shin, Su-Jung https://ir.ymlib.yonsei.ac.kr/handle/22282913/212418 2026-06-09T06:14:46Z 2026-11-01T00:00:00Z

Title: Microfluidic pulp platform with vascular integration to evaluate biofunctional material Authors: Lee, Min-Yong; Mangal, Utkarsh; Yoon, Hi-Won; Im, Hyungsoon; Choi, Sung-Hwan; Kwon, Jae Sung; Shin, Su-Jung Abstract: Biofunctional materials are increasingly used to preserve tooth vitality by promoting dental pulp-mediated hard tissue formation. However, existing evaluation platforms, such as conventional in vitro assays or microfluidic systems, fail to replicate the complex histological and physiological characteristics of dental pulp. This study introduces a 4D biofunctional material-to-pulp (4D BFP) platform that recapitulates pulp physiology, integrating three key features of native pulp tissue: layered histoarchitecture, microcirculatory dynamics, and threedimensional multicellular organization. This platform further incorporates a temporal dimension by simulating age-dependent vascular transitions, thereby enabling the age-specific modelling of pulp responses, and defining the system as a 4D microfluidic pulp model. Computational fluid dynamics confirmed physiologically relevant flow profiles, while the compartmentalized design supported the spatially organized co-culture of endothelial cell (EC) and human dental pulp stem cell (hDPSC) spheroids. Functional responses to biofunctional material were assessed in both young and mature 4D pulp models. Transcriptomic profiling revealed distinct age-and material-specific signatures related to cellular growth arrest, angiogenesis, and developmental pathways. Collectively, the 4D BFP platform provides a physiological and temporal biomimetic model to study biomaterial-dental pulp interactions, supporting its application as a primary screening tool for candidate biofunctional materials.

2026-11-01T00:00:00Z Hong, Hyeon Gi Nguyen, Hieu Alkhamees, Amani Lee, Kee-Joon https://ir.ymlib.yonsei.ac.kr/handle/22282913/210269 2026-02-05T00:26:14Z 2026-06-01T00:00:00Z

Title: Non-surgical treatment of adult skeletal class III patient with severe alveolar bone loss by sequential segmental displacement and third molar extraction: A case report Authors: Hong, Hyeon Gi; Nguyen, Hieu; Alkhamees, Amani; Lee, Kee-Joon Abstract: Compromised periodontal conditions pose challenges in orthodontic treatment. In particular, maxillomandibular skeletal discrepancies may require large-scale tooth movement, making it essential to avoid round-tripping movements to minimize dental and periodontal side effects. This case report describes a 49-year-old male patient with skeletal Class III malocclusion and severe alveolar bone loss, particularly affecting the anterior teeth, who sought non-surgical treatment with aesthetic lingual orthodontic appliances. A comprehensive diagnosis and treatment plan were formulated to establish a flat occlusal plane and Class I molar relationship while minimizing round-tripping of the anterior segment. Segmental distalization of mandibular molars, followed by intrusion of the mandibular incisors, was performed with the aid of miniscrews to achieve normal occlusion and an improved facial profile without further alveolar bone loss. This case report highlights the use of segmental archwires and an orthodontic force system based on the centre of resistance to preserve periodontal support in a middle-aged patient with skeletal Class III malocclusion and severe alveolar bone loss.

2026-06-01T00:00:00Z Mangal, Utkarsh Jinn, Hyeonseok Hyun, Chang Min Kim, Harim Cha, Jung Yul Lee, Kee-Joon Choi, Sung-Hwan 만갈 웃커시 https://ir.ymlib.yonsei.ac.kr/handle/22282913/211531 2026-03-26T05:07:06Z 2026-05-01T00:00:00Z

Title: Facial surface tracing approach to reduce the observation errors in 3D curvilinear landmark annotations on cone-beam computed tomography images Authors: Mangal, Utkarsh; Jinn, Hyeonseok; Hyun, Chang Min; Kim, Harim; Cha, Jung Yul; Lee, Kee-Joon; Choi, Sung-Hwan; 만갈 웃커시 Abstract: Objectives: To propose and validate a 3D facial surface tracing (3D-FAST) algorithm as a robust tracing method to reduce observation errors in identifying maxillofacial curvilinear landmarks. Methods: The 3D-FAST algorithm comprises four sequential steps: (1) extraction of bone structures from cone-beam computed tomography (CBCT) volumes utilizing Otsu's thresholding method; (2) conversion of segmented volumetric data into a mesh representation through the marching-cubes algorithm; (3) initial landmark identification employing a data-driven approach, followed by selective manual refinement; and (4) optimization of landmark positions by identifying maximal or minimal points within defined curvilinear regions. The algorithm's efficiency was validated using 55 CBCT datasets, with particular emphasis on the Orbitale landmark. Annotation efficiency was assessed by comparing landmark deviations, dihedral angles between reference planes, and asymmetry measurements with independent manually annotated datasets. Results: Compared to orthodontically trained CBCT users, 3D-FAST demonstrated the highest consistency with the centroid derived from user annotations. In constructing horizontal and vertical reference planes and conducting asymmetry analyses, reference planes generated by 3D-FAST showed significantly improved dihedral angle variation and asymmetry than those generated by an experienced CBCT human observer, the most consistent and experienced manual user. In addition, 3D-FAST achieved improved consistency when bilateral Orbitale landmarks were used for reference plane construction, compared to when unilateral Orbitale landmarks were used. Conclusions: 3D-FAST is a reliable method for annotating curvilinear landmarks in CBCT images. Clinical significance: 3D-FAST has the potential to enhance clinical workflows and outcomes by reducing the learning curve, minimizing subjectivity, and saving time.

2026-05-01T00:00:00Z Choi, Eun-Hack Andrew Noda, Mayu Choi, Sung-Hwan Cho, Hyung-Ju Iwasaki, Tomonori Cha, Jung-Yul https://ir.ymlib.yonsei.ac.kr/handle/22282913/212478 2026-06-10T05:55:31Z 2026-05-01T00:00:00Z

Title: Associations of miniscrew length with long-term skeletal, dentoalveolar, and nasal airflow changes after miniscrew-assisted rapid palatal expansion: A retrospective cohort study Authors: Choi, Eun-Hack Andrew; Noda, Mayu; Choi, Sung-Hwan; Cho, Hyung-Ju; Iwasaki, Tomonori; Cha, Jung-Yul Abstract: Introduction: This study aimed to evaluate the associations between miniscrew length and long-term skeletal, dentoalveolar, and nasal airflow changes after miniscrew-assisted rapid palatal expansion (MARPE). Methods: This retrospective study included 32 adult patients with successful midpalatal suture separation MARPE with either long (n = 15) or short (n = 17) miniscrews. Cone-beam computed tomography scans obtained at pretreatment (T0), postexpansion (T1), and follow-up (T2). Skeletal and dentoalveolar changes were assessed using 3-dimensional landmark analysis. Nasal airflow was evaluated using computational fluid dynamics (pressure-flow ratio and maximum airflow velocity). Between-group and within-group comparisons and correlation analyses were performed. Results: A significant time & times; group interaction observed for inter-processus zygomaticus width (P = 0.002), with the long miniscrew group showing greater skeletal expansion than the short miniscrew group (mean difference at T2-T0: 1.15 mm). No significant group differences in nasal airflow outcomes were observed at any time point. Significant long-term improvements (T2-T0) in pressure-flow ratio and maximum velocity were observed in both groups, exceeding the changes seen immediately after expansion (T1-T0). Correlation analysis revealed that baseline nasal airflow parameters were stronger predictors of functional improvement than the magnitude maxillary expansion. Conclusions: Among successful cases, MARPE with long miniscrews was associated with greater long-term skeletal expansion at the maxillary basal bone level than with short miniscrews. Although nasal airflow improved after MARPE, the magnitude of improvement did not differ by miniscrew length and appeared more related to baseline nasal functional status. (Am J Orthod Dentofacial Orthop 2026;169:654-70)

2026-05-01T00:00:00Z