https://ir.ymlib.yonsei.ac.kr/handle/22282913/168826 2026-04-15T20:35:46Z 2026-04-15T20:35:46Z Cho, Sungwoo Ha, Hyun-Su Lee, Sangmin Kim, Hyunjae Lee, Seok Joon Kim, Jueun Lee, Yerin Lee, Kang Suk Joo, Hyun-Chel Sung, Hak-Joon 하현수 이예린 https://ir.ymlib.yonsei.ac.kr/handle/22282913/211299 2026-03-16T07:23:46Z 2026-05-01T00:00:00Z

Title: A large puncture closer of aortic wall by multi-memory actions with thrombo-hemodynamic control Authors: Cho, Sungwoo; Ha, Hyun-Su; Lee, Sangmin; Kim, Hyunjae; Lee, Seok Joon; Kim, Jueun; Lee, Yerin; Lee, Kang Suk; Joo, Hyun-Chel; Sung, Hak-Joon; 하현수; 이예린 Abstract: The vascular wall regulates the pattern and pressure of blood flow. In cardiovascular interventions, catheters are deployed by puncturing the vessel wall, without exception. Despite continuous progress, the outcomes remain highly operator-dependent, and large punctures with high-pressure bleeding continue to pose clinical challenges. As a translatable solution, this study introduces a shape memory vascular wall plug (VWP) that automates both the Body and Wing functions within a single component, supported by a Ring assembly to maximize pressure resistance. The VWP is deployed into a 6-mm puncture in a porcine thoracic aorta under peak blood pressure, and shape recovery is triggered by a 45 degrees C saline flush to enable automated activation. Upon recovery, Body expansion combined with Ring compression tightly seals the puncture tract. The curved Wing induces hemostatic sealing and then flattens to maintain healthy blood flow and physiologic pressures. The VWP achieves suturinglevel performance in aortic puncture closure, demonstrating effective hemostasis, patency, and endothelialization. The flow-blockage ratio required to balance hemostasis with hemodynamics is computationally modeled and validated using whole-blood microfluidics. Pressure resistance is maximized by tuning Ring strain through polymer blending, indicating multi-level strategies in polymer, device design, and memory function to advance the vascular closure technology.

2026-05-01T00:00:00Z Cho, Junghyun Son, Heeju Kim, Jayoung Song, Hyun Seok Lee, Wonryung https://ir.ymlib.yonsei.ac.kr/handle/22282913/211301 2026-03-16T07:17:13Z 2026-04-01T00:00:00Z

Title: Wearable microneedle sensors for continuous interstitial fluid monitoring Authors: Cho, Junghyun; Son, Heeju; Kim, Jayoung; Song, Hyun Seok; Lee, Wonryung Abstract: Wearable microneedle (MN) sensors for continuous interstitial fluid (ISF) monitoring are emerging as transformative tools for real-time biochemical profiling in healthcare. Unlike point-of-care (POC) devices that provide single-time-point results, continuous MN systems deliver time-resolved molecular data over extended periods, enabling detection of rapid physiological changes and supporting timely, personalized interventions. This review focuses exclusively on continuous MN systems designed for on-body, long-term operation, integrating engineering fundamentals, clinical application priorities, and translational strategies for MN-based electrochemical ISF sensing. We describe how MN architecture, materials, and fabrication methods are optimized for long-term in vivo performance and outline core sensing modalities with an emphasis on electrochemical approaches. Three clinical domains are highlighted: chronic disease management, early disease detection, and therapeutic drug monitoring, each imposing distinct technical and operational challenges. Cross-cutting requirements such as antifouling, secure skin adhesion, and closed-loop integration are critically examined. Regulatory readiness and clinical workflow integration are discussed to align MN technologies with established pathways. By linking technical progress to clinical translation, this review provides a practical roadmap to accelerate MN-based continuous monitoring from laboratory innovation to real-world adoption.

2026-04-01T00:00:00Z Kim, Hyeong-Min Kim, Min-Jun Sung, Wonjung Youn, Yuna Park, Jihoon Hwang, Jin-Hyeok Lee, Jong-chan Yoon, Seokhyun Park, Jae-Hyoung Lee, Seung-Ki https://ir.ymlib.yonsei.ac.kr/handle/22282913/210268 2026-01-27T05:37:28Z 2026-03-01T00:00:00Z

Title: Sensitive fiber-optic localized surface plasmon resonance sensor for early pancreatic cancer detection via carbohydrate antigen 19-9 and supplementary biomarkers Authors: Kim, Hyeong-Min; Kim, Min-Jun; Sung, Wonjung; Youn, Yuna; Park, Jihoon; Hwang, Jin-Hyeok; Lee, Jong-chan; Yoon, Seokhyun; Park, Jae-Hyoung; Lee, Seung-Ki Abstract: Early detection of pancreatic cancer remains a major clinical challenge with the limited specificity of representative biomarker such as carbohydrate antigen 19-9 (CA19-9). CA19-9 with traditional methods including enzyme-linked immunosorbent assay (ELISA) are primarily used to monitor treatment responses and predict prognosis. This study describes the potential of CA19-9 as an indicator for early diagnosis of pancreatic cancer using a sensitive fiber-optic localized surface plasmon resonance (FO LSPR) sensor. The FO LSPR technology detected CA19-9 within 10 min, with a detection limit about 1.6 orders of magnitude lower (6.89 mU/mL) than that of ELISA. When CA19-9 was quantified in 150 samples, a Pearson correlation coefficient of 0.937 was demonstrated using ELISA, and our sensor better distinguished early patients from healthy controls. FO LSPR uncovered subtle right-skewed gradients of CA19-9 within the normal range that were undetectable by ELISA. The sensitivity for >99 % specificity and the area under the curve for the discrimination of patients and healthy individuals improved to 0.692 and 0.936, respectively, compared with those of ELISA (0.515 and 0.893, respectively). These results mean that FO LSPR liquid biopsy helps identify new roles of CA19-9 in pancreatic cancer diagnosis. Moreover, using FO LSPR measurements of two supplementary markers, apolipoprotein A1 and interleukin 8, the diagnostic power was improved, with statistically significant differences from that obtained using CA19-9 alone, specifically for the discrimination of early pancreatic ductal adenocarcinoma. In conclusion, the FO LSPR system provides a simple, rapid, and reproducible analytical platform that overcomes key limitations of conventional immunoassays.

2026-03-01T00:00:00Z Jang, Jaehwan Park, Byeong-Sun Oh, Kyeong Taek Yoo, Seong-Jae Im, Seong-Min Khan, Yasser Kim, Min-gu https://ir.ymlib.yonsei.ac.kr/handle/22282913/211652 2026-03-31T01:29:52Z 2026-03-01T00:00:00Z

Title: Complementary visual localization and tactile mapping approach for robotic perception of millimeter-sized objects with irregular surfaces Authors: Jang, Jaehwan; Park, Byeong-Sun; Oh, Kyeong Taek; Yoo, Seong-Jae; Im, Seong-Min; Khan, Yasser; Kim, Min-gu Abstract: Humanoid robots and human-machine interaction technologies are essential for perceiving and manipulating millimeter-scale objects with irregular surfaces in extreme environments, such as outer space, radioactive zones, and hazardous sites with explosive ordnance, where human access is restricted. A vision-based perception approach provides spatial and positional information about objects but relying solely on it for robot manipulation poses challenges due to limitations in detectable object size, as well as sensitivity to external factors such as focusing issues, occlusion, and lighting conditions. In contrast, tactile perception offers valuable information about aspects that are difficult to discern visually, including an object's shape, surface characteristics, and the forces involved during contact. This study presents a complementary visual localization and tactile mapping framework that allows robots to effectively perceive small objects with irregular surfaces in visually restricted environments. The proposed method draws inspiration from the sequential vision-tactile sensory processing observed in humans when handling small objects with irregular surfaces. It employs an RGB-Depth camera for visual perception and a soft pressure sensor array, made using inkjet printing, for tactile perception. We demonstrate the feasibility of implementing a sensory substitution to detect the size and location of objects through visual perception, as well as identify object surfaces and reconstruct their three-dimensional profiles using tactile scanning, particularly in environments where visual information is limited. This study provides a technological foundation for enhancing the autonomy and adaptability of humanoid robots in unpredictable and unstructured environments, particularly to support precise robot manipulation in such conditions.

2026-03-01T00:00:00Z