https://ir.ymlib.yonsei.ac.kr/handle/22282913/168778 2026-06-15T21:57:47Z 2026-06-15T21:57:47Z Zhang, KeLun Park, Chang Ook https://ir.ymlib.yonsei.ac.kr/handle/22282913/211973 2026-04-29T08:26:58Z 2026-04-01T00:00:00Z

Title: mRNA-based allergen-specific immunotherapy to modulate type 2 airway inflammation Authors: Zhang, KeLun; Park, Chang Ook

2026-04-01T00:00:00Z Kim, Myoung Shin Kim, Ho Sung Park, Eun Joo Kim, Hye One Lee, Jungsoo Lee, Dong Hun Jung, Joon Min Chang, Sung Eun Jung, Hye Jung Ko, Joo Yeon Jue, Mihn-Sook Choi, Sun Young Jeon, Jiehyun Kim, Myung Hwa Cheong, Seung Hyun Choi, Young-Jun Lee, Sang Eun Kim, Ki-Ho Lee, Ga-Young https://ir.ymlib.yonsei.ac.kr/handle/22282913/212032 2026-04-30T04:51:24Z 2026-04-01T00:00:00Z

Title: Trends in Contact Sensitization Among Korean Patients: A Multicenter 6-Year Retrospective Patch Test Study Authors: Kim, Myoung Shin; Kim, Ho Sung; Park, Eun Joo; Kim, Hye One; Lee, Jungsoo; Lee, Dong Hun; Jung, Joon Min; Chang, Sung Eun; Jung, Hye Jung; Ko, Joo Yeon; Jue, Mihn-Sook; Choi, Sun Young; Jeon, Jiehyun; Kim, Myung Hwa; Cheong, Seung Hyun; Choi, Young-Jun; Lee, Sang Eun; Kim, Ki-Ho; Lee, Ga-Young Abstract: Background Allergic contact dermatitis is influenced by demographic factors. Updated epidemiologic data are needed to optimise patch test panels and preventive strategies.Objectives To evaluate trends and determinants of allergen sensitization in Korean patients undergoing patch testing.Methods Retrospective analysis of patch test records of 2271 patients at 15 university hospitals in Korea between 2019 and 2024. Patch test reactions were interpreted according to International Contact Dermatitis Research Group criteria. Association with age, sex, and body site was assessed.Results Overall, 57.1% of patients exhibited at least one positive reaction; among patients with positive reactions, 48.7% exhibited multi-sensitizations. Most frequent positive patch reactions were to nickel (29.0%), cobalt (18.2%), and chromium (8.2%). Women were more frequently sensitised to nickel and cobalt. Sensitization to fragrance mix I, Myroxylon pereirae resin, and p-phenylenediamine increased with age, whereas sensitization to thimerosal decreased. Facial involvement was associated with higher sensitization to lanolin alcohol; hand involvement with 2-mercaptobenzothiazole, colophonium, 4-tert-butylphenol formaldehyde resin and thimerosal; and scalp involvement with mercapto mix, 4-tert-butylphenol formaldehyde resin, p-phenylenediamine, and lanolin alcohol.Conclusions Metals, particularly nickel and cobalt, remain the predominant sensitizers in Korea. Age, sex, and localization differences underscore the need for targeted screening and public health strategies.

2026-04-01T00:00:00Z Lee, Eun Jung Kwon, Il Joo Kim, Ji Young Park, Seohyun Han, Hui-ting Hwang, Shinwon Bae, Yu Jeong Kim, A. Ram Alqahtani, Jamal Mohammed Kim, Dong Hyun Lee, Jinu Lee, Si-Hyung Oh, Sang Ho 권일주 https://ir.ymlib.yonsei.ac.kr/handle/22282913/212594 2026-06-12T02:54:07Z 2026-04-01T00:00:00Z

Title: Unanchored by two hits: interferon-γ and mechanical stress synergize to undermine melanocyte adhesion and promote vitiligo Authors: Lee, Eun Jung; Kwon, Il Joo; Kim, Ji Young; Park, Seohyun; Han, Hui-ting; Hwang, Shinwon; Bae, Yu Jeong; Kim, A. Ram; Alqahtani, Jamal Mohammed; Kim, Dong Hyun; Lee, Jinu; Lee, Si-Hyung; Oh, Sang Ho; 권일주 Abstract: Background Vitiligo is a chronic depigmentation disorder caused by selective melanocyte loss. Autoreactive CD8+ T cells are known contributors, but impaired melanocyte-keratinocyte adhesion due to E-cadherin dysfunction has also been implicated.Objectives To identify the key adhesion molecules mediating melanocyte-basement membrane interactions and to investigate their modulation in response to vitiligo-associated factors, including interferon (IFN)-gamma and mechanical stress.Methods Primary human epidermal melanocytes and ex vivo human skin tissues were exposed to IFN-gamma and mechanical stress. To identify key molecules involved in melanocyte adhesion, we integrated RNA sequencing data from prior studies with antibody array profiling. The involvement of focal adhesion-associated proteins in melanocyte-basement membrane attachment was further assessed by confocal imaging of skin from patients with vitiligo, revealing a reduction in these molecules.Results Exposure to IFN-gamma and mechanical stress reduced focal adhesion kinase (FAK) and integrin beta 1 (ITG beta 1) expression in melanocytes and ex vivo human skin, increasing melanocyte detachment. Both molecules were also decreased in basal keratinocytes and melanocytes from the skin of patients with vitiligo compared with healthy controls. Pretreatment with the Janus kinase inhibitor baricitinib, used in vitiligo therapy, reduced melanocyte detachment through a cathepsin L (CTSL)-dependent mechanism.Conclusions IFN-gamma and mechanical stress contribute to melanocyte detachment from the basement membrane via CTSL, FAK and ITG beta 1 regulation. These findings highlight the importance of melanocyte-basement membrane adhesion in vitiligo pathogenesis and offer insight into the Koebner phenomenon in disease progression. Vitiligo is a persistent condition that affects the pigmentation (colour) of skin. Areas of skin become very pale or white. This is caused by the loss of skin cells called melanocytes. These cells produce a pigment called melanin. Melanin is responsible for skin, hair and eye colour.In vitiligo, melanocytes are mistakenly attacked by the body's own immune system. Melanocytes can be destroyed altogether or damaged, so that they no longer function correctly.We studied whether melanocyte damage is caused by a molecule called 'interferon gamma'. We combined this molecule with mechanical stress. Mechanical stress involved repeatedly stretching the skin cells in the lab. We found that the combination of interferon gamma and mechanical stress reduced the ability of melanocytes to work properly. The cells also produced fewer of the molecules they need to attach to skin ('attachment molecules'). When this was reversed, the melanocytes were able to attach properly.In conclusion, interferon gamma and mechanical stress may be important in vitiligo. This finding could help us develop new treatment strategies for vitiligo. Interferon-gamma and mechanical stress reduce focal adhesion between melanocytes and the basement membrane. This finding not only advances our understanding of vitiligo pathogenesis, but also highlights a novel therapeutic avenue and provides mechanistic insight into the Koebner phenomenon.

2026-04-01T00:00:00Z Qiao, Zhen Kim, Jin Yeong Zhang, Kelun Park, Chang Ook Shin, Yong https://ir.ymlib.yonsei.ac.kr/handle/22282913/211243 2026-03-16T04:50:06Z 2026-03-01T00:00:00Z

Title: Chia Seed Mucilage-Based Bilayer Sponges Containing Zinc Oxide Nanoparticles for Wound Dressing Authors: Qiao, Zhen; Kim, Jin Yeong; Zhang, Kelun; Park, Chang Ook; Shin, Yong Abstract: Effective wound management requires dressings that not only protect against infection but also support tissue regeneration. In this work, we present a chia seed mucilage/poly(vinyl alcohol) (CSMP)-zinc oxide (ZnO) bilayer wound dressing composed of a dense CSMP-ZnO hydrofilm as the outer protective barrier and a porous CSMP-ZnO sponge as the inner absorbent layer. The CSMP-ZnO bilayer wound dressing is fabricated via oven-drying and freeze-drying techniques, enabling a clear functional division between the outer protective layer and the inner wound-contacting layer and resulting in a stable and well-integrated structure. Mechanical testing demonstrates that the bilayer design synergistically combines the strength of the hydrofilm and the flexibility of the sponge, leading to improved mechanical integrity compared with single-layer structures, while the incorporation of ZnO nanoparticles enhances antibacterial performance. Water vapor permeability and contact angle analyses indicate that the dressing maintains a moist wound environment and exhibits tunable wettability, which are favorable for wound exudate management. In vitro evaluation using normal human dermal fibroblasts confirms good biocompatibility at low ZnO concentrations, and inhibition zone assays demonstrate effective antibacterial activity against both Gram-positive and Gram-negative bacteria. Furthermore, in vivo assessment using a murine scald wound model shows that the CSMP-ZnO bilayer wound dressing accelerates wound closure and promotes re-epithelialization compared with untreated wounds. Overall, this study highlights the CSMP-ZnO bilayer wound dressing as a multifunctional platform that integrates mechanical support, moisture regulation, antibacterial protection, and biocompatibility for advanced wound care applications.

2026-03-01T00:00:00Z