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mRNA-based allergen-specific immunotherapy to modulate type 2 airway inflammation

2026-04-29T08:26:58Z

Title: mRNA-based allergen-specific immunotherapy to modulate type 2 airway inflammation Authors: Zhang, KeLun; Park, Chang Ook

Trends in Contact Sensitization Among Korean Patients: A Multicenter 6-Year Retrospective Patch Test Study

2026-04-30T04:51:24Z

Title: Trends in Contact Sensitization Among Korean Patients: A Multicenter 6-Year Retrospective Patch Test Study Authors: Kim, Myoung Shin; Kim, Ho Sung; Park, Eun Joo; Kim, Hye One; Lee, Jungsoo; Lee, Dong Hun; Jung, Joon Min; Chang, Sung Eun; Jung, Hye Jung; Ko, Joo Yeon; Jue, Mihn-Sook; Choi, Sun Young; Jeon, Jiehyun; Kim, Myung Hwa; Cheong, Seung Hyun; Choi, Young-Jun; Lee, Sang Eun; Kim, Ki-Ho; Lee, Ga-Young Abstract: Background Allergic contact dermatitis is influenced by demographic factors. Updated epidemiologic data are needed to optimise patch test panels and preventive strategies.Objectives To evaluate trends and determinants of allergen sensitization in Korean patients undergoing patch testing.Methods Retrospective analysis of patch test records of 2271 patients at 15 university hospitals in Korea between 2019 and 2024. Patch test reactions were interpreted according to International Contact Dermatitis Research Group criteria. Association with age, sex, and body site was assessed.Results Overall, 57.1% of patients exhibited at least one positive reaction; among patients with positive reactions, 48.7% exhibited multi-sensitizations. Most frequent positive patch reactions were to nickel (29.0%), cobalt (18.2%), and chromium (8.2%). Women were more frequently sensitised to nickel and cobalt. Sensitization to fragrance mix I, Myroxylon pereirae resin, and p-phenylenediamine increased with age, whereas sensitization to thimerosal decreased. Facial involvement was associated with higher sensitization to lanolin alcohol; hand involvement with 2-mercaptobenzothiazole, colophonium, 4-tert-butylphenol formaldehyde resin and thimerosal; and scalp involvement with mercapto mix, 4-tert-butylphenol formaldehyde resin, p-phenylenediamine, and lanolin alcohol.Conclusions Metals, particularly nickel and cobalt, remain the predominant sensitizers in Korea. Age, sex, and localization differences underscore the need for targeted screening and public health strategies.

Chia Seed Mucilage-Based Bilayer Sponges Containing Zinc Oxide Nanoparticles for Wound Dressing

2026-03-16T04:50:06Z

Title: Chia Seed Mucilage-Based Bilayer Sponges Containing Zinc Oxide Nanoparticles for Wound Dressing Authors: Qiao, Zhen; Kim, Jin Yeong; Zhang, Kelun; Park, Chang Ook; Shin, Yong Abstract: Effective wound management requires dressings that not only protect against infection but also support tissue regeneration. In this work, we present a chia seed mucilage/poly(vinyl alcohol) (CSMP)-zinc oxide (ZnO) bilayer wound dressing composed of a dense CSMP-ZnO hydrofilm as the outer protective barrier and a porous CSMP-ZnO sponge as the inner absorbent layer. The CSMP-ZnO bilayer wound dressing is fabricated via oven-drying and freeze-drying techniques, enabling a clear functional division between the outer protective layer and the inner wound-contacting layer and resulting in a stable and well-integrated structure. Mechanical testing demonstrates that the bilayer design synergistically combines the strength of the hydrofilm and the flexibility of the sponge, leading to improved mechanical integrity compared with single-layer structures, while the incorporation of ZnO nanoparticles enhances antibacterial performance. Water vapor permeability and contact angle analyses indicate that the dressing maintains a moist wound environment and exhibits tunable wettability, which are favorable for wound exudate management. In vitro evaluation using normal human dermal fibroblasts confirms good biocompatibility at low ZnO concentrations, and inhibition zone assays demonstrate effective antibacterial activity against both Gram-positive and Gram-negative bacteria. Furthermore, in vivo assessment using a murine scald wound model shows that the CSMP-ZnO bilayer wound dressing accelerates wound closure and promotes re-epithelialization compared with untreated wounds. Overall, this study highlights the CSMP-ZnO bilayer wound dressing as a multifunctional platform that integrates mechanical support, moisture regulation, antibacterial protection, and biocompatibility for advanced wound care applications.

Clinical Efficacy of a Flavo-Proxylane Topical Regimen Pre- and Post-ultrasound Procedure for Subjects Undergoing Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist Therapy

2026-03-31T01:20:49Z

Title: Clinical Efficacy of a Flavo-Proxylane Topical Regimen Pre- and Post-ultrasound Procedure for Subjects Undergoing Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist Therapy Authors: Moradi, Amir; Kim, Jihee H.; Kim, Jemin M.; Choudhary, Hina N.; Brieva, Patricia M. Abstract: Introduction: Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are widely used for weight management and type 2 diabetes, but reports of reduced skin laxity and volume have raised aesthetic concerns. This study evaluates the first integrated skincare protocol designed for GLP-1 RA users. Methods: This 12-week, double-blind, randomized, split-face/split-neck study included 25 GLP-1 RA users (mean age 53.36 years) with mild-to-moderate skin aging, including male and female participants with Fitzpatrick skin types II to VI. All participants applied a topical regimen featuring Proxylane and wild fruit flavonoids (Flavo-Proxylane) to one side of the face/neck and a placebo to the other. After 4 weeks of topical monotherapy, participants received a single focused ultrasound treatment, followed by an additional 8 weeks of topical therapy. Outcomes included blinded image evaluation, 13 clinical grading parameters (via modified Griffiths scale), Global Aesthetic Improvement Scale scores, tolerability, and patient-reported satisfaction. Results: All participants completed the study and lost an average of 3.7 lb. After 4 weeks of Flavo-Proxylane monotherapy, significant improvements were observed for facial skin laxity (- 16%; P < 0.001) and marionette lines (- 5%; P < 0.05), while no significant changes were observed with placebo. By week 12, the combined regimen achieved amplified improvements versus baseline, week 4, and placebo (all P < 0.001), with total reductions of 44% in skin laxity and 34% in marionette lines. Significant improvements were observed across all 13 clinical parameters. Overall improvement rating favored Flavo-Proxylane, with 94% reporting moderate-to-significant improvement versus 30% for placebo. Flavo-Proxylane treatment was well tolerated, with 84% reporting improved skin appearance and only three mild, self-resolving adverse events. Conclusion: This study demonstrates that an integrated regimen with Flavo-Proxylane products and ultrasound may improve aesthetic outcomes in a diverse range of participants undergoing GLP-1 RA treatment.