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Eun Kyung Kim, Kyung A. Kim, Chang Young Lee, Hyo Sup Shim
The frequency and clinical impact of HER2 alterations in lung adenocarcinoma
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(IHC)Tj
1.9899 0 Td
(was)Tj
1.7008 0 Td
(performed)Tj
4.4673 0 Td
(using)Tj
2.3925 0 Td
(the)Tj
1.4683 0 Td
(ALK)Tj
2.1146 0 Td
(\(rabbit)Tj
2.948 0 Td
(mono-)Tj
-34.6504 -1.3039 Td
(clonal,)Tj
2.8516 0 Td
(clone)Tj
2.3641 0 Td
(D5F3,)Tj
2.6645 0 Td
(Cell)Tj
1.7972 0 Td
(Signaling)Tj
3.9401 0 Td
(Technology,)Tj
5.159 0 Td
(Danvers,)Tj
3.7757 0 Td
(MA,)Tj
2.0183 0 Td
(USA\))Tj
2.4605 0 Td
(and)Tj
1.7291 0 Td
(ROS1)Tj
2.5398 0 Td
(\(rabbit)Tj
2.9424 0 Td
(mono-)Tj
-34.2423 -1.2982 Td
(clonal,)Tj
2.8516 0 Td
(clone)Tj
2.3641 0 Td
(D4D6,)Tj
2.8743 0 Td
(Cell)Tj
1.7971 0 Td
(Signaling)Tj
3.9345 0 Td
(Technology,)Tj
5.1647 0 Td
(Danvers,)Tj
3.77 0 Td
(MA,)Tj
2.024 0 Td
(USA\))Tj
2.4548 0 Td
(antibodies.)Tj
4.5864 0 Td
(In)Tj
1.1112 0 Td
(IHC)Tj
-32.9327 -1.2983 Td
(positive)Tj
3.3165 0 Td
(cases,)Tj
2.4491 0 Td
(fluorescence)Tj
5.1817 0 Td
(in)Tj
1.0375 0 Td
(situ)Tj
1.6724 0 Td
(hybridization)Tj
5.6125 0 Td
(\(FISH\))Tj
3.0104 0 Td
(was)Tj
1.7008 0 Td
(performed)Tj
4.4674 0 Td
(using)Tj
2.3924 0 Td
(a)Tj
0.652 0 Td
(break-apart)Tj
-31.4927 -1.3039 Td
(ALK)Tj
2.1146 0 Td
(probe)Tj
2.5455 0 Td
(\(Vysis)Tj
2.6985 0 Td
(LSI)Tj
1.5761 0 Td
(Dual)Tj
2.16 0 Td
(Color,)Tj
2.7439 0 Td
(Break)Tj
2.5228 0 Td
(Apart)Tj
2.5285 0 Td
(Rearrangement)Tj
6.4006 0 Td
(Probe)Tj
2.5852 0 Td
(kit,)Tj
1.508 0 Td
(Abbott)Tj
3.0217 0 Td
(Molecular,)Tj
-32.4054 -1.2983 Td
(Abbott)Tj
3.0217 0 Td
(Park,)Tj
2.3074 0 Td
(IL,)Tj
1.3209 0 Td
(USA\))Tj
2.4548 0 Td
(or)Tj
1.0998 0 Td
(ROS1)Tj
2.5398 0 Td
(probe)Tj
2.5455 0 Td
(\(Abbott)Tj
3.3619 0 Td
(Molecular\).)Tj
/F12 1 Tf
4.8586 0 Td
[()]TJ
/F7 1 Tf
2.0409 0 Td
(or)Tj
/F12 1 Tf
1.0998 0 Td
[()8(\r)]TJ
/F7 1 Tf
2.4265 0 Td
(rearrangements)Tj
6.5139 0 Td
(were)Tj
-35.5915 -1.2982 Td
(scored)Tj
2.8346 0 Td
(as)Tj
1.0148 0 Td
(positive)Tj
3.3165 0 Td
(when)Tj
2.4038 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0239 0 Td
(15%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(tumor)Tj
2.7439 0 Td
(cells)Tj
1.9162 0 Td
(displayed)Tj
3.9798 0 Td
(split)Tj
1.9106 0 Td
(signals)Tj
2.9026 0 Td
(or)Tj
1.0999 0 Td
(isolated)Tj
3.2825 0 Td
(signals)Tj
-34.7185 -1.304 Td
(containing)Tj
4.524 0 Td
(a)Tj
0.6576 0 Td
(kinase)Tj
2.7496 0 Td
(domain)Tj
3.3222 0 Td
(\(red)Tj
1.8822 0 Td
(for)Tj
1.389 0 Td
(ALK)Tj
2.1146 0 Td
(and)Tj
1.7291 0 Td
(green)Tj
2.4548 0 Td
(for)Tj
1.3833 0 Td
(ROS1\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 562.0535 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Statistical)Tj
4.4504 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 545.0456 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(chi-square)Tj
4.4163 0 Td
(or)Tj
1.0942 0 Td
(Fisher's)Tj
3.2768 0 Td
(exact)Tj
2.2621 0 Td
(test)Tj
1.6044 0 Td
(was)Tj
1.6951 0 Td
(used)Tj
2.0636 0 Td
(to)Tj
1.0261 0 Td
(evaluate)Tj
3.4583 0 Td
(the)Tj
1.474 0 Td
(association)Tj
4.6261 0 Td
(between)Tj
3.5263 0 Td
(HER2)Tj
2.6532 0 Td
(status)Tj
-34.9566 -1.2982 Td
(and)Tj
1.7291 0 Td
(clinicopathological)Tj
7.7782 0 Td
(parameters.)Tj
4.8982 0 Td
(Correlations)Tj
5.2157 0 Td
(between)Tj
3.532 0 Td
(IHC)Tj
1.9899 0 Td
(and)Tj
1.7291 0 Td
(SISH)Tj
2.2791 0 Td
(were)Tj
2.1203 0 Td
(estimated)Tj
4.0762 0 Td
(using)Tj
-35.3478 -1.2983 Td
(Spearman's)Tj
4.8188 0 Td
(correlation)Tj
4.6148 0 Td
(coefficients)Tj
4.7395 0 Td
(\(kappa\);)Tj
3.5263 0 Td
(kappa)Tj
2.6192 0 Td
(values)Tj
/F14 1 Tf
0 Tc
2.6645 0 Td
(>)Tj
/F7 1 Tf
-0.004 Tc
(0.75)Tj
2.6476 0 Td
(denote)Tj
2.948 0 Td
(excellent)Tj
3.719 0 Td
(agreement,)Tj
-32.2977 -1.3039 Td
(values)Tj
2.6645 0 Td
(between)Tj
3.5319 0 Td
(0.4)Tj
1.3947 0 Td
(and)Tj
1.7291 0 Td
(0.75)Tj
1.8709 0 Td
(denote)Tj
2.9536 0 Td
(fairly)Tj
2.2791 0 Td
(good)Tj
2.228 0 Td
(agreement,)Tj
4.6488 0 Td
(and)Tj
1.7348 0 Td
(values)Tj
/F14 1 Tf
0 Tc
2.6645 0 Td
(<)Tj
/F7 1 Tf
-0.004 Tc
(0.4)Tj
2.1714 0 Td
(denote)Tj
2.948 0 Td
(poor)Tj
2.1203 0 Td
(agree-)Tj
-34.9396 -1.2983 Td
(ment.)Tj
2.5341 0 Td
(Overall)Tj
3.1408 0 Td
(survival)Tj
3.3392 0 Td
(\(OS\))Tj
2.1203 0 Td
(was)Tj
1.7007 0 Td
(assessed)Tj
3.4753 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(date)Tj
1.9048 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1918 0 Td
(to)Tj
1.0262 0 Td
(that)Tj
1.7801 0 Td
(of)Tj
1.0148 0 Td
(death)Tj
2.4321 0 Td
(or)Tj
1.0942 0 Td
(the)Tj
1.4683 0 Td
(last)Tj
-34.9112 -1.2982 Td
(follow-up)Tj
4.0932 0 Td
(visit.)Tj
2.0919 0 Td
(Disease-free)Tj
5.0853 0 Td
(survival)Tj
3.3336 0 Td
(\(DFS\))Tj
2.6418 0 Td
(was)Tj
1.7008 0 Td
(measured)Tj
4.1045 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(date)Tj
1.8992 0 Td
(of)Tj
1.0148 0 Td
(surgery)Tj
3.1974 0 Td
(to)Tj
1.0262 0 Td
(that)Tj
1.7801 0 Td
(of)Tj
-35.6482 -1.3039 Td
(cancer)Tj
2.8402 0 Td
(recurrence)Tj
4.5298 0 Td
(or)Tj
1.0998 0 Td
(the)Tj
1.4684 0 Td
(last)Tj
1.559 0 Td
(follow-up)Tj
4.0932 0 Td
(visit.)Tj
2.0976 0 Td
(Survival)Tj
3.4469 0 Td
(rates)Tj
2.109 0 Td
(were)Tj
2.126 0 Td
(calculated)Tj
4.2009 0 Td
(using)Tj
2.3924 0 Td
(the)Tj
1.4684 0 Td
(Kaplan)Tj
-33.4316 -1.2983 Td
(Meier)Tj
2.5965 0 Td
(method,)Tj
3.5489 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4741 0 Td
(differences)Tj
4.5637 0 Td
(were)Tj
2.1203 0 Td
(analyzed)Tj
3.702 0 Td
(using)Tj
2.3925 0 Td
(the)Tj
1.4683 0 Td
(log-rank)Tj
3.6397 0 Td
(test.)Tj
1.8255 0 Td
(Multivariate)Tj
5.1363 0 Td
(analysis)Tj
-34.1969 -1.2983 Td
(was)Tj
1.6951 0 Td
(performed)Tj
4.473 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.474 0 Td
(Cox)Tj
1.8538 0 Td
(proportional)Tj
5.3121 0 Td
(hazards)Tj
3.2882 0 Td
(model,)Tj
2.9707 0 Td
(which)Tj
2.6475 0 Td
(was)Tj
1.7008 0 Td
(expressed)Tj
4.0932 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(hazard)Tj
-34.5484 -1.3039 Td
(ratio)Tj
2.0976 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6519 0 Td
(95%)Tj
1.9332 0 Td
(confidence)Tj
4.5978 0 Td
(interval.)Tj
3.4923 0 Td
(P-values)Tj
/F14 1 Tf
0 Tc
3.5716 0 Td
(<)Tj
/F7 1 Tf
-0.004 Tc
(0.05)Tj
2.6475 0 Td
(were)Tj
2.1203 0 Td
(considered)Tj
4.6035 0 Td
(statistically)Tj
4.6091 0 Td
(significant.)Tj
-32.3204 -1.2983 Td
(Statistical)Tj
4.0195 0 Td
(analyses)Tj
3.4865 0 Td
(were)Tj
2.1203 0 Td
(performed)Tj
4.4731 0 Td
(using)Tj
2.3867 0 Td
(the)Tj
1.4684 0 Td
(IBM)Tj
2.0352 0 Td
(SPSS)Tj
2.2054 0 Td
(22)Tj
1.1679 0 Td
(software)Tj
3.5886 0 Td
(for)Tj
1.389 0 Td
(Windows)Tj
4.0818 0 Td
(\(IBM)Tj
2.3698 0 Td
(Corp,)Tj
-34.7922 -1.2982 Td
(New)Tj
2.0636 0 Td
(York,)Tj
2.4491 0 Td
(USA\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 366.0094 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F0 1 Tf
0 -1.4976 Td
(Patient)Tj
3.2976 0 Td
(characteristics)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 331.0299 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(According)Tj
4.439 0 Td
(to)Tj
1.0204 0 Td
(criteria)Tj
3.0784 0 Td
(described)Tj
4.0536 0 Td
(above,)Tj
2.7722 0 Td
(419)Tj
1.6441 0 Td
(patients)Tj
3.3676 0 Td
(were)Tj
2.1259 0 Td
(ultimately)Tj
4.235 0 Td
(selected)Tj
3.3448 0 Td
(for)Tj
1.389 0 Td
(analysis:)Tj
3.5489 0 Td
(321)Tj
-35.0189 -1.2982 Td
(had)Tj
1.7064 0 Td
(adenocarcinomas)Tj
7.251 0 Td
(and)Tj
1.7291 0 Td
(96)Tj
1.1735 0 Td
(had)Tj
1.7065 0 Td
(squamous)Tj
4.2689 0 Td
(cell)Tj
1.5591 0 Td
(carcinomas.)Tj
5.0343 0 Td
(Characteristics)Tj
6.1454 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3676 0 Td
(with)Tj
-34.9566 -1.3039 Td
(adenocarcinoma)Tj
6.8881 0 Td
(are)Tj
1.4513 0 Td
(summarized)Tj
5.1817 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(Table)Tj
2.4378 0 Td
(1)Tj
0 g
(.)Tj
0.9241 0 Td
(Lung)Tj
2.3017 0 Td
(adenocarcinoma)Tj
6.8881 0 Td
(samples)Tj
3.3789 0 Td
(were)Tj
2.126 0 Td
(derived)Tj
-32.6152 -1.2983 Td
(from)Tj
2.2053 0 Td
(163)Tj
1.6441 0 Td
(men)Tj
2.0126 0 Td
(and)Tj
1.7291 0 Td
(158)Tj
1.6497 0 Td
(women)Tj
3.2032 0 Td
(aged)Tj
2.0692 0 Td
(3390)Tj
2.6419 0 Td
(years)Tj
2.2621 0 Td
(\(mean)Tj
2.7892 0 Td
(=)Tj
0.7994 0 Td
(61.8)Tj
1.8708 0 Td
(years\).)Tj
2.829 0 Td
(This)Tj
1.9842 0 Td
(population)Tj
-29.6898 -1.2983 Td
(included)Tj
3.7133 0 Td
(196)Tj
1.6441 0 Td
(non-smokers)Tj
5.5162 0 Td
(\(61.6%\))Tj
3.3108 0 Td
(and)Tj
1.7292 0 Td
(125)Tj
1.644 0 Td
(former)Tj
3.0047 0 Td
(or)Tj
1.0942 0 Td
(current)Tj
3.1861 0 Td
(smokers)Tj
3.5603 0 Td
(\(38.9%\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 242.9858 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(HER2)Tj
2.8582 0 Td
(overexpression)Tj
6.9166 0 Td
(and)Tj
1.8662 0 Td
(its)Tj
1.2094 0 Td
(clinicopathological)Tj
8.2111 0 Td
(significance)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 225.9779 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Of)Tj
1.2529 0 Td
(321)Tj
1.6497 0 Td
(adenocarcinomas,)Tj
7.4721 0 Td
(membranous)Tj
5.5389 0 Td
(or)Tj
1.0998 0 Td
(cytoplasmic)Tj
4.9719 0 Td
(HER2)Tj
2.6532 0 Td
(expression)Tj
4.4674 0 Td
(was)Tj
1.6951 0 Td
(classified)Tj
3.8211 0 Td
(as)Tj
1.0148 0 Td
(neg-)Tj
-35.6369 -1.2982 Td
(ative)Tj
2.0976 0 Td
(in)Tj
1.0318 0 Td
(192)Tj
1.6497 0 Td
(cases)Tj
2.2224 0 Td
(\(59.8%\),)Tj
3.5376 0 Td
(low)Tj
1.6554 0 Td
(in)Tj
1.0375 0 Td
(98)Tj
1.1679 0 Td
(\(30.5%\),)Tj
3.5376 0 Td
(intermediate)Tj
5.3234 0 Td
(in)Tj
1.0318 0 Td
(25)Tj
1.1735 0 Td
(\(7.8%\),)Tj
3.0558 0 Td
(and)Tj
1.7348 0 Td
(high)Tj
2.0069 0 Td
(in)Tj
1.0318 0 Td
(6)Tj
0.6973 0 Td
(\(1.9%\))Tj
-33.9928 -1.2983 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(H-scoring)Tj
4.2859 0 Td
(method)Tj
3.3222 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8199 0 Td
(1)Tj
0 g
(\).)Tj
1.2585 0 Td
(Membranous)Tj
5.6126 0 Td
(expression)Tj
4.4674 0 Td
(of)Tj
1.0148 0 Td
(HER2)Tj
2.6532 0 Td
(was)Tj
1.7008 0 Td
(scored)Tj
2.8346 0 Td
(as)Tj
1.0148 0 Td
(0)Tj
0.6916 0 Td
(in)Tj
1.0375 0 Td
(248)Tj
-34.3613 -1.3039 Td
(samples)Tj
3.3788 0 Td
(\(77.3%\),)Tj
3.5376 0 Td
(1+)Tj
1.2756 0 Td
(in)Tj
1.0375 0 Td
(48)Tj
1.1679 0 Td
(\(15.0%\),)Tj
3.5376 0 Td
(2+)Tj
1.2756 0 Td
(in)Tj
1.0318 0 Td
(21)Tj
1.1735 0 Td
(\(6.5%\),)Tj
3.0614 0 Td
(and)Tj
1.7291 0 Td
(3+)Tj
1.2756 0 Td
(in)Tj
1.0318 0 Td
(4)Tj
0.6973 0 Td
(\(1.2%\))Tj
2.8347 0 Td
(according)Tj
4.1895 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
-33.2615 -1.2983 Td
(ASCO/CAP)Tj
5.0229 0 Td
(guidelines)Tj
4.2803 0 Td
(of)Tj
1.0148 0 Td
(breast)Tj
2.6135 0 Td
(cancer.)Tj
3.0728 0 Td
(Cytoplasmic)Tj
5.21 0 Td
(expression)Tj
4.4674 0 Td
(without)Tj
3.3278 0 Td
(membranous)Tj
5.5389 0 Td
(stain-)Tj
-34.5484 -1.2982 Td
(ing)Tj
1.5023 0 Td
(was)Tj
1.6951 0 Td
(observed)Tj
3.7984 0 Td
(in)Tj
1.0318 0 Td
(26)Tj
1.1736 0 Td
(adenocarcinomas)Tj
7.2509 0 Td
(\(8.1%\).)Tj
3.0558 0 Td
(Among)Tj
3.2484 0 Td
(them,)Tj
2.5115 0 Td
(only)Tj
1.9786 0 Td
(one)Tj
1.7008 0 Td
(case)Tj
1.8595 0 Td
(showed)Tj
3.2485 0 Td
(a)Tj
0.6576 0 Td
(high)Tj
-34.7128 -1.2983 Td
(H-score,)Tj
3.651 0 Td
(but)Tj
1.5477 0 Td
(did)Tj
1.5477 0 Td
(not)Tj
1.5703 0 Td
(exhibit)Tj
/F12 1 Tf
2.9764 0 Td
[( )]TJ
/F7 1 Tf
2.5625 0 Td
(amplification.)Tj
-12.6594 -1.3039 Td
(Clinicopathologic)Tj
7.1205 0 Td
(al)Tj
0.8958 0 Td
(findings)Tj
3.4979 0 Td
(observed)Tj
3.7928 0 Td
(in)Tj
1.0374 0 Td
(lung)Tj
2.0069 0 Td
(adenocarcinomas)Tj
7.251 0 Td
(with)Tj
1.9956 0 Td
(or)Tj
1.0998 0 Td
(without)Tj
3.3279 0 Td
(HER2)Tj
-33.2218 -1.2983 Td
(overexpression)Tj
6.2191 0 Td
(are)Tj
1.4514 0 Td
(summarized)Tj
5.1817 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0374 0 Td
(Table)Tj
2.4435 0 Td
(1)Tj
0 g
(.)Tj
0.9184 0 Td
(High)Tj
2.2507 0 Td
(expression)Tj
4.4617 0 Td
(of)Tj
1.0148 0 Td
(HER2)Tj
2.6532 0 Td
(\(H-score)Tj
/F6 1 Tf
0 Tc
3.7644 0 Td
()Tj
/F7 1 Tf
-0.004 Tc
(200\))Tj
2.7609 0 Td
(was)Tj
-34.1572 -1.2982 Td
(more)Tj
2.3414 0 Td
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218.5016 139.892 m
154.4579 139.892 l
154.4579 140.3921 l
218.0015 140.3921 l
f*
277.2989 152.392 m
277.2989 139.892 l
276.7989 140.3921 l
276.7989 152.392 l
f*
277.2989 139.892 m
218.5016 139.892 l
218.5016 140.3921 l
276.7989 140.3921 l
f*
341.3426 152.392 m
341.3426 139.892 l
340.8426 140.3921 l
340.8426 152.392 l
f*
341.3426 139.892 m
277.2989 139.892 l
277.2989 140.3921 l
340.8426 140.3921 l
f*
397.0789 152.392 m
397.0789 139.892 l
396.5788 140.3921 l
396.5788 152.392 l
f*
397.0789 139.892 m
341.3426 139.892 l
341.3426 140.3921 l
396.5788 140.3921 l
f*
456.7198 152.392 m
456.7198 139.892 l
456.2198 140.3921 l
456.2198 152.392 l
f*
456.7198 139.892 m
397.0789 139.892 l
397.0789 140.3921 l
456.2198 140.3921 l
f*
520.7635 152.392 m
520.7635 139.892 l
520.2635 140.3921 l
520.2635 152.392 l
f*
520.7635 139.892 m
456.7198 139.892 l
456.7198 140.3921 l
520.2635 140.3921 l
f*
575.9997 139.892 m
520.7635 139.892 l
520.7635 140.3921 l
575.9997 140.3921 l
f*
154.4579 139.892 m
154.4579 127.3921 l
153.9578 127.8921 l
153.9578 139.892 l
f*
154.4579 127.3921 m
36 127.3921 l
36 127.8921 l
153.9578 127.8921 l
f*
218.5016 139.892 m
218.5016 127.3921 l
218.0015 127.8921 l
218.0015 139.892 l
f*
218.5016 127.3921 m
154.4579 127.3921 l
154.4579 127.8921 l
218.0015 127.8921 l
f*
277.2989 139.892 m
277.2989 127.3921 l
276.7989 127.8921 l
276.7989 139.892 l
f*
277.2989 127.3921 m
218.5016 127.3921 l
218.5016 127.8921 l
276.7989 127.8921 l
f*
341.3426 139.892 m
341.3426 127.3921 l
340.8426 127.8921 l
340.8426 139.892 l
f*
341.3426 127.3921 m
277.2989 127.3921 l
277.2989 127.8921 l
340.8426 127.8921 l
f*
397.0789 139.892 m
397.0789 127.3921 l
396.5788 127.8921 l
396.5788 139.892 l
f*
397.0789 127.3921 m
341.3426 127.3921 l
341.3426 127.8921 l
396.5788 127.8921 l
f*
456.7198 139.892 m
456.7198 127.3921 l
456.2198 127.8921 l
456.2198 139.892 l
f*
456.7198 127.3921 m
397.0789 127.3921 l
397.0789 127.8921 l
456.2198 127.8921 l
f*
520.7635 139.892 m
520.7635 127.3921 l
520.2635 127.8921 l
520.2635 139.892 l
f*
520.7635 127.3921 m
456.7198 127.3921 l
456.7198 127.8921 l
520.2635 127.8921 l
f*
575.9997 127.3921 m
520.7635 127.3921 l
520.7635 127.8921 l
575.9997 127.8921 l
f*
154.4579 127.3921 m
154.4579 114.8922 l
153.9578 115.3922 l
153.9578 127.3921 l
f*
154.4579 114.8922 m
36 114.8922 l
36 115.3922 l
153.9578 115.3922 l
f*
218.5016 127.3921 m
218.5016 114.8922 l
218.0015 115.3922 l
218.0015 127.3921 l
f*
218.5016 114.8922 m
154.4579 114.8922 l
154.4579 115.3922 l
218.0015 115.3922 l
f*
277.2989 127.3921 m
277.2989 114.8922 l
276.7989 115.3922 l
276.7989 127.3921 l
f*
277.2989 114.8922 m
218.5016 114.8922 l
218.5016 115.3922 l
276.7989 115.3922 l
f*
341.3426 127.3921 m
341.3426 114.8922 l
340.8426 115.3922 l
340.8426 127.3921 l
f*
341.3426 114.8922 m
277.2989 114.8922 l
277.2989 115.3922 l
340.8426 115.3922 l
f*
397.0789 127.3921 m
397.0789 114.8922 l
396.5788 115.3922 l
396.5788 127.3921 l
f*
397.0789 114.8922 m
341.3426 114.8922 l
341.3426 115.3922 l
396.5788 115.3922 l
f*
456.7198 127.3921 m
456.7198 114.8922 l
456.2198 115.3922 l
456.2198 127.3921 l
f*
456.7198 114.8922 m
397.0789 114.8922 l
397.0789 115.3922 l
456.2198 115.3922 l
f*
520.7635 127.3921 m
520.7635 114.8922 l
520.2635 115.3922 l
520.2635 127.3921 l
f*
520.7635 114.8922 m
456.7198 114.8922 l
456.7198 115.3922 l
520.2635 115.3922 l
f*
575.9997 114.8922 m
520.7635 114.8922 l
520.7635 115.3922 l
575.9997 115.3922 l
f*
36 114.8922 m
575.9997 114.8922 l
575.9997 114.3921 l
36 114.3921 l
f*
0 g
1 j
1 J
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(Patient)Tj
3.5079 0 Td
(characte)Tj
4.0394 0 Td
(ristics)Tj
3.1182 0 Td
(accordi)Tj
3.5008 0 Td
(ng)Tj
1.4386 0 Td
(to)Tj
1.1551 0 Td
(HER2)Tj
2.8488 0 Td
(protein)Tj
3.5717 0 Td
(overexp)Tj
3.7701 0 Td
(ression)Tj
3.7276 0 Td
(and)Tj
1.9843 0 Td
(gene)Tj
2.5228 0 Td
(amplifica)Tj
4.2733 0 Td
(tion.)Tj
0 Tc
-43.5192 -1.8567 Td
(Characte)Tj
4.2449 0 Td
(ristics,)Tj
3.4441 0 Td
(n)Tj
0.8362 0 Td
(\(%\))Tj
9.0568 0 Td
(Total)Tj
10.5308 0 Td
(Protein)Tj
3.6638 0 Td
(overexpress)Tj
5.8465 0 Td
(ion)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 350.8724 697.4362 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(a)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 448.2708 693.8645 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(Gene)Tj
2.7212 0 Td
(amplica)Tj
4.3158 0 Td
(tion)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 521.1212 697.4362 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(b)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 232.3842 680.8818 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(Positiv)Tj
3.2669 0 Td
(e)Tj
4.2449 0 Td
(Negative)Tj
7.8379 0 Td
(P)Tj
0.9 0 Td
(value)Tj
6.1229 0 Td
(Positive)Tj
7.5685 0 Td
(Negative)Tj
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(P)Tj
0.8929 0 Td
(value)Tj
/F0 1 Tf
-46.5381 -1.6228 Td
(321)Tj
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(\(100\))Tj
6.4842 0 Td
(6)Tj
0.7796 0 Td
(\(1.9\))Tj
6.0732 0 Td
(315)Tj
1.878 0 Td
(\(98.1\))Tj
13.0962 0 Td
(46)Tj
1.3252 0 Td
(\(14.3\))Tj
6.1299 0 Td
(275)Tj
1.878 0 Td
(\(85.7\))Tj
-56.2043 -1.5662 Td
(Age)Tj
1.9985 0 Td
(\(years\))Tj
38.3813 0 Td
(0.424)Tj
22.4293 0 Td
(1.000)Tj
/F8 1 Tf
-61.8099 -1.559 Td
[( )]TJ
/F0 1 Tf
(62)Tj
15.5411 0 Td
(171)Tj
1.878 0 Td
(\(53.3\))Tj
6.3495 0 Td
(2)Tj
0.7796 0 Td
(\(33.3\))Tj
6.3496 0 Td
(169)Tj
1.878 0 Td
(\(53.7\))Tj
13.0962 0 Td
(25)Tj
1.3252 0 Td
(\(54.3\))Tj
6.1299 0 Td
(147)Tj
1.878 0 Td
(\(53.5\))Tj
/F6 1 Tf
-55.2051 -1.5662 Td
()Tj
/F0 1 Tf
(62)Tj
15.5411 0 Td
(150)Tj
1.878 0 Td
(\(46.7\))Tj
6.3495 0 Td
(4)Tj
0.7796 0 Td
(\(66.7\))Tj
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(146)Tj
1.878 0 Td
(\(46.3\))Tj
13.0962 0 Td
(21)Tj
1.3252 0 Td
(\(45.7\))Tj
6.1299 0 Td
(128)Tj
1.878 0 Td
(\(46.5\))Tj
-56.2043 -1.559 Td
(Gender)Tj
40.3798 0 Td
(1.000)Tj
22.4293 0 Td
(0.429)Tj
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(Male)Tj
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(163)Tj
1.878 0 Td
(\(50.8\))Tj
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(3)Tj
0.7796 0 Td
(\(50.0\))Tj
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(160)Tj
1.878 0 Td
(\(50.8\))Tj
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(26)Tj
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(\(56.5\))Tj
6.1299 0 Td
(137)Tj
1.878 0 Td
(\(49.8\))Tj
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(Female)Tj
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(158)Tj
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(\(49.2\))Tj
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(3)Tj
0.7796 0 Td
(\(50.0\))Tj
6.3496 0 Td
(155)Tj
1.878 0 Td
(\(49.2\))Tj
13.0962 0 Td
(20)Tj
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(\(43.5\))Tj
6.1299 0 Td
(138)Tj
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(\(50.2\))Tj
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(Smoking)Tj
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(status)Tj
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(0.681)Tj
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(0.746)Tj
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(Never)Tj
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(196)Tj
1.878 0 Td
(\(61.1\))Tj
6.3495 0 Td
(3)Tj
0.7796 0 Td
(\(50.0\))Tj
6.3496 0 Td
(193)Tj
1.878 0 Td
(\(61.3\))Tj
13.0962 0 Td
(27)Tj
1.3252 0 Td
(\(58.7\))Tj
6.1299 0 Td
(169)Tj
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(\(61.5\))Tj
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(Former)Tj
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(/current)Tj
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(125)Tj
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(\(38.9\))Tj
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(3)Tj
0.7796 0 Td
(\(50.0\))Tj
6.3496 0 Td
(122)Tj
1.878 0 Td
(\(38.7\))Tj
13.0962 0 Td
(19)Tj
1.3252 0 Td
(\(41.3\))Tj
6.1299 0 Td
(106)Tj
1.878 0 Td
(\(38.5\))Tj
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(Tumor)Tj
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(size)Tj
1.9984 0 Td
(\(cm\))Tj
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(0.697)Tj
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(0.628)Tj
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-61.8099 -1.5662 Td
()Tj
/F0 1 Tf
(3)Tj
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(187)Tj
1.878 0 Td
(\(58.3\))Tj
6.3495 0 Td
(3)Tj
0.7796 0 Td
(\(50.0\))Tj
6.3496 0 Td
(184)Tj
1.878 0 Td
(\(58.4\))Tj
13.0962 0 Td
(25)Tj
1.3252 0 Td
(\(54.3\))Tj
6.1299 0 Td
(163)Tj
1.878 0 Td
(\(59.3\))Tj
/F8 1 Tf
-55.2051 -1.559 Td
[( !)]TJ
/F0 1 Tf
(3)Tj
15.5411 0 Td
(134)Tj
1.878 0 Td
(\(41.7\))Tj
6.3495 0 Td
(3)Tj
0.7796 0 Td
(\(50.0\))Tj
6.3496 0 Td
(131)Tj
1.878 0 Td
(\(41.6\))Tj
13.0962 0 Td
(21)Tj
1.3252 0 Td
(\(45.7\))Tj
6.1299 0 Td
(112)Tj
1.878 0 Td
(\(40.7\))Tj
-56.2043 -1.5591 Td
(Nodal)Tj
2.8134 0 Td
(metastasis)Tj
37.5664 0 Td
(0.187)Tj
22.4293 0 Td
(0.242)Tj
-61.8099 -1.5661 Td
(Positive)Tj
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(111)Tj
1.878 0 Td
(\(34.6\))Tj
6.3495 0 Td
(4)Tj
0.7796 0 Td
(\(66.7\))Tj
6.3496 0 Td
(107)Tj
1.878 0 Td
(\(34.0\))Tj
13.0962 0 Td
(20)Tj
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(\(43.5\))Tj
6.3992 0 Td
(92)Tj
1.3323 0 Td
(\(33.5\))Tj
-54.9287 -1.5591 Td
(Negativ)Tj
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(e)Tj
12.182 0 Td
(210)Tj
1.878 0 Td
(\(65.4\))Tj
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(2)Tj
0.7796 0 Td
(\(33.3\))Tj
6.3496 0 Td
(208)Tj
1.878 0 Td
(\(66.0\))Tj
13.0962 0 Td
(26)Tj
1.3252 0 Td
(\(56.5\))Tj
6.1299 0 Td
(183)Tj
1.878 0 Td
(\(66.5\))Tj
-56.2043 -1.5662 Td
(Patholog)Tj
3.9119 0 Td
(ic)Tj
0.9496 0 Td
(stage)Tj
35.5183 0 Td
(0.104)Tj
22.4293 0 Td
(0.661)Tj
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(I)Tj
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(177)Tj
1.878 0 Td
(\(55.1\))Tj
6.3495 0 Td
(2)Tj
0.7796 0 Td
(\(33.3\))Tj
6.3496 0 Td
(175)Tj
1.878 0 Td
(\(55.6\))Tj
13.0962 0 Td
(25)Tj
1.3252 0 Td
(\(54.3\))Tj
6.1299 0 Td
(151)Tj
1.878 0 Td
(\(54.9\))Tj
-55.2051 -1.5662 Td
(II)Tj
15.8175 0 Td
(58)Tj
1.3323 0 Td
(\(18.1\))Tj
7.3062 0 Td
(0)Tj
0.7867 0 Td
(\(0\))Tj
5.9315 0 Td
(58)Tj
1.3252 0 Td
(\(18.4\))Tj
14.06 0 Td
(6)Tj
0.7795 0 Td
(\(13\))Tj
6.2575 0 Td
(52)Tj
1.3323 0 Td
(\(18.9\))Tj
-54.9287 -1.5591 Td
(III)Tj
15.8175 0 Td
(79)Tj
1.3323 0 Td
(\(24.6\))Tj
6.6188 0 Td
(4)Tj
0.7796 0 Td
(\(66.7\))Tj
6.626 0 Td
(75)Tj
1.3252 0 Td
(\(23.8\))Tj
13.3726 0 Td
(14)Tj
1.3252 0 Td
(\(30.4\))Tj
6.8173 0 Td
(66)Tj
1.3323 0 Td
(\(24\))Tj
-55.3468 -1.5661 Td
(IV)Tj
16.3632 0 Td
(7)Tj
0.7866 0 Td
(\(2.2\))Tj
7.3062 0 Td
(0)Tj
0.7867 0 Td
(\(0\))Tj
6.4772 0 Td
(7)Tj
0.7795 0 Td
(\(2.2\))Tj
13.9182 0 Td
(1)Tj
0.7796 0 Td
(\(2.2\))Tj
6.952 0 Td
(6)Tj
0.7795 0 Td
(\(2.2\))Tj
-55.9279 -1.5591 Td
(Histologic)Tj
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(subtype)Tj
35.8514 0 Td
(0.718)Tj
22.4293 0 Td
(0.082)Tj
-61.8099 -1.5661 Td
(Lepidic)Tj
16.0939 0 Td
(24)Tj
1.3252 0 Td
(\(7.5\))Tj
7.0369 0 Td
(0)Tj
0.7867 0 Td
(\(0\))Tj
6.2008 0 Td
(24)Tj
1.3323 0 Td
(\(7.6\))Tj
13.6418 0 Td
(2)Tj
0.7796 0 Td
(\(4.3\))Tj
7.0937 0 Td
(22)Tj
1.3323 0 Td
(\(8\))Tj
-55.6232 -1.5591 Td
(Acinar)Tj
15.9592 0 Td
(154)Tj
1.878 0 Td
(\(48\))Tj
5.9314 0 Td
(2)Tj
0.7796 0 Td
(\(33.3\))Tj
6.3496 0 Td
(152)Tj
1.878 0 Td
(\(48.3\))Tj
13.0962 0 Td
(27)Tj
1.3252 0 Td
(\(58.7\))Tj
6.1299 0 Td
(126)Tj
1.878 0 Td
(\(45.8\))Tj
-55.2051 -1.5662 Td
(Papillary)Tj
15.8175 0 Td
(41)Tj
1.3323 0 Td
(\(12.8\))Tj
6.6188 0 Td
(3)Tj
0.7796 0 Td
(\(50.0\))Tj
6.626 0 Td
(38)Tj
1.3252 0 Td
(\(12.1\))Tj
13.6419 0 Td
(7)Tj
0.7866 0 Td
(\(15.2\))Tj
6.6685 0 Td
(34)Tj
1.3323 0 Td
(\(12.4\))Tj
-54.9287 -1.559 Td
(Micropapi)Tj
4.2946 0 Td
(llary)Tj
11.7993 0 Td
(30)Tj
1.3252 0 Td
(\(9.3\))Tj
7.0369 0 Td
(0)Tj
0.7867 0 Td
(\(0\))Tj
6.2008 0 Td
(30)Tj
1.3323 0 Td
(\(9.5\))Tj
13.7836 0 Td
(6)Tj
0.7795 0 Td
(\(13\))Tj
6.5339 0 Td
(24)Tj
1.3323 0 Td
(\(8.7\))Tj
-55.2051 -1.5662 Td
(Solid)Tj
15.8175 0 Td
(57)Tj
1.3323 0 Td
(\(17.8\))Tj
7.3062 0 Td
(0)Tj
0.7867 0 Td
(\(0\))Tj
5.9315 0 Td
(57)Tj
1.3252 0 Td
(\(18.1\))Tj
13.9182 0 Td
(4)Tj
0.7796 0 Td
(\(8.7\))Tj
6.3992 0 Td
(54)Tj
1.3323 0 Td
(\(19.6\))Tj
-54.9287 -1.559 Td
(Mucinous)Tj
16.0939 0 Td
(15)Tj
1.3252 0 Td
(\(4.7\))Tj
6.3495 0 Td
(1)Tj
0.7796 0 Td
(\(16.7\))Tj
6.8953 0 Td
(14)Tj
1.3323 0 Td
(\(4.4\))Tj
14.0599 0 Td
(0)Tj
0.7796 0 Td
(\(0\))Tj
6.2575 0 Td
(15)Tj
1.3323 0 Td
(\(5.5\))Tj
-56.2043 -1.5662 Td
(Papillary)Tj
4.0323 0 Td
(predom)Tj
3.3591 0 Td
(inant)Tj
2.3811 0 Td
(type)Tj
/F2 1 Tf
30.6073 0 Td
(0.029)Tj
/F0 1 Tf
22.4293 0 Td
(0.633)Tj
-61.8099 -1.5591 Td
(Positive)Tj
15.8175 0 Td
(41)Tj
1.3323 0 Td
(\(12.8\))Tj
6.6188 0 Td
(3)Tj
0.7796 0 Td
(\(50.0\))Tj
6.626 0 Td
(38)Tj
1.3252 0 Td
(\(12.1\))Tj
13.6419 0 Td
(7)Tj
0.7866 0 Td
(\(15.2\))Tj
6.6685 0 Td
(34)Tj
1.3323 0 Td
(\(12.4\))Tj
-54.9287 -1.5661 Td
(Negativ)Tj
3.3591 0 Td
(e)Tj
12.182 0 Td
(280)Tj
1.878 0 Td
(\(87.2\))Tj
6.3495 0 Td
(3)Tj
0.7796 0 Td
(\(50.0\))Tj
6.3496 0 Td
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