Cited 18 times in
[18F]-Fluorodeoxyglucose Positron Emission Tomography Can Contribute to Discriminate Patients with Poor Prognosis in Hormone Receptor-Positive Breast Cancer.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한경화 | - |
dc.contributor.author | 손은주 | - |
dc.contributor.author | 안성귀 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 이민경 | - |
dc.contributor.author | 이학민 | - |
dc.contributor.author | 전태주 | - |
dc.contributor.author | 정준 | - |
dc.date.accessioned | 2015-01-06T17:09:51Z | - |
dc.date.available | 2015-01-06T17:09:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99454 | - |
dc.description.abstract | BACKGROUND: Patients with hormone receptor-positive breast cancer typically show favorable survival. However, identifying individuals at high risk of recurrence among these patients is a crucial issue. We tested the hypothesis that [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) scans can help predict prognosis in patients with hormone receptor-positive breast cancer. METHODS: Between April 2004 and December 2008, 305 patients with hormone receptor-positive breast cancer who underwent FGD-PET were enrolled. Patients with luminal B subtype were identified by positivity for human epidermal growth factor receptor-2 (HER2) or high Ki67 (≥14%) according to criteria recently recommended by the St. Gallen panelists. The cut-off value of SUVmax was defined using the time-dependent receiver operator characteristic curve for recurrence-free survival (RFS). RESULTS: At a median follow up of 6.23 years, continuous SUVmax was a significant prognostic factor with a hazard ratio (HR) of 1.21 (p = 0.021). The cut-off value of SUVmax was defined as 4. Patients with luminal B subtype (n = 82) or high SUVmax (n = 107) showed a reduced RFS (p = 0.031 and 0.002, respectively). In multivariate analysis for RFS, SUVmax carried independent prognostic significance (p = 0.012) whereas classification with immunohistochemical markers did not (p = 0.274). The Harell c-index was 0.729. High SUVmax was significantly associated with larger tumor size, positive nodes, HER2 positivity, high Ki67 (≥14%), high tumor grade, and luminal B subtype. CONCLUSIONS: Among patients with hormone receptor-positive breast cancer, FDG-PET can help discriminate patients at high risk of tumor relapse. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e105905 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Breast Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Breast Neoplasms/metabolism | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ki-67 Antigen/metabolism | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Radiopharmaceuticals* | - |
dc.subject.MESH | Receptor, ErbB-2/metabolism* | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Tomography, Emission-Computed, Single-Photon | - |
dc.title | [18F]-Fluorodeoxyglucose Positron Emission Tomography Can Contribute to Discriminate Patients with Poor Prognosis in Hormone Receptor-Positive Breast Cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Minkyung Lee | - |
dc.contributor.googleauthor | Tae Joo Jeon | - |
dc.contributor.googleauthor | Kyunghwa Han | - |
dc.contributor.googleauthor | Hak Min Lee | - |
dc.contributor.googleauthor | Seung Ah Lee | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Eun Ju Son | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.identifier.doi | 10.1371/journal.pone.0105905 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04267 | - |
dc.contributor.localId | A01988 | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A02780 | - |
dc.contributor.localId | A03272 | - |
dc.contributor.localId | A03727 | - |
dc.contributor.localId | A03557 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 25167062 | - |
dc.contributor.alternativeName | Han, Kyung Hwa | - |
dc.contributor.alternativeName | Son, Eun Ju | - |
dc.contributor.alternativeName | Ahn, Sung Gwe | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Lee, Min Kyung | - |
dc.contributor.alternativeName | Lee, Hak Min | - |
dc.contributor.alternativeName | Jeon, Tae Joo | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Han, Kyung Hwa | - |
dc.contributor.affiliatedAuthor | Son, Eun Ju | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Gwe | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Min Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Hak Min | - |
dc.contributor.affiliatedAuthor | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Jeon, Tae Joo | - |
dc.citation.volume | 9 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | e105905 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(8) : e105905, 2014 | - |
dc.identifier.rimsid | 39438 | - |
dc.type.rims | ART | - |
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