Cited 0 times in
Glutathione rescues brain endothelial cells from hydrogen peroxide-induced oxidative stress by activating Nrf2 expression.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박경아 | - |
dc.contributor.author | 송주현 | - |
dc.contributor.author | 이원택 | - |
dc.contributor.author | 이종은 | - |
dc.date.accessioned | 2015-01-06T16:35:59Z | - |
dc.date.available | 2015-01-06T16:35:59Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98407 | - |
dc.description.abstract | Glutathione (GSH) protects cells against oxidative stress by playing an antioxidant role. Protecting brain endothelial cells under oxidative stress is key to treating cerebrovascular diseases and neurodegenerative diseases including Alzheimer's disease and Huntington's disease. In present study, we investigated the protective effect of GSH on brain endothelial cells against hydrogen peroxide (H2O2). We showed that GSH attenuates H2O2-induced production of nitric oxide (NO), reactive oxygen species (ROS), and 8-Oxo-2'-deoxyguanosine (8-OHdG), an oxidized form of deoxiguanosine. GSH also prevents H2O2-induced reduction of tight junction proteins. Finally, GSH increases the level of nuclear factor erythroid 2-related factor 2 (Nrf2) and activates Nrf2-mediated signaling pathways. Thus, GSH is a promising target to protect brain endothelial cells in conditions of brain injury and disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 93~103 | - |
dc.relation.isPartOf | EXPERIMENTAL NEUROBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Glutathione rescues brain endothelial cells from hydrogen peroxide-induced oxidative stress by activating Nrf2 expression. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Juhyun Song | - |
dc.contributor.googleauthor | So Mang Kang | - |
dc.contributor.googleauthor | Won Taek Lee | - |
dc.contributor.googleauthor | Kyung Ah Park | - |
dc.contributor.googleauthor | Kyoung Min Lee | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.identifier.doi | 10.5607/en.2014.23.1.93 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01424 | - |
dc.contributor.localId | A02063 | - |
dc.contributor.localId | A03007 | - |
dc.contributor.localId | A03146 | - |
dc.relation.journalcode | J00872 | - |
dc.identifier.eissn | 2093-8144 | - |
dc.identifier.pmid | 24737944 | - |
dc.subject.keyword | Reactive oxygen species (ROS) | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | glutathione (GSH) | - |
dc.subject.keyword | hydrogen peroxide (H2O2) | - |
dc.subject.keyword | murine brain endothelial cells (bEnd.3 cells) | - |
dc.subject.keyword | nuclear factor erythroid 2-related factor 2 (Nrf2) | - |
dc.contributor.alternativeName | Park, Kyung Ah | - |
dc.contributor.alternativeName | Song, Ju Hyun | - |
dc.contributor.alternativeName | Lee, Won Taek | - |
dc.contributor.alternativeName | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Park, Kyung Ah | - |
dc.contributor.affiliatedAuthor | Song, Ju Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Won Taek | - |
dc.contributor.affiliatedAuthor | Lee, Jong Eun | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 93 | - |
dc.citation.endPage | 103 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL NEUROBIOLOGY, Vol.23(1) : 93-103, 2014 | - |
dc.identifier.rimsid | 56581 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.